Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform

(2019) Karin Hultman et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

(2019) Bhavani S. Sahu et al.   Cell Reports

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Clearance kinetics of the VGF-derived neuropeptide TLQP-21

(2018) ZengKui Guo et al.   NEUROPEPTIDES

Study of the Tissue Distribution of TLQP-21 in Mice Using [18F]JMV5763, a Radiolabeled Analog Prepared via [18F]Aluminum Fluoride Chelation Chemistry

(2018) Elia A. Turolla et al.   Frontiers in Pharmacology

Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons

(2017) Shao-Rui Chen et al.   JOURNAL OF NEUROCHEMISTRY

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

(2017) Cheryl Cero et al.   Molecular Metabolism

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research

(2016) Daniel J. Drucker   Cell Metabolism

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

(2016) Kaare V. Grunddal et al.   ENDOCRINOLOGY

Analytic framework for peptidomics applied to large-scale neuropeptide identification

(2016) Anna Secher et al.   Nature Communications

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Developmental Changes in Synaptic Distribution in Arcuate Nucleus Neurons

(2015) A. F. Baquero et al.   JOURNAL OF NEUROSCIENCE

Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells

(2015) Maja S. Engelstoft et al.   MOLECULAR ENDOCRINOLOGY

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

(2015) Louise S. Dalbøge et al.   PEPTIDES

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

(2015) Louise S. Dalbøge et al.   PLoS One

Neuroendocrine Role for VGF

(2015) Jo E. Lewis et al.   Frontiers in Endocrinology

The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure

(2014) Samira Fargali et al.   FASEB JOURNAL

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

(2014) Louise S. Dalbøge et al.   JOURNAL OF PEPTIDE SCIENCE

A role for VGF in the hypothalamic arcuate and paraventricular nuclei in the control of energy homeostasis

(2014) N. Saderi et al.   NEUROSCIENCE

The TLQP-21 Peptide Activates the G-Protein-Coupled Receptor C3aR1 via a Folding-upon-Binding Mechanism

(2014) Cheryl Cero et al.   STRUCTURE

Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala

(2013) J A Parker et al.   INTERNATIONAL JOURNAL OF OBESITY

Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells

(2013) Sebastien Hannedouche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function

(2012) Samuel B. Stephens et al.   Cell Metabolism

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21

(2011) Roberta Possenti et al.   BIOCHEMICAL JOURNAL

Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feeding

(2010) Carla Brancia et al.   JOURNAL OF ENDOCRINOLOGY

Leptin Excites Proopiomelanocortin Neurons via Activation of TRPC Channels

(2010) J. Qiu et al.   JOURNAL OF NEUROSCIENCE

A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides

(2010) Kazuki Sasaki et al.   JOURNAL OF PROTEOME RESEARCH

In vitroandin vivopharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat gastric motor functions

(2009) C Severini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice

(2009) Alessandro Bartolomucci et al.   Genes and Nutrition

Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance

(2009) N M Semjonous et al.   INTERNATIONAL JOURNAL OF OBESITY

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

(2008) K. Li et al.   BLOOD

The Neurotrophin-Inducible Gene Vgf Regulates Hippocampal Function and Behavior through a Brain-Derived Neurotrophic Factor-Dependent Mechanism

(2008) O. Bozdagi et al.   JOURNAL OF NEUROSCIENCE