IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease

IDO Expression in Cancer: Different Compartment, Different Functionality?

(2020) Annabel Meireson et al.   Frontiers in Immunology

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer

(2019) Asha Jayakumar et al.   JOURNAL OF IMMUNOLOGY

Biochemical basis and metabolic interplay of redox regulation

(2019) Lixiao Zhang et al.   Redox Biology

Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity

(2019) Hao Shi et al.   Frontiers in Immunology

Matrix Metalloproteinase-9 in Monocytic Myeloid-Derived Suppressor Cells Correlate with Early Infections and Clinical Outcomes in Allogeneic Hematopoietic Stem Cell Transplantation

(2018) Sung-Eun Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

(2018) Bruce R. Blazar et al.   BLOOD

Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells

(2018) Ailin Li et al.   CANCER LETTERS

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation

(2017) Brent H. Koehn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of acute lethal pulmonary inflammation by the IDO–AhR pathway

(2017) Soung-Min Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease

(2017) Young-Kwan Lee et al.   Immune Network

Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?

(2016) Liang Wen et al.   Oncotarget

MyD88 in donor bone marrow cells is critical for protection from acute intestinal graft-vs.-host disease

(2015) J-Y Lim et al.   Mucosal Immunology

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A paradoxical pattern of indoleamine 2,3-dioxygenase expression in the colon tissues of patients with acute graft-versus-host disease

(2014) Gyeongsin Park et al.   EXPERIMENTAL HEMATOLOGY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways

(2014) Jeffrey A. Ericson et al.   PLoS One

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Indole peroxygenase activity of indoleamine 2,3-dioxygenase

(2012) H. H. Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis

(2010) M. A. Ciorba et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia

(2010) M Themeli et al.   LEUKEMIA

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

(2009) L. K. Jasperson et al.   BLOOD

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-κB and the generation of reactive oxygen species

(2009) Nanako Ogasawara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

A biomarker panel for acute graft-versus-host disease

(2008) S. Paczesny et al.   BLOOD

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Normal development and function of dendritic cells in mice lacking IDO-1 expression

(2008) Geoffroy de Faudeur et al.   IMMUNOLOGY LETTERS

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

(2007) L. K. Jasperson et al.   BLOOD