Article
Multidisciplinary Sciences
Nawraj Rummun, Ahmed Serag, Philippe Rondeau, Srishti Ramsaha, Emmanuel Bourdon, Theeshan Bahorun, Mohamed A. Farag, Vidushi S. Neergheen
Summary: The study revealed that the leaf extract of the endemic plant Syzygium coriaceum from Mauritius exhibits significant anticancer effects against hepatocellular carcinoma (HepG2) cells, possibly through multiple mechanisms including lactate dehydrogenase leakage, decrease in mitochondrial membrane potential, alterations in cell cycle distribution, and induction of apoptosis/necrosis. The metabolite profiling identified the presence of various compounds, with tannins and flavonoids being highlighted as potentially responsible for the antiproliferative effect against HepG2 cells.
Article
Entomology
Zhen-Jie Hu, Jing-Wei Yang, Zi-Han Chen, Cheng Chang, Yu-Pei Ma, Nan Li, Meng Deng, Gen-Lin Mao, Qiang Bao, Shu-Zhen Deng, Huan Liu
Summary: The study found that clove bud essential oil (CBEO) has a significant attractive effect on Bactrocera dorsalis males, but no attractancy to ladybirds and cytotoxicity to human and mouse cells. This research provides an eco-friendly and sustainable method for the control of B. dorsalis.
Article
Plant Sciences
Janice Mani, Joel Johnson, Holly Hosking, Beatriz E. Hoyos, Kerry B. Walsh, Paul Neilsen, Mani Naiker
Summary: This study selected five native Australian plants for screening, with Kakadu plum flesh extract showing the highest total phenolic content and antioxidant capacity. Extracts from Gumbi gumbi and Kakadu plum seeds exhibited significant cell inhibition in multiple cancer cell lines, indicating potential for further research.
Article
Pharmacology & Pharmacy
Abolfazl Shakeri, Seyedeh Sara Farahmand, Zahra Tayarani-Najaran, Seyed Ahmad Emami, Norbert Kusz, Judit Hohmann, Motahare Boozari, Fatemeh Zaker Tavallaie, Javad Asili
Summary: This study isolated the petroleum ether fraction from the roots of Salvia atropatana for the first time, showing growth inhibition and apoptosis induction in MCF-7 and PC3 cells. The most cytotoxic compound, a new abietane-type diterpenoid named atropatanene, exhibited significant cytotoxicity against PC3 cells. Bioassay-guided isolation methods were used to identify compounds with high cytotoxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Armania Nurdin, Latifah Saiful Yazan, Intan Safinar Ismail
Summary: This study aimed to isolate and elucidate the bioactive compounds responsible for the anticancer properties of Dillenia suffruticosa extract. Three triterpene compounds were successfully isolated, with one compound showing the highest cytotoxicity against cancer cells. These isolated compounds could be used for the standardization of herbal products from D. suffruticosa.
Article
Biochemistry & Molecular Biology
Marina Naldi, Gloria Brusotti, Gabriella Massolini, Vincenza Andrisano, Caterina Temporini, Manuela Bartolini
Summary: A combination of techniques was used to isolate phytochemicals with anticholinesterase activity from Phyllanthus muellarianus. Magnoflorine and nitidine were identified as active components from different subfractions and showed potent inhibitory effects on cholinesterases. Nitidine demonstrated comparable potency to the commercial anti-Alzheimer drug galanthamine and also showed weak antiaggregating activity against amyloid-beta self-aggregation.
Article
Food Science & Technology
Hongkun Xue, Jiaqi Tan, Xiaohan Zhu, Qian Li, Jintian Tang, Xu Cai
Summary: An effective method for selecting active compounds from cranberry was established using counter-current fractionation and bioassay-guided separation. The compound delphinidin-3-glucoside (D3G) showed the highest alpha-glucosidase inhibitory activity. D3G was found to interact with alpha-glucosidase through hydrophobic interactions, leading to changes in the enzyme's secondary structure, providing new insights into their interaction.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Manead Khin, Sonja L. Knowles, William J. Crandall, Derick D. Jones, Nicholas H. Oberlies, Nadja B. Cech, Joelle Houriet
Summary: Natural products have historically been a major source of medicines, with rosemary commonly used as a food preservative. This study identified strong inhibitory effects of micromeric acid and ursolic acid on MRSA from rosemary extracts.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Applied
Yuan He, Dongyu Lei, Qingqing Yang, Hao Qi, Kurax Almira, Dilnigar Askar, Lu Jin, Le Pan
Summary: Inspired by the allelopathetic effects of Xanthium orientale subsp. italicum, bioassay-guided isolation was used to identify its antitumor constituents and clarify the chemical basis of its multitarget activity. Among the compounds isolated, six active ones exhibited significant cytotoxicity against HepG two and A549 cells, providing a chemical basis for the genus Xanthium's multitarget and synergistic anticancer activity. The study's methodology could be useful for further research and development in cancer therapy using X. orientale.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juan Pablo Quintal Martinez, Irma Guadalupe Quintal Ortiz, Ligia Gabriela Alonso Salomon, Karlina Garcia-Sosa, Luis Manuel Pena Rodriguez, Jose Antonio Guerrero Analco, Juan Luis Monribot Villanueva, Abraham Marcelino Vidal Limon, Maira Rubi Segura Campos
Summary: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Previous studies have found that Cnidoscolus aconitifolius has antithrombotic properties. This study identified two antithrombotic compounds, Kaempferol-3-O-glucorhamnoside and 15(S)-HPETE, from C. aconitifolius. Further research is needed to understand their antithrombotic mechanism.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Agriculture, Dairy & Animal Science
Sugiyati Ningrum, Aji Sutrisno, Jue-Liang Hsu
Summary: An improved bioassay-guided fractionation method was used to screen ACE inhibitory peptides from milk protein hydrolysate. The study successfully identified a potent peptide, HL-7, which showed competitive inhibitory activity against ACE. The peptide could be extracted from commercially available milk powders using a simple solid-phase extraction process, making it a potential natural ACE inhibitor.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Marzieh Sadat Shojaee, Marzieh Moeenfard, Reza Farhoosh
Summary: This study determined the activity and capacity of gallic acid and methyl gallate in scavenging DPPH radical in different solvents. It was found that both antioxidants showed higher activity in alcoholic solvents, while methyl gallate had higher activity in polar aprotic solvents.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Azra Batool, Ghulam Abbas Miana, Mahboob Alam, Muhammad Tariq Khan, Muhammad Muddassir, Wajid Zaman, Saifullah Khan, Akhtar Aman, Ameer Khusro, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Muhammad Umar Khayam Sahibzada
Summary: The present research investigated the ethnopharmacological relevance of Saussurea species to anticancer compounds, leading to the isolation and characterization of three butyrolactone secondary metabolites. Arctigenin showed significant in vitro antiproliferative activity against HeLa cells and a promising docking against two HeLa proteins for the first time, highlighting its potential as a valuable drug for cervical cancer. Further research on the mechanism of action in vivo is suggested based on the cytotoxic activity and docking results.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Jerry O. Adeyemi, Gbemisola M. Saibu, Lukman O. Olasunkanmi, Adewale O. Fadaka, Mervin Meyer, Nicole R. S. Sibuyi, Damian C. Onwudiwe, Adebola O. Oyedeji
Summary: Two organic tin(IV) complexes with antioxidant and anti-inflammatory properties were synthesized and characterized, with butyltin(IV)-N-hydroxyethyl dithiocarbamate showing better cytotoxicity and antioxidant activity compared to methyltin(IV)-N-hydroxyethyl dithiocarbamate. The coordination of these complexes was through two sulfur atoms of the dithiocarbamate group, leading to a distorted octahedral geometry around the tin atom as shown by DFT calculation.
Article
Engineering, Multidisciplinary
Saeed M. M. Marji, Mohammad F. Bayan, Abdolelah Jaradat
Summary: This study highlights the simple synthesis of methyl gallate encapsulated folate-ZIF-L nanoframeworks (MG@Folate ZIF-L) and its potential applications in biomedical field. The nanoframeworks exhibited superior cytotoxic effect and anti-biofilm potential. With the unique physicochemical and biological characteristics, it overcomes the limitations of existing drug delivery systems and shows promising biomedical applications.
Article
Anesthesiology
Tian-Zhi Guo, Xiaoyou Shi, Wen-Wu Li, Tzuping Wei, Peyman Sahbaie, J. David Clark, Wade S. Kingery
Summary: In previous studies, B cells and autoantibodies were found to mediate chronic nociceptive sensitization in a mouse model of complex regional pain syndrome. The current study used a different model of low back pain to evaluate similar immune responses. The results showed that mice lacking mature B cells and antibodies had attenuated pain responses compared to wild-type mice. Increased expression of inflammatory cytokines, immune cell markers, and complement components were observed in the spinal cords of both groups. The study also found evidence of unique antibodies and targeted antigens generated in response to different types of tissue trauma. These findings further support the role of autoimmunity in the development of chronic musculoskeletal pain.
Article
Materials Science, Ceramics
Xiao Liu, Yafei Zhao, Yunyong Li, Wenwu Li
Summary: Silicon, as the highest capacity LIB anode material, has been commercialized. However, its slow conductivity impedes large-scale application. To improve the reaction kinetics, aluminum and phosphorus are co-introduced into silicon, forming a new family of AlSixP solid solutions. The AlSixP series materials show promising potential for utilization in LIBs due to their improved conductivity and stability.
CERAMICS INTERNATIONAL
(2023)
Review
Chemistry, Analytical
Judith B. Ngere, Kourosh H. Ebrahimi, Rachel Williams, Elisabete Pires, John Walsby-Tickle, James S. O. McCullagh
ANALYTICAL CHEMISTRY
(2023)
Article
Physics, Multidisciplinary
Fei Li, Zhijian He, Wenwu Li
Summary: We study the spatial structure of a Bose-Einstein condensate (BEC) with a space-dependent s-wave scattering length in a combined trap. The atomic current has an important influence on the spatial structure of the BEC. A large chemical potential can effectively suppress the chaotic spatial structure in the BEC system.
COMMUNICATIONS IN THEORETICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Jiangnan Xia, Xincan Qiu, Yu Liu, Ping-An Chen, Jing Guo, Huan Wei, Jiaqi Ding, Haihong Xie, Yawei Lv, Fuxiang Li, Wenwu Li, Lei Liao, Yuanyuan Hu
Summary: A general device fabrication strategy for metal halide perovskite (MHP) FETs is proposed, which successfully obtains transparent perovskite FETs. The strategy involves the use of ferroelectric copolymer poly(vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE) as the dielectric, which solves the challenging issue of gate-electric-field screening effect in MHP FETs. Additionally, ultra-thin SnO2 is inserted between the source/drain electrodes and MHPs to facilitate electron injection. These FETs have the attractiveness of low-cost, large-area transparent electronics applications.
Article
Chemistry, Multidisciplinary
Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield
Summary: Formaldehyde reacts with terminal proline-containing proteins to generate stable 5,5-bicyclic aminal termini that modulate protein function. This reaction has the potential to alter protein function and further investigations are required to understand the roles of histone modification. The findings suggest the potential regulatory roles of formaldehyde in protein function.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Nawraj Rummun, Bianca Payne, Analike Blom van Staden, Danielle Twilley, Brittany Houghton, Paul Horrocks, Wen-Wu Li, Namrita Lall, Theeshan Bahorun, Vidushi S. Neergheen
Summary: The tropical forests of the West Indian Ocean region contain unique plants with diverse chemical scaffolds that can be developed into medicinal agents. This study investigated the pharmacological potential of fourteen selected endemic species from the Mascarene Archipelago. Leaf extracts from species within the Ebeneceae, Myrtaceae, Sapotaceae, and Combretaceae families were evaluated for their polyphenolic content, antioxidant activity, anti-tyrosinase activity, antielastase activity, antiplasmodial activity, and toxicity. The results highlighted the potential of Terminalia bentzoe and Syzygium glomeratum as alternative sources of pharmaceutical compounds.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Yanhong Li, Lei Zhang, Jianbin Deng, Hung-Yu Yen, Songliu Yuan, Jeng-Han Wang, Chunfu Lin, Meilin Liu, Wenwu Li
Summary: By integrating GaP and Ge, a novel cation-disordered GaGeP2 compound is constructed via mechanical ball milling, which exhibits better lithium storage properties compared to GaP and Ge. The enhanced performance is attributed to the disordered lattice, resulting in faster reaction kinetics and stronger anti-volume pulverization capability. The cation-disordered GaGeP2 shows a highly reversible capacity of 1,410 mA h g-1 at 100 mA g-1, with an appropriate operating potential and high initial Coulombic efficiency. This study is of great significance to the field of energy storage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Energy & Fuels
Wenxia You, Daopeng Guo, Yonghua Wu, Wenwu Li
Summary: Accurate multivariate load forecasting is crucial for the planning management and safe operation of integrated energy systems. This paper proposes a hybrid ensemble learning method that combines sequential ensemble learning and parallel ensemble learning to simultaneously reduce prediction bias and variance. By using load correlation and the maximum information coefficient (MIC) for feature selection, the base learner utilizes Boost algorithm for sequential ensemble learning and Bagging algorithm for parallel ensemble learning in hybrid ensemble learning prediction. The grid search algorithm (GS) is employed for hyper-parameter optimization. Comparative analysis of example verification demonstrates that hybrid ensemble learning can better balance bias and variance and accurately predict multiple loads, such as electricity, cold, and heat, in integrated energy systems.
Article
Neurosciences
Azrul Abdul Kadir, Brianna J. Stubbs, Cher-Rin Chong, Henry Lee, Mark Cole, Carolyn Carr, David Hauton, James McCullagh, Rhys D. Evans, Kieran Clarke
Summary: Glucose and glycolysis play important roles in anaplerosis and beta HB oxidation in the heart. Glycogen, as a glucose store, can also contribute to anaplerosis. The study investigated the effects of glycogen content on beta HB oxidation and glycolytic rates in isolated rat hearts. Results showed that beta HB oxidation rates were lower in hearts with low glycogen content compared to high glycogen content, and beta HB oxidation inhibited glycolysis in all hearts. The findings suggest that glycogen facilitates cardiac beta HB oxidation and affects energetics.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Nanoscience & Nanotechnology
Yanhong Li, Lei Zhang, Hung-Yu Yen, Yucun Zhou, Gun Jang, Songliu Yuan, Jeng-Han Wang, Peixun Xiong, Meilin Liu, Ho Seok Park, Wenwu Li
Summary: This study successfully introduced liquid metallic Ga and highly reactive P into Si to create a cation-mixed disordered lattice and a unique Li storage mechanism. The resulting GaSiP2 electrodes showed high specific capacity and initial Coulombic efficiency, while the graphite-modified GaSiP2 achieved excellent capacity retention and high-rate capacity. The full cells using GaSiP2@C as anode material also exhibited high specific capacity after cycles, demonstrating the potential of GaSiP2 for high-performance LIBs.
NANO-MICRO LETTERS
(2023)
Article
Multidisciplinary Sciences
Annaelle Hip Kam, Wen -Wu Li, Theeshan Bahorun, Vidushi S. Neergheen
Summary: Epidemiological and clinical studies have shown that cooking methods can affect the nutritional composition and health benefits of vegetables and mushrooms. This study investigated the impact of boiling, steaming, and stir-frying on the phenolic content and antioxidant potential of locally grown vegetables and mushrooms. The results revealed that cooking methods can increase or decrease the phenolic content, but all cooked foods showed strong antioxidant properties. In addition, cooking enhanced the anti-proliferative effects of certain vegetables and mushrooms against liver cancer cells.
SCIENTIFIC AFRICAN
(2023)
Article
Physics, Multidisciplinary
Fei Li, Wenwu Li, Zhijian He
Summary: We studied the chaotic dynamics of the relative phase between two coupled Bose-Einstein condensates with small population imbalance. Using a two-mode approximation, we modeled the system as a Josephson junction with a ratchet potential. We derived a general solution for the symmetric case and analytically predicted the onset of chaos in the system using the Melnikov chaotic criterion. Numerical simulations showed that the relative phase can be constant in certain parameter spaces, indicating a simple or regular state. By adjusting the time-dependent nonlinear interaction or trap asymmetry parameters, we observed the transition from periodic to chaotic states.
ROMANIAN JOURNAL OF PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Vicki L. Emms, Liam A. Lewis, Lilla Beja, Natasha F. A. Bulman, Elisabete Pires, Frederick W. Muskett, James S. O. Mccullagh, Lonnie. P. Swift, Peter J. Mchugh, Richard J. Hopkinson
Summary: Research on formaldehyde is hindered by its reactivity and volatility. A new set of compounds have been developed as formaldehyde delivery agents, which have shown potential for cancer therapeutics.
Article
Plant Sciences
Anaswara Rani, Sneha Asha, Minsa Mini, Pooja P. Rajan, Merin Tomy, Ashita Jose, Xavier Ts, Praveen Kumar
Summary: This study focuses on the eco-friendly synthesis of copper oxide nanoparticles using Centra-therum punctatum leaf extract. The synthesized nanoparticles showed potent antimicrobial activity and effectively inhibited biofilm formation by Pseudomonas aeruginosa. These findings demonstrate the potential of copper oxide nanoparticles for environmentally friendly synthesis and applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)
Article
Plant Sciences
Bruno Fagundes dos Santos, Talita Oliveira de Arauja, Camilla Oliveira Rios, Advanio Inacio Siqueira-Silva, Eduardo Gusmao Pereira
Summary: This study investigated the interaction between iron excess and phosphorus deficiency in Paspalum densum. The results showed that iron excess decreased phosphorus concentration in roots, while phosphorus deficiency increased iron concentration in leaves. Stomatal limitation was the main cause of decreased photosynthesis due to iron excess. Phosphorus deficiency contributed to higher phosphorus use efficiency and biomass.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)
