Chronic Low Back Pain, bacterial infection and treatment with antibiotics

Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease

(2020) Shanmuganathan Rajasekaran et al.   EUROPEAN SPINE JOURNAL

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes)

(2020) Stefan Dudli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association Between Modic Changes and Low Back Pain in Middle Age

(2020) Jesperi Saukkonen et al.   SPINE

Waddell (Nonorganic) Signs and Their Association With Interventional Treatment Outcomes for Low Back Pain

(2020) Steven P. Cohen et al.   ANESTHESIA AND ANALGESIA

Are Modic type 2 disc changes associated with low-grade infections? A pilot study

(2020) Lorenzo Drago et al.   Journal of Neurosurgical Sciences

A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue

(2019) Manu N. Capoor et al.   EUROPEAN SPINE JOURNAL

Bacteria: back pain, leg pain and Modic sign—a surgical multicentre comparative study

(2019) Peter Fritzell et al.   EUROPEAN SPINE JOURNAL

Is the discopathy associated with Modic changes an infectious process? Results from a prospective monocenter study

(2019) Salim Ahmed-Yahia et al.   PLoS One

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial

(2019) Lars Christian Haugli Bråten et al.   BMJ-British Medical Journal

Bacterial biofilms: a possible mechanism for chronic infection in patients with lumbar disc herniation - a prospective proof-of-concept study using fluorescence in situ hybridization

(2018) Søren Ohrt-Nissen et al.   APMIS

Prevention and treatment of low back pain: evidence, challenges, and promising directions

(2018) Nadine E Foster et al.   LANCET

Trajectories and predictors of the long-term course of low back pain

(2018) Ying Chen et al.   PAIN

Global increase and geographic convergence in antibiotic consumption between 2000 and 2015

(2018) Eili Y. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of Propionic Acid in the Bovine Spinal Disk After Infection of the Tissue With Propionibacteria acnes Bacteria

(2018) Sergey Magnitsky et al.   SPINE

Latent infection of low-virulence anaerobic bacteria in degenerated lumbar intervertebral discs

(2018) Guoqing Tang et al.   BMC MUSCULOSKELETAL DISORDERS

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

(2018) Manu N. Capoor et al.   EUROPEAN SPINE JOURNAL

Cutibacterium acnes in Spine Pathology

(2018) Jad G. Khalil et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Ribosomal PCR assay of excised intervertebral discs from patients undergoing single-level primary lumbar microdiscectomy

(2017) Todd F. Alamin et al.   EUROPEAN SPINE JOURNAL

ISSLS PRIZE IN CLINICAL SCIENCE 2017: Is infection the possible initiator of disc disease? An insight from proteomic analysis

(2017) S. Rajasekaran et al.   EUROPEAN SPINE JOURNAL

Lack of effectiveness of antibiotics in chronic low back pain with Modic 1 changes

(2017) Clémence Palazzo et al.   JOINT BONE SPINE

Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy

(2017) Manu N. Capoor et al.   PLoS One

Long-term antibiotics for prevention of recurrent urinary tract infection in older adults: systematic review and meta-analysis of randomised trials

(2017) Haroon Ahmed et al.   BMJ Open

Histological Identification ofPropionibacterium acnesin Nonpyogenic Degenerated Intervertebral Discs

(2017) Ye Yuan et al.   Biomed Research International

Prospective study using anterior approach did not show association between Modic 1 changes and low grade infection in lumbar spine

(2016) Julien Rigal et al.   EUROPEAN SPINE JOURNAL

Letter to the Editor concerning “Prospective study using anterior approach did not show association between Modic 1 changes and low-grade infection in lumbar spine” by Rigal J, Thelen T, Byrne F, Cogniet A, Boissière L, Aunoble S, Le Huec JC (Eur Spine J [2016]; 25(4):1000–5. doi: 10.1007/s00586-016-4396-5)

(2016) Lloyd G. Czaplewski   EUROPEAN SPINE JOURNAL

Modic changes in the adjacent vertebrae due to disc material infection with Propionibacterium acnes in patients with lumbar disc herniation

(2016) Javad Aghazadeh et al.   EUROPEAN SPINE JOURNAL

Association Between Lumbar Disc Degeneration and Propionibacterium acnes Infection

(2016) Bo Li et al.   SPINE

Propionibacterium acnes, Coagulase-Negative Staphylococcus, and the “Biofilm-like” Intervertebral Disc

(2016) Michael F. Coscia et al.   SPINE

Prevalence of Propionibacterium acnes in Intervertebral Discs of Patients Undergoing Lumbar Microdiscectomy: A Prospective Cross-Sectional Study

(2016) Manu N. Capoor et al.   PLoS One

MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis

(2015) W. Brinjikji et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Association between changes in lumbar Modic changes and low back symptoms over a two-year period

(2015) Jyri Järvinen et al.   BMC MUSCULOSKELETAL DISORDERS

Back pain was less explained than leg pain: a cross-sectional study using magnetic resonance imaging in low back pain patients with and without radiculopathy

(2015) Ole Kudsk Jensen et al.   BMC MUSCULOSKELETAL DISORDERS

Relationship between annular tear and presence of Propionibacterium acnes in lumbar intervertebral disc

(2015) Zezhu Zhou et al.   EUROPEAN SPINE JOURNAL

Phenotype profiling of Modic changes of the lumbar spine and its association with other MRI phenotypes: a large-scale population-based study

(2015) Juhani H. Määttä et al.   Spine Journal

Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations

(2014) W. Brinjikji et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: a nested cohort study using magnetic resonance imaging of the lumbar spine

(2014) Ole Kudsk Jensen et al.   Spine Journal

Antimicrobial Susceptibility of Propionibacterium acnes Isolates from Shoulder Surgery

(2013) John K. Crane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevalence of the Fibromyalgia Phenotype in Patients With Spine Pain Presenting to a Tertiary Care Pain Clinic and the Potential Treatment Implications

(2013) Chad M. Brummett et al.   ARTHRITIS AND RHEUMATISM

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy

(2013) Hanne B. Albert et al.   EUROPEAN SPINE JOURNAL

Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?

(2013) Hanne B. Albert et al.   EUROPEAN SPINE JOURNAL

Genotypic and Antimicrobial Characterisation ofPropionibacterium acnesIsolates from Surgically Excised Lumbar Disc Herniations

(2013) Jess Rollason et al.   Biomed Research International

Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial

(2012) Rikke K Jensen et al.   BMC Medicine

Modic type I changes and recovery of back pain after lumbar microdiscectomy

(2012) Andreas Sørlie et al.   EUROPEAN SPINE JOURNAL

Bacteriology of Degenerated Lumbar Intervertebral Disks

(2012) Joseph Arndt et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Lumbar Modic Changes—A Comparison Between Findings at Low- and High-Field Magnetic Resonance Imaging

(2012) Tom Bendix et al.   SPINE

Clinical Results of Lumbar Total Disc Arthroplasty in Accordance With Modic Signs, With a 2-Year-Minimum Follow-up

(2011) Benjamin Blondel et al.   SPINE

Rating scales for low back pain

(2010) U. G. Longo et al.   BRITISH MEDICAL BULLETIN

What happens to Modic changes following lumbar discectomy? Analysis of a cohort of 41 patients with a 3- to 5-year follow-up period

(2010) Ralph Rahme et al.   JOURNAL OF NEUROSURGERY-SPINE

Bacteriologic Culture of Excised Intervertebral Disc From Immunocompetent Patients Undergoing Single Level Primary Lumbar Microdiscectomy

(2010) Vijay Agarwal et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Modic Changes on MR Images as Studied with Provocative Diskography: Clinical Relevance—A Retrospective Study of 2457 Disks

(2009) Kerry J. Thompson et al.   RADIOLOGY

Modic changes, possible causes and relation to low back pain

(2007) H.B. Albert et al.   MEDICAL HYPOTHESES