Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 42, Issue 3, Pages 635-650Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2020.11.008
Keywords
Dual triggering; GnRH agonist triggering; Human chorionic gonadotrophin; Luteal phase support; OHSS
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The study found that in high-risk women, the incidence of severe OHSS was 0% when no luteal support was provided, 1% with the addition of HCG to standard luteal support, and 1% with the use of a combination of GnRHa and HCG for triggering. However, the incidence of severe OHSS can be eliminated when no luteal support is provided.
The aim of the present systematic review and meta-analysis was to assess the incidence of severe ovarian hyperstimulation syndrome (OHSS) after triggering of final oocyte maturation with gonadotrophin releasing hormone agonist (GnRHa) in high-risk women. The pooled incidence of severe OHSS in high-risk women who did not receive any form of luteal phase support was 0% (95% CI 0.0 to 0.0, I-2 = 0%, random-effects model, 14 data sets, 983 women). The pooled incidence of severe OHSS in high-risk women in whom HCG was added to standard luteal phase support was 1% (95% CI 0.0 to 2.0, I-2 = 27.02%, random-effects model, 10 data sets, 707 women). The incidence of severe OHSS in high-risk women triggered by a combination of GnRHa and HCG (dual triggering), who received standard luteal phase support, was 1% (95% CI 0.0 to 3.0, one study, 182 women). The incidence of severe OHSS in high-risk women, is not eliminated when HCG is administered either concomitantly with GnRHa (dual triggering), during the luteal phase after GnRHa triggering, or both. On the contrary, it is eliminated when no luteal support is administered.
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