Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6635836
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Funding
- National Natural Science Foundation of China [31900534]
- Natural Science Foundation of Hebei Province [C2019201349]
- Advanced Talents Incubation Program of Hebei University [801260201282]
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This review discusses how common and novel posttranslational modifications influence the development of cardiovascular diseases by regulating mitochondrial quality control. It provides insights for future research on the mechanisms of certain types of CVDs and potential therapeutic strategies for CVDs.
Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential.
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