Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis

Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment

(2020) Tereza Filipi et al.   Journal of Clinical Medicine

Computational Investigation on Electrostatic Loop Mutants Instigating Destabilization and Aggregation on Human SOD1 Protein Causing Amyotrophic Lateral Sclerosis

(2019) E. Srinivasan et al.   PROTEIN JOURNAL

Virtual screening identification of novel chemical inhibitors for aberrant interactions between pathogenic mutant SOD1 and tubulin

(2019) Kazunori Hirayama et al.   NEUROCHEMISTRY INTERNATIONAL

In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine

(2019) Clara Carolina Silva De Oliveira et al.   PLoS One

In silico analysis of PFN1 related to amyotrophic lateral sclerosis

(2019) Gabriel Rodrigues Coutinho Pereira et al.   PLoS One

Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

(2019) Aline de Araújo Brasil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico cancer research towards 3R

(2018) Claire Jean-Quartier et al.   BMC CANCER

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease

(2018) Orietta Pansarasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling

(2018) Nikolay A. Alemasov et al.   BMC STRUCTURAL BIOLOGY

In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants

(2018) G. R. C. Pereira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Dynamics Simulation for All

(2018) Scott A. Hollingsworth et al.   NEURON

Aggregated SOD1 causes selective death of cultured human motor neurons

(2018) Chen Benkler et al.   Scientific Reports

Simulation Based Investigation of Deleterious nsSNPs in ATXN2 Gene and Its Structural Consequence Toward Spinocerebellar Ataxia

(2017) Siddharth Sinha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Parsing disease-relevant protein modifications from epiphenomena: perspective on the structural basis of SOD1-mediated ALS

(2017) N. D. Schmitt et al.   JOURNAL OF MASS SPECTROMETRY

A theoretical study on Zn binding loop mutants instigating destabilization and metal binding loss in human SOD1 protein

(2017) E. Srinivasan et al.   JOURNAL OF MOLECULAR MODELING

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

A profound computational study to prioritize the disease-causing mutations in PRPS1 gene

(2017) Ashish Kumar Agrahari et al.   METABOLIC BRAIN DISEASE

ClinVar: improving access to variant interpretations and supporting evidence

(2017) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells

(2017) Edward Pokrishevsky et al.   PLoS One

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

Current updates on computer aided protein modeling and designing

(2016) Faez Iqbal Khan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Large-scale screening in sporadic amyotrophic lateral sclerosis identifies genetic modifiers in C9orf72 repeat carriers

(2016) Annelot M. Dekker et al.   NEUROBIOLOGY OF AGING

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase

(2016)   NUCLEIC ACIDS RESEARCH

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040

(2016) Karissa C. Arthur et al.   Nature Communications

In silico toxicology: computational methods for the prediction of chemical toxicity

(2016) Arwa B. Raies et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

(2016) Luke McAlary et al.   Frontiers in Neuroscience

Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS

(2016) Junghee Lee et al.   Experimental Neurobiology

PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels

(2015) Yongwook Choi et al.   BIOINFORMATICS

Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21

(2015) Víctor Rodríguez-Sureda et al.   Oxidative Medicine and Cellular Longevity

Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic

(2015) Renzo Mancuso et al.   PROGRESS IN NEUROBIOLOGY

Structural investigation on the electrostatic loop of native and mutated SOD1 and their interaction with therapeutic compounds

(2015) S. P. Keerthana et al.   RSC Advances

Automatic Identification of Mobile and Rigid Substructures in Molecular Dynamics Simulations and Fractional Structural Fluctuation Analysis

(2015) Leandro Martínez   PLoS One

PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations

(2014) Jaroslav Bendl et al.   PLoS Computational Biology

Economic burden of amyotrophic lateral sclerosis: A Canadian study of out-of-pocket expenses

(2014) Matthew Gladman et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Mechanical Probes of SOD1 Predict Systematic Trends in Metal and Dimer Affinity of ALS-Associated Mutants

(2013) Atanu Das et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Functional Analysis of Human SOD1 in Amyotrophic Lateral Sclerosis

(2013) Lorenna Giannini Alves Moreira et al.   PLoS One

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

(2013) M. I. Ivanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

(2013) Melissa S. Rotunno et al.   Frontiers in Cellular Neuroscience

Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS

(2012) Matthis Synofzik et al.   HUMAN MOLECULAR GENETICS

ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics

(2012) Olubunmi Abel et al.   HUMAN MUTATION

The fundamental role of flexibility on the strength of molecular binding

(2012) Christopher Forrey et al.   Soft Matter

Is an Intuitive Convergence Definition of Molecular Dynamics Simulations Solely Based on the Root Mean Square Deviation Possible?

(2011) B. Knapp et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Determination of Ensemble-Average Pairwise Root Mean-Square Deviation from Experimental B-Factors

(2010) Antonija Kuzmanic et al.   BIOPHYSICAL JOURNAL

SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations

(2010) S. Millecamps et al.   JOURNAL OF MEDICAL GENETICS

Exposure of Hydrophobic Surfaces Initiates Aggregation of Diverse ALS-Causing Superoxide Dismutase-1 Mutants

(2010) Christian Münch et al.   JOURNAL OF MOLECULAR BIOLOGY

Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

(2010) J. R. Auclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q†

(2009) Duane D. Winkler et al.   BIOCHEMISTRY

Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods

(2009) Janita Thusberg et al.   HUMAN MUTATION

A Common Property of Amyotrophic Lateral Sclerosis-associated Variants

(2009) Kathleen S. Molnar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Human Extracellular Copper–Zinc Superoxide Dismutase at 1.7 Å Resolution: Insights into Heparin and Collagen Binding

(2009) Svetlana V. Antonyuk et al.   JOURNAL OF MOLECULAR BIOLOGY

Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation

(2009) P. Andreas Jonsson et al.   NEUROBIOLOGY OF DISEASE

Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase

(2009) Zeynep A. Oztug Durer et al.   PLoS One

Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases

(2009) Virginia Castillo et al.   PLoS Computational Biology

SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization

(2008) Lucia Banci et al.   PLoS One