Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 43, Issue 2, Pages 163-172Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-021-00844-1
Keywords
Spondyloarthritis; Microbial metabolite; SCFA; MCFA; SpA; Short chain fatty acid; Psoriatic arthritis; Polyamine; Trimethylamine; Tryptophan; Microbial trigger; Microbiota; Ankylosing spondylitis; Th17; Metabolite
Categories
Funding
- Judith and Stewart Colton Center for Autoimmunity
- NPF Psoriatic Arthritis Diagnostic Test Grant
- NIH [R01HL125816, R01AR070131, R01AR073851]
- Drs. Martin and Dorothy Spatz Foundation
- LEO Foundation [LF-OC-20-000351]
- Irma T. Hirschl and Monique Weill-Caulier Trust
- NIH/NIAMS [R01AR074500]
- Snyder Family Foundation
- Riley Family Foundation
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Spondyloarthritis is a chronic inflammatory disease affecting the bone, synovium, and enthesis, with gut dysbiosis being associated with altered microbial metabolites. Research has shown that changes in intestinal microbiota can modulate disease pathogenesis, with microbial metabolites and antigens playing a role in Spondyloarthritis.
Spondyloarthritis (SpA) is a group of chronic, immune-mediated, inflammatory diseases affecting the bone, synovium, and enthesis. Microbiome, the community of microorganisms that has co-evolved with human hosts, plays a pivotal role in human health and disease. This invisible essential organ supplies the host with a myriad of chemicals and molecules. In turn, microbial metabolites can serve as messengers for microbes to communicate with each other and in the cross-talk with host cells. Gut dysbiosis in SpA is associated with altered microbial metabolites, and an accumulated body of research has contributed to the understanding that changes in intestinal microbiota can modulate disease pathogenesis. We review the novel findings from human and animal studies to provide an overview of the contribution of individual microbial metabolites and antigens to SpA.
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