Article
Genetics & Heredity
Juan Benito-Lozano, Blanca Lopez-Villalba, Greta Arias-Merino, Manuel Posada de la Paz, Veronica Alonso-Ferreira
Summary: According to data from the Spanish Rare Diseases Patient Registry, over half of the patients with rare diseases experience diagnostic delay, with an average time to diagnosis of 6.18 years. The study found a significant reduction in the percentage of patients with diagnostic delay and the average time to diagnosis over the study period. Female patients, those aged 30-44, and patients with mental and behavioral disorders or rare diseases of the nervous system were more likely to experience diagnostic delay.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Giuseppe Limongelli, Stefano Iucolano, Emanuele Monda, Pasquale Elefante, Chiara De Stasio, Imma Lubrano, Martina Caiazza, Marialuisa Mazzella, Fabio Fimiani, Maria Galdo, Giulia De Marchi, Martina Esposito, Marta Rubino, Annapaola Cirillo, Adelaide Fusco, Augusto Esposito, Ugo Trama, Salvatore Esposito, Gioacchino Scarano, Joseph Sepe, Generoso Andria, Valentina Orlando, Enrica Menditto, Paolo Chiodini
Summary: This study investigates the capacity of the rare disease healthcare network in Campania to diagnose patients with rare diseases during the Covid-19 outbreak, and sheds light on problematic diagnoses during this period. The results show that the prevalence of new diagnoses of rare disease was significantly lower during the outbreak, and various issues such as lack of diagnostic resources and guidelines were identified.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Ophthalmology
Esmee H. Runhart, Patty Dhooge, Magda Meester-Smoor, Jeroen Pas, Jan Willem R. Pott, Redmer van Leeuwen, Hester Y. Kroes, Arthur A. Bergen, Yvonne De Jong-Hesse, Alberta A. Thiadens, Mary J. van Schooneveld, Maria van Genderen, Camiel Boon, Caroline Klaver, L. Ingeborg van den Born, Frans P. M. Cremers, Carel B. Hoyng
Summary: This study aimed to assess the incidence of Stargardt disease and demographics of incident cases. The observed prevalence of STGD1 was lower than expected based on population ABCA4 allele frequencies, and late-onset STGD1 was more frequently diagnosed in recent years due to higher awareness of its phenotype. Misdiagnosis and underdiagnosis of late-onset STGD1, as well as the role of sex in STGD1, should receive special attention in the pretherapeutic era.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biology
Kris McGlinn, Matthew A. Rutherford, Karl Gisslander, Lucy Hederman, Mark A. Little, Declan O'Sullivan
Summary: This study addresses the fragmented and non-sharing nature of rare disease data by integrating data at a semantic level and proposing a federated querying approach. The paper demonstrates the successful application of these technologies to provide access and analysis of rare disease data while ensuring patient privacy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Genetics & Heredity
Nathalie M. Vandevelde, Pieter Vermeersch, Katrien M. J. Devreese, Marie-Francoise Vincent, Beatrice Gulbis, Francois Eyskens, Francois Boemer, Andre Gothot, Viviane O. Van Hoof, Carolien Bonroy, Hedwig Stepman, Geert A. Martens, Xavier Bossuyt, Laurence Roosens, Julie Smet, Hilde Laeremans, Ilse Weets, Jean-Marc Minon, Kris Vernelen, Wim Coucke
Summary: A feasibility study was conducted from May 2015 to August 2016 to select financeable biochemical analyses for rare diseases and determine which should be conducted by reference laboratories. This initiative led to the publication of new reimbursement conditions for 46 analyses and recognition of eighteen reference laboratories in 2019, as well as collaborations with foreign laboratories for outsourcing and financing analyses unavailable in Belgium.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Genetics & Heredity
Jian Guo, Peng Liu, Limeng Chen, Haohan Lv, Jie Li, Weichao Yu, Kaifeng Xu, Yicheng Zhu, Zhihong Wu, Zhuang Tian, Ye Jin, Rachel Yang, Weihong Gu, Shuyang Zhang
Summary: The preliminary analysis of the first 5-year's data provides unique and valuable insight on rare disease distribution in China, and highlights the directions for enhancing equity, scale and utility.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Multidisciplinary Sciences
Supot Kamsa-ard, Chalongpon Santong, Siriporn Kamsa-ard, Vor Luvira, Varisara Luvira, Krittika Suwanrungruang, Vajarabhongsa Bhudhisawasdi
Summary: This study used multiple statistical methods to analyze the incidence and survival rate trends of cholangiocarcinoma in northeastern Thailand. The results showed a decrease in the incidence rate of cholangiocarcinoma, with a projected continued decline in the future, though the survival rate of patients remains poor.
Review
Pharmacology & Pharmacy
Ryuichi Sakate, Tomonori Kimura
Summary: Drug repositioning is an effective approach for developing drugs for rare and intractable diseases. Preparation of ontology is crucial for drug development in these diseases, as disease names are inconsistently used worldwide. Ontology-based analysis of clinical trial data has revealed the active occurrence of drug repositioning in rare and intractable diseases, with drugs and their target genes playing a key role in exploring repositionable drugs.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, General & Internal
Nina Vibeche Skei, Tom Ivar Lund Nilsen, Siri Tandberg Knoop, Hallie Prescott, Stian Lydersen, Randi Marie Mohus, Alen Brkic, Kristin Vardheim Liyanarachi, Erik Solligard, Jan Kristian Damas, Lise Tuset Gustad
Summary: This study analyzed the temporal trends in incidence rate and case fatality from 2008 to 2021 and assessed the possible shifts in these trends during the COVID-19 pandemic. The study found that the incidence rate of first sepsis remained stable, but the incidence rate of recurrent sepsis increased. During the COVID-19 pandemic, the incidence rate of both first sepsis and all sepsis cases decreased. The case fatality of first sepsis decreased from 2009 to 2019 but increased during the COVID-19 pandemic.
Review
Medicine, General & Internal
Marinos Pericleous, Claire Kelly, Michael Schilsky, Anil Dhawan, Aftab Ala
Summary: This study aims to design a universal registry for rare liver diseases (RLDs) by utilizing lessons learned from established European registries. The study identified 37 registries for RLDs in Europe. The findings provide a toolkit for the design of RLD registries.
Article
Dermatology
Johan Kappelin, Adele C. Green, Asa Ingvar, Ingela Ahnlide, Kari Nielsen
Summary: The incidence rates of basal cell carcinoma in Sweden are relatively high and increasing, with more pronounced trends in women and aggressive BCC subtypes. The highest incidence was in elderly individuals, with the head and neck being the most common tumor site.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Min-Ying Chiang, Shih-Chieh Shao, Shu-Chen Liao
Summary: The study evaluated the accuracy of case definitions for COP using ICD-9-CM and ICD-10-CM diagnosis codes in Taiwan's health insurance claims data, finding that COP patients were not accurately identified with ICD-CM codes alone, but accuracy improved when including oxygen therapy data with the codes in the claims data.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiahong Shi, Nan Zhou, Biyu He, Xin Hong, Wei Guo, Lishan Jiang, Chenchen Wang, Lang Lei, Houxuan Li
Summary: This study evaluated the accuracy of the Ramfjord teeth (RT) protocol for diagnosing severe periodontitis based on different classifications and explored the bias of misclassification such as teeth loss. The results showed that RT had the highest specificity based on the new AAP/EFP classification. The loss of the first molar had the greatest impact on the detection rate of severe periodontitis.
Article
Gastroenterology & Hepatology
Laura Izquierdo-Sanchez, Angela Lamarca, Adelaida La Casta, Stefan Buettner, Kirsten Utpatel, Heinz-Josef Klumpen, Jorge Adeva, Arndt Vogel, Ana Lleo, Luca Fabris, Mariano Ponz-Sarvise, Raffaele Brustia, Vincenzo Cardinale, Chiara Braconi, Gianpaolo Vidili, Nigel B. Jamieson, Rocio Ir Macias, Jan Philipp Jonas, Marco Marzioni, Waclaw Holowko, Trine Folseraas, Juozas Kupcinskas, Zeno Sparchez, Marcin Krawczyk, Lukasz Krupa, Viorel Scripcariu, Gian Luca Grazi, Ana Landa-Magdalena, Jan Nm Ijzermans, Katja Evert, Joris Erdmann, Flora Lopez-Lopez, Anna Saborowski, Alexander Scheiter, Alvaro Santos-Laso, Guido Carpino, Jesper B. Andersen, Jose Jg Marin, Domenico Alvaro, Luis Bujanda, Alejandro Forner, Juan W. Valle, Bas Groot Koerkamp, Jesus M. Banales
Summary: This study investigates the clinical course of cholangiocarcinoma in a pan-European cohort and finds that the disease is frequently diagnosed at an advanced stage and a proportion of patients fail to receive cancer-specific therapies, resulting in a poor prognosis.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pediatrics
Yi Dong, Jian Wang, Shishu Zhu, Huanwei Zheng, Chunya Wang, Pan Zhao
Summary: Diagnosis of rare pediatric liver diseases is challenging due to lack of expert knowledge. A study analyzed 1158 pediatric patients with liver-involved rare diseases, identifying liver-based genetic diseases as the most frequent. Gene sequencing helped improve diagnostic quality for these disorders.
PEDIATRIC RESEARCH
(2021)
Article
Neurosciences
Oliver Ibarrondo, Jose Maria Huerta, Pilar Amiano, Maria Encarnacion Andreu-Reinon, Olatz Mokoroa, Eva Ardanaz, Rosa Larumbe, Sandra M. Colorado-Yohar, Fernando Navarro-Mateu, Maria Dolores Chirlaque, Javier Mar
Summary: This study developed and validated competing risk models to predict the late risk of dementia based on variables assessed in middle age in a southern European population. The study found that the AUC of the model for over-55-year-olds was much higher than the overall AUC in the first 15 years of follow-up and remained that way in the subsequent follow-up. The weight of the competing risk of death was greater than that of dementia, especially when the entire population was included.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Marcela Konjevod, Jorge Saiz, Coral Barbas, Alberto Bergareche, Eva Ardanaz, Jose Ma Huerta, Ana Vinagre-Aragon, Ma Elena Erro, Ma Dolores Chirlaque, Eunate Abilleira, Jesus Ma Ibarluzea, Pilar Amiano
Summary: The study utilized plasma samples from the EPIC-Navarra cohort, consisting of 12 PD patients and 21 control subjects. Through liquid chromatography coupled to tandem mass spectrometry, seven significantly different metabolites (benzoic acid, palmitic acid, oleic acid, stearic acid, myo-inositol, sorbitol, and quinolinic acid) were identified between PD cases and healthy controls. These metabolites are associated with mitochondrial dysfunction, oxidative stress, and energy production mechanisms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pediatrics
Naomi Ssenyonga, Charles Stiller, Kayo Nakata, Jaime Shalkow, Sheilagh Redmond, Jean-Luc Bulliard, Fabio Girardi, Christine Fowler, Raphael Marcos-Gragera, Audrey Bonaventure, Nathalie Saint-Jacques, Pamela Minicozzi, Prithwish De, Miguel Rodriguez-Barranco, Siri Laronningen, Veronica Di Carlo, Margit Magi, Mikhail Valkov, Karri Seppa, Dyfed Wyn Huws, Michel P. Coleman, Claudia Allemani
Summary: The study examines global survival trends in leukemia among young patients aged 0-24 years, revealing significant variations in survival rates across different countries and regions. Children consistently have higher survival rates compared to adolescents and young adults.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Oncology
Niki Dimou, Wemimo Omiyale, Carine Biessy, Vivian Viallon, Rudolf Kaaks, Tracy A. O'Mara, Elom K. Aglago, Eva Ardanaz, Manuela M. Bergmann, Nicola P. Bondonno, Tonje Braaten, Sandra M. Colorado-Yohar, Marta Crous-Bou, Christina C. Dahm, Renee T. Fortner, Inger T. Gram, Sophia Harlid, Alicia K. Heath, Annika Idahl, Marina Kvaskoff, Therese H. Nost, Kim Overvad, Domenico Palli, Aurora Perez-Cornago, Carlotta Sacerdote, Maria-Jose Sanchez, Matthias B. Schulze, Gianluca Severi, Vittorio Simeon, Giovanna Tagliabue, Anne Tjonneland, Therese Truong, Rosario Tumino, Mattias Johansson, Elisabete Weiderpass, Neil Murphy, Marc J. Gunter, Ben Lacey, Naomi E. Allen, Laure Dossus
Summary: This study investigates the association between smoking and endometrial cancer risk through observational and Mendelian randomization analyses. The observational analysis finds an inverse association between smoking and endometrial cancer risk, but this is not supported by the Mendelian randomization analysis. Further research is needed to understand the potential confounders and mechanisms underlying the observed associations between smoking and endometrial cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Nutrition & Dietetics
Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci de Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sanchez, Jose Maria Huerta, Anne Tjonneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts, Augustin Scalbert
Summary: Circulating levels of acylcarnitines (ACs) are influenced by various factors such as age, sex, diet, and fasting status. Different types of ACs are associated with corresponding fatty acids in plasma, specific food intake, and concentrations of branched-chain amino acids. Understanding the determinants of ACs can help interpret their associations with disease risk and provide insights into potential dietary and lifestyle factors for disease prevention.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Raul Zamora-Ros, Valerie Cayssials, Ramon Cleries, Maria Torrents, Graham Byrnes, Elisabete Weiderpass, Maria Sandstrom, Martin Almquist, Marie-Christine Boutron-Ruault, Anne Tjonneland, Cecilie Kyro, Verena A. Katzke, Charlotte Le Cornet, Giovanna Masala, Vittorio Krogh, Gabriella Iannuzzo, Rosario Tumino, Lorenzo Milani, Guri Skeie, Esther Ubago-Guisado, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Suzanne Janzi, Linda Eriksson, Heinz Freisling, Alicia K. Heath, Sabina Rinaldi, Antonio Agudo
Summary: This study found that consumption of sweetened beverages was associated with an increased risk of differentiated thyroid cancer, while a dietary pattern characterized by alcohol consumption was associated with a decreased risk of thyroid cancer.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Oncology
Alessandra Macciotta, Alberto Catalano, Maria Teresa Giraudo, Elisabete Weiderpass, Pietro Ferrari, Heinz Freisling, Sandra M. Colorado-Yohar, Carmen Santiuste, Pilar Amiano, Alicia K. Heath, Heather A. Ward, Sofia Christakoudi, Paolo Vineis, Deependra Singh, Salvatore Vaccarella, Matthias B. Schulze, Anouk E. Hiensch, Evelyn M. Monninkhof, Verena Katzke, Rudolf Kaaks, Rosario Tumino, Fulvio Lazzarato, Lorenzo Milani, Antonio Agudo, Christina C. Dahm, Laura Baglietto, Vittorio Perduca, Gianluca Severi, Sara Grioni, Salvatore Panico, Eva Ardanaz, Kristin B. Borch, Faith O. Benebo, Tonje Braaten, Maria-Jose Sanchez, Claudia Giachino, Carlotta Sacerdote, Fulvio Ricceri
Summary: This study examines the association between educational level and cancer incidence and finds that individuals with lower education have a higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, while having a lower risk of melanoma and breast cancer (in post-menopausal women). The study also suggests that specific lifestyle behaviors may explain part of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Yahya Mahamat-Saleh, Marie Al-Rahmoun, Gianluca Severi, Reza Ghiasvand, Marit B. Veierod, Saverio Caini, Domenico Palli, Edoardo Botteri, Carlotta Sacerdote, Fulvio Ricceri, Marko Lukic, Maria J. Sanchez, Valeria Pala, Rosario Tumino, Paolo Chiodini, Pilar Amiano, Sandra Colorado-Yohar, Maria-Dolores Chirlaque, Eva Ardanaz, Catalina Bonet, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Kim Overvad, Christina C. Dahm, Christian S. Antoniussen, Anne Tjonneland, Cecilie Kyro, Bas Bueno-de-Mesquita, Jonas Manjer, Malin Jansson, Anders Esberg, Nagisa Mori, Pietro Ferrari, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Marina Kvaskoff
Summary: Experimental evidence suggests that alcohol is a risk factor for skin cancer, although epidemiological studies have produced inconsistent results. This study, conducted on participants from 10 European countries over a 15-year follow-up, found a positive association between alcohol intake and the risk of squamous-cell carcinoma, basal-cell carcinoma, and melanoma. The associations were stronger in men and more modest in women.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Alessandra Allione, Clara Viberti, Ilaria Cotellessa, Chiara Catalano, Elisabetta Casalone, Giovanni Cugliari, Alessia Russo, Simonetta Guarrera, Dario Mirabelli, Carlotta Sacerdote, Marco Gentile, Fabian Eichelmann, Matthias B. Schulze, Sophia Harlid, Anne Kirstine Eriksen, Anne Tjonneland, Martin Andersson, Martijn E. T. Dolle, Heleen Van Puyvelde, Elisabete Weiderpass, Miguel Rodriguez-Barranco, Antonio Agudo, Alicia K. Heath, Maria-Dolores Chirlaque, Therese Truong, Dzevka Dragic, Gianluca Severi, Sabina Sieri, Torkjel M. Sandanger, Eva Ardanaz, Paolo Vineis, Giuseppe Matullo
Summary: This study identified nine differentially methylated CpGs associated with malignant pleural mesothelioma (MPM) through DNA methylation analysis, and these CpGs can serve as noninvasive biomarkers for the early detection of cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Nena Karavasiloglou, David J. Hughes, Neil Murphy, Lutz Schomburg, Qian Sun, Vartiter Seher, Sabine Rohrmann, Elisabete Weiderpass, Anne Tjonneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kuhn, Matthias B. Schulze, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Jeroen W. G. Derksen, Guri Skeie, Anette Hjartaker, Cristina Lasheras, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Bethany Van Guelpen, Bjorn Gylling, Kathryn E. Bradbury, Keren Papier, Heinz Freisling, Elom K. Aglago, Amanda J. Cross, Elio Riboli, Dagfinn Aune, Marc J. Gunter, Mazda Jenab
Summary: Two large European cohort studies found that circulating calcium concentrations were associated with colorectal cancer risk. In the EPIC cohort, total serum calcium was not associated with colorectal cancer, while in the UK-BB cohort, serum ionized calcium was inversely associated with colorectal cancer risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Urology & Nephrology
Adela Castello, Miguel Rodriguez-Barranco, Beatriz Perez-Gomez, Maria Dolores Chirlaque, Catalina Bonet, Pilar Amiano, Eva Ardanaz, Jose Maria Huerta, Raul Zamora-Ros, Jose Ramon Quiros, Aurelio Barricarte-Gurrea, Marina Pollan, Maria-Jose Sanchez
Summary: The study investigated the association between three dietary patterns (Western, Prudent, and Mediterranean) and prostate cancer risk. The findings suggest that a high adherence to Prudent and Mediterranean dietary patterns is not sufficient to prevent prostate cancer, and reducing reliance on a Western-type diet appears to be necessary.
Article
Multidisciplinary Sciences
Michelle C. Turner, Esther Gracia-Lavedan, Kyriaki Papantoniou, Nuria Aragones, Gemma Castano-Vinyals, Trinidad Dierssen-Sotos, Pilar Amiano, Eva Ardanaz, Alba Marcos-Delgado, Ana Molina-Barcelo, Juan Alguacil, Yolanda Benavente, Thalia Belmonte, Jose J. Jimenez-Moleon, Rafael Marcos-Gragera, Beatriz Perez, Ines Gomez-Acebo, Marina Pollan, Manolis Kogevinas
Summary: There is no clear association between habitual sleep duration, timing, and specific sleep problems, and breast or prostate cancer risk. However, there is a significant positive association between habitual siestas and breast cancer risk, which strengthens with increased frequency or duration. Recent sleep problems are also significantly associated with both breast and prostate cancer risk, but sleep problems at age 40 years are not.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Conchi Moreno-Iribas, Yugo Floristan, Irene Iniesta, Eva Ardanaz, Marcela Guevara, Josu Delfrade
Summary: This study presents mortality indicators in Navarre, Spain for 2020, including life expectancy at birth, excess mortality, and mortality from COVID-19 and other causes. The results show a decrease in life expectancy compared to 2019, mainly due to COVID-19. Excess mortality was highest among individuals aged 85 and above, and COVID-19 accounted for the majority of deaths in people over 75. Additionally, there was a significant decrease in mortality among individuals affected by diseases such as dementia during the COVID-19 pandemic.
ANALES DEL SISTEMA SANITARIO DE NAVARRA
(2022)
Article
Oncology
Anja M. M. Sedlmeier, Vivian Viallon, Pietro Ferrari, Laia Peruchet-Noray, Emma Fontvieille, Amina Amadou, Nazlisadat Seyed Khoei, Andrea Weber, Hansjoerg Baurecht, Alicia K. K. Heath, Kostas Tsilidis, Rudolf Kaaks, Verena Katzke, Elif Inan-Eroglu, Matthias B. B. Schulze, Kim Overvad, Catalina Bonet, Esther Ubago-Guisado, Maria-Dolores Chirlaque, Eva Ardanaz, Aurora Perez-Cornago, Valeria Pala, Rosario Tumino, Carlotta Sacerdote, Fabrizio Pasanisi, Kristin B. B. Borch, Charlotta Rylander, Elisabete Weiderpass, Marc J. J. Gunter, Beatrice Fervers, Michael F. F. Leitzmann, Heinz Freisling
Summary: This study suggests that different body shape phenotypes are positively associated with the incidence of various cancers, including overall cancer and site-specific cancers.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Karine Alcala, Daniela Mariosa, Karl Smith-Byrne, Dariush Nasrollahzadeh Nesheli, Robert Carreras-Torres, Eva Ardanaz Aicua, Nicola P. Bondonno, Catalina Bonet, Mattias Brunstrom, Bas Bueno-de-Mesquita, Maria-Dolores Chirlaque, Sofia Christakoudi, Alicia K. Heath, Rudolf Kaaks, Verena Katzke, Vittorio Krogh, Borje Ljungberg, Richard M. Martin, Anne May, Olle Melander, Domenico Palli, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Tanja Stocks, Anne Tjonneland, Ruth C. Travis, Roel Vermeulen, Stephen Chanock, Mark Purdue, Elisabete Weiderpass, David Muller, Paul Brennan, Mattias Johansson
Summary: Diastolic blood pressure (DBP) appears to play an important role in the etiology of renal cell carcinoma (RCC), while the association between systolic blood pressure (SBP) and RCC risk is less clear and seems to be dependent on DBP.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)