Article
Oncology
Thomas Tessonnier, Stewart Mein, Dietrich W. M. Walsh, Nora Schuhmacher, Hans Liew, Rainer Cee, Michael Galonska, Stefan Scheloske, Christian Schomers, Uli Weber, Stephan Brons, Jurgen Debus, Thomas Haberer, Amir Abdollahi, Andrea Mairani, Ivana Dokic
Summary: The study aimed to investigate the effects of dose, LET, and O-2 concentration on biologic response to ultrahigh dose rate helium ion beams. Results showed no significant differences in cellular response between ultrahigh dose rate and standard dose rate irradiation at different doses and oxygen levels, but a FLASH sparing effect was observed under specific conditions.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Engineering, Biomedical
Yuting Lin, Bowen Lin, Shujun Fu, Michael M. Folkerts, Eric Abel, Jeffery Bradley, Hao Gao
Summary: This study develops a simultaneous dose and dose rate optimization (SDDRO) method with the joint use of high-energy transmission beams (TB) and Bragg peaks (BP), namely SDDRO-Joint. The addition of BP substantially increased the target dose conformality for SDDRO and provided slightly higher conformal index values than the conventional intensity modulated proton therapy (IMPT) method with BP alone. By combining TB and BP, the SDDRO-Joint method can achieve better sparing of organs-at-risk and other normal tissues.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth M. Fletcher, Facundo Ballester, Luc Beaulieu, Hali Morrison, Audran Poher, Mark J. Rivard, Ron S. Sloboda, Javier Vijande, Rowan M. Thomson
Summary: A joint working group was created to aid in the transition from the AAPM TG-43 dose calculation to model-based dose calculations. The group established test cases for low-energy photon-emitting brachytherapy using model-based algorithms. The data from these test cases can support the commissioning of MBDCAs for low-energy brachytherapy and serve as a framework for the development of test cases in other applications.
Article
Engineering, Civil
Di Weng, Ran Chen, Jianhui Zhang, Jie Bao, Yu Zheng, Yingcai Wu
Summary: Planning ideal transit routes in complex urban environments can enhance the performance of public transportation systems, but is challenging due to the huge number of possible routes. This study introduces the definition of pareto-optimal transit routes based on multiple criteria and develops an efficient search framework to address route extraction challenges.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2021)
Article
Engineering, Biomedical
Hoyeon Lee, Jungwook Shin, Joost M. Verburg, Mislav Bobic, Brian Winey, Jan Schuemann, Harald Paganetti
Summary: The objective of this study is to develop an open-source GPU-based MC package capable of scoring quantities that require a large amount of memory. A hash-table data structure is employed to efficiently utilize the limited GPU memory and score the quantities requiring extensive memory.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arash Darafsheh, Yao Hao, Xiandong Zhao, Townsend Zwart, Miles Wagner, Tucker Evans, Francisco Reynoso, Tianyu Zhao
Summary: This study demonstrated the feasibility of delivering protons in an SOBP pattern with >100 Gy/s average dose rate using a clinical synchrocyclotron. Dose heterogeneity can be improved through optimization of the range modulator and number of delivered spots. Plane-parallel chambers with smaller gap between electrodes are more suitable for FLASH dosimetry compared to other ion chambers used in this work.
Article
Engineering, Biomedical
Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch, Niayesh Afshordi, Radhe Mohan
Summary: This study presents a microscopic mechanism that explains the outward burst of 'cold' ion species in high-energy particle tracks. The interaction between 'hot' non-ion species and 'cold' ion species is mediated by acoustic phonons, allowing the conversion of thermal energy to kinetic energy. The results of simulations and analysis demonstrate the transport and diffusion of thermal energy in the track structures.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Brita Singers Sorensen, Mateusz Krzysztof Sitarz, Christina Ankjaergaard, Jacob G. Johansen, Claus E. Andersen, Eleni Kanouta, Cai Grau, Per Poulsen
Summary: This study investigated the effects of proton FLASH irradiation on tumor control and normal tissue toxicity in a mouse model. The results showed that proton FLASH had similar tumor control compared to conventional treatment, but reduced acute skin damage and radiation-induced fibrosis.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Chao Wu, Dan Nguyen, Yixun Xing, Ana Barragan Montero, Jan Schuemann, Haijiao Shang, Yuehu Pu, Steve Jiang
Summary: The study developed a deep learning model to convert PB dose to MC dose for improved accuracy in dose calculation. Training the model on data from all tumor sites and using the dose distribution of each individual beam as input yielded the best performance. The average gamma passing rates between the converted and MC dose were found to be 92.8%, 92.7%, 89.7%, and 99.6% for head and neck, liver, lung, and prostate test patients, respectively.
MACHINE LEARNING-SCIENCE AND TECHNOLOGY
(2021)
Article
Astronomy & Astrophysics
I Friscic, D. Nguyen, J. R. Pybus, A. Jentsch, E. P. Segarra, M. D. Baker, O. Hen, D. W. Higinbotham, R. Milner, A. S. Tadepalli, Z. Tu, J. Rittenhouse West
Summary: The study investigates the feasibility of suppressing model dependencies by tagging both spectator protons in the process of Deep Inelastic Scattering (DIS) off neutrons in He-3 at the forthcoming Electron-Ion Collider (EIC). It is demonstrated that the EIC can probe the neutron spin structure effectively, providing valuable insight into the spin and flavor structure of nucleons. The double spectator tagging method significantly reduces uncertainties in the extracted neutron spin asymmetries, especially in the low-x(B) region.
Article
Engineering, Biomedical
Yeon Soo Yeom, Keith T. Griffin, Matthew M. Mille, Choonik Lee, Shannon O'Reilly, Lei Dong, Jae Won Jung, Choonsik Lee
Summary: In this study, the fetal dose resulting from proton pencil beam scanning (PBS) craniospinal irradiation (CSI) during pregnancy was comprehensively investigated using Monte Carlo simulations. The majority of fetal organ/tissue doses fell within the range of 3-6 mGy, with the fetal whole-body dose ranging from 3.7 mGy to 5.8 mGy.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pavitra Ramesh, Wenbo Gu, Dan Ruan, Ke Sheng
Summary: This study incorporates dose rate objectives into the beam orientation optimization framework, and the results show that the dose rate techniques can significantly increase dose rate without compromising physical dose.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Shan, Hongying Feng, Danairis Hernandez Morales, Samir H. Patel, William W. Wong, Mirek Fatyga, Martin Bues, Steven E. Schild, Robert L. Foote, Wei Liu
Summary: The study proposed a novel concept of virtual particle MC simulation for accelerated proton therapy dose calculation on GPUs, achieving high efficiency and accuracy by ignoring certain particles and optimizing the calculation model. The method was validated in patient geometries and showed promising results in terms of dose calculation accuracy and efficiency.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sylvain Deffet, Valentin Hamaide, Edmond Sterpin
Summary: This study analyzes five different definitions of dose rate in FLASH proton therapy and finds that the choice of definition can significantly impact the calculated dose rate values. Careful consideration of the dose rate definition is essential for accurate and effective FLASH proton therapy.
Article
Chemistry, Physical
Z. A. Alrowaili, Jamila S. Alzahrani, Halil Arslan, Nada S. Alruwaili, Chalermpon Mutuwong, M. S. Al-Buriahi
Summary: Information on energy deposition in human tissues and organs is crucial for proton radiation treatment planning. This study investigated the Bragg curves, dose distributions, and target fragmentations of proton therapy using a newly developed thyroid phantom. The results showed that energy deposition rates increase (decrease) as proton energy increases at deeper (shallower) sides, with no energy deposition observed at around 30 MeV. In addition, the contribution of target fragmentation before the Bragg peak was quantified through the study of production cross sections and fluence of fragments.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Engineering, Biomedical
Behzad Rezaeifar, Cecile J. A. Wolfs, Natasja G. Lieuwes, Rianne Biemans, Brigitte Reniers, Ludwig J. Dubois, Frank Verhaegen
Summary: This study introduces a framework for using a deep convolutional neural network to predict the center of mass of glioblastoma tumors based on bioluminescence imaging. The predicted center of mass is then used to estimate a planning target volume, and the results show sub-millimeter accuracy for the prediction. The proposed method also demonstrates promising performance for tumor targeting while minimizing radiation exposure to healthy tissues.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Teun van Wagenberg, Gabriel Paiva Fonseca, Robert Voncken, Celine van Beveren, Evert van Limbergen, Ludy Lutgens, Ben G. L. Vanneste, Maaike Berbee, Brigitte Reniers, Frank Verhaegen
Summary: In this study, a heterogeneous head phantom was used to test an imaging panel (IP) approach for treatment verification and error detection. The results showed that the IP could accurately measure dwell times and positions, and detect simulated treatment errors.
Review
Engineering, Biomedical
Frank Verhaegen, Karl T. Butterworth, Anthony J. Chalmers, Rob P. Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D. Fenwick, Patrick Granton, Stefan H. J. Heijmans, Mark A. Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C. G. G. Persoon, Nick Staut, Anna Subiel, Rianne D. W. Vaes, Stefan van Hoof, Ioannis L. Verginadis, Jan J. Wilkens, Kaye J. Williams, George D. Wilson, Ludwig J. Dubois
Summary: This paper provides an overview of precision preclinical x-ray radiation studies in animal models. It focuses on cancer and normal tissue response to radiation, but also addresses other disease models. The advancements in imaging, irradiation, dosimetry, and monitoring are discussed, along with future developments. The paper also explores clinical translation and reverse translation.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ineke M. J. Pruijn, Jerome J. Waterval, Mark ter Laan, Yasin Temel, Sjoert A. H. Pegge, Alida A. Postma, Jeroen B. Verheul, Danielle B. P. Eekers, Wietske Kievit, Henricus P. M. Kunst
Summary: The study evaluated the validity of the Koos 2 subclassification and the inter- and intra-rater reliability of the entire Koos classification. The results showed high reliability for Koos 2a and 2b subclassification, which can aid in recommending treatment initiation and improving patient centered care.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
L. K. P. Regli, S. M. H. Huijs, R. C. O. S. Pasmans, C. Leue, J. B. Dijkstra, D. B. P. Eekers, K. E. Hovinga, M. H. M. E. Anten, A. Hoeben, M. P. G. Broen
Summary: This study aims to explore the incidence of clinically relevant psychiatric symptoms during glioblastoma treatment. It found that 11.5% of patients experienced psychiatric symptoms, with mood and behavioral symptoms being the most common. The study concludes that further research is needed to understand the potential impact of these symptoms on survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Max E. E. Keizer, Koos E. E. Hovinga, Martin Lacko, Danielle B. P. Eekers, Laura W. J. Baijens, Bernd Kremer, Yasin Temel
Summary: A retrospective study was conducted on 18 patients with malignant tumors of the sinonasal cavities extending to the frontal skull base in a hospital in the Netherlands. The study found that combined-approach surgery with adjuvant radiotherapy is a treatment strategy, and the overall survival rate was only 50%. Surgical complications were common, with radiation necrosis being a serious complication.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2023)
Article
Oncology
Ana Vaniqui, Femke Vaassen, Dario Di Perri, Danielle Eekers, Inge Compter, Ilaria Rinaldi, Wouter van Elmpt, Mirko Unipan
Summary: The study investigated the dose, dose-averaged linear energy transfer (LETd), and the product between dose and LETd (DLETd) distribution in a cohort of patients treated with proton therapy. Different treatment planning system features and visualization tools were explored. The findings highlight the importance of identifying and quantifying LET distributions in standardizing treatment planning and making informed decisions for clinicians.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Engineering, Biomedical
Behzad Rezaeifar, Cecile J. A. Wolfs, Natasja G. Lieuwes, Rianne Biemans, Brigitte Reniers, Ludwig J. Dubois, Frank Verhaegen
Summary: In this study, a novel solution is proposed for accurate 3D bioluminescence tomography (BLT) based glioblastoma (GBM) targeting. The solution utilizes a deep-learning approach to enable BLT-based tumor targeting and treatment planning for orthotopic rat GBM models. The results show that the deep learning model achieves high accuracy in tumor localization and treatment planning.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Esther Kneepkens, Cecile Wolfs, Roel-Germ Wanders, Erik Traneus, Danielle Eekers, Frank Verhaegen
Summary: The study tested the effects of shoot-through FLASH proton beams on dose-averaged LET (LETD) values and proton range in critical organs, and found that shoot-through plans have lower LETD values and better stability.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Petros Kalendralis, Samuel M. H. Luk, Richard Canters, Denis Eyssen, Ana Vaniqui, Cecile Wolfs, Lars Murrer, Wouter van Elmpt, Alan M. Kalet, Andre Dekker, Johan van Soest, Rianne Fijten, Catharina M. L. Zegers, Inigo Bermejo
Summary: This article presents a multi-institutional study on a Bayesian network-based tool for initial plan review in radiation oncology. The study found that training the model in institutions with similar technology and treatment protocols leads to better performance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Lieke In 't Ven, Inge Compter, Kyra van Eijsden, Jaap Zindler, Ans Swinnen, Dirk de Ruysscher, Tom Rozema, Esther G. C. Troost, Danielle B. P. Eekers
Summary: The purpose of this study was to develop a method to predict radiation-induced alopecia in brain tumor patients before the start of radiotherapy. A pilot study was conducted and the dose calculations were correlated with visible alopecia to create a predictive structure. The results showed that the method accurately predicted the extent of alopecia in the majority of patients.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)