Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Miguel angel Gonzalez-Moles, Fernanda Weber Mello, Jose V. Bagan, Saman Warnakulasuriya
Summary: This study investigated the malignant transformation of oral proliferative verrucous leukoplakia, finding that females and gingiva were more commonly affected. The pooled proportion of malignant transformation was 43.87%, with conventional squamous cell carcinoma being the most frequent histopathological subtype. No conclusive results were found between malignant transformation and sex, age, tobacco, or alcohol consumption.
Review
Oncology
Yan Huang, Qiufang Zhang, Zhenzhen Guo, Guanhong Deng, Ruibin Chen, Yanfen Zheng
Summary: This study systematically searched and analyzed the literature on potential saliva and serum biomarkers for oral leukoplakia (OL) malignant transformation. The results showed that IL-6 and TNF-alpha in saliva, as well as LSA and TSA levels in serum, have statistically significant differences in distinguishing healthy controls, OL patients, and oral cancer patients.
Review
Oncology
Pablo Ramos-Garcia, Miguel Angel Gonzalez-Moles, Saman Warnakulasuriya
Summary: This study evaluated the evidence on the predictive value of p53 overexpression as a biomarker for malignant transformation risk in oral potentially malignant disorders (OPMD). The findings indicated a significant association between p53 overexpression and a 2-fold increased risk of malignant transformation in OPMD, particularly in cases of leukoplakia. The use of the DO7 antibody, high concentration, long-term incubation, and low temperature yielded better results in immunohistochemical analysis. Importantly, the association between p53 overexpression and oral cancer risk was independent of the presence and severity of epithelial dysplasia.
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Maria del Mar Roca-Rodriguez, Manuel Aguilar-Diosdado, Miguel Angel Gonzalez-Moles
Summary: The study revealed that patients with diabetes mellitus have a higher prevalence and greater chance of developing oral cancer and potentially malignant oral disorders compared to non-diabetic patients, with higher mortality rates for diabetic patients with oral cancer.
Review
Dentistry, Oral Surgery & Medicine
Cecilie D. de la Cour, Cecilie D. Sperling, Federica Belmonte, Stina Syrjanen, Susanne K. Kjaer
Summary: The study aimed to provide pooled estimates of HPV prevalence in oral potentially malignant disorders and found an overall HPV prevalence of 22.5% with significant heterogeneity between studies. The prevalence appeared to be similar across subgroups and independent of epithelial dysplasia.
Review
Dentistry, Oral Surgery & Medicine
Jing-Yao Guan, Yong-Hua Luo, Ye-Yu Lin, Zhou-Yang Wu, Jing-Yi Ye, Si-Ming Xie, Jin Li
Summary: This meta-analysis aimed to assess the rate of malignant transformation (MT) of oral leukoplakia (OL) and to study potential risk factors for the MT of OL into oral squamous cell carcinoma (OSCC). The pooled proportion of OL MT for the total population described in the selected studies was 7.20%. Nonhomogeneous type lesions, higher grades of dysplasia, the location of the lesion (tongue and multifocal), and female sex had significant effects on the MT of OL. Patients with significant MT risk factors should be subjected to regular follow-up and observation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Omar Kujan, Fernanda Weber Mello, Saman Warnakulasuriya
Summary: This systematic review aimed to determine the proportion of patients developing oral carcinomas following a diagnosis of oral submucous fibrosis (OSF). The meta-analysis showed that close to 4% of OSF patients may develop oral cancer, with cases of oral epithelial dysplasia having a higher potential for malignant transformation.
Review
Oncology
Miguel Angel Gonzalez-Moles, Saman Warnakulasuriya, Pablo Ramos-Garcia
Summary: Proliferative verrucous leukoplakia patients with oral carcinoma (PVL-OC) have a lower mortality rate compared to conventional oral cancer, indicating favorable prognostic parameters.
Review
Microbiology
Alejandro Lorenzo-Pouso, Alba Perez-Jardon, Vito Carlo Alberto Caponio, Francesca Spirito, Cintia M. Chamorro-Petronacci, Oscar Alvarez-Calderon-Iglesias, Pilar Gandara-Vila, Lorenzo Lo Muzio, Mario Perez-Sayans
Summary: The aim of this study was to evaluate the evidence on the malignant transformation (MT) of chronic hyperplastic candidiasis (CHC) and determine the variables influencing cancer development. A total of nine studies were included for analysis, and the overall MT rate for CHC was 12.1%. However, it remains complex to determine whether CHC is a potentially malignant disorder, and further research is needed.
Review
Oncology
Almas Binnal, Jyothi Tadakamadla, Gururaghavendran Rajesh, Santosh Kumar Tadakamadla
Summary: This study evaluated the effectiveness of Photodynamic Therapy (PDT) in treating patients with Oral Potentially Malignant Disorders (OPMDs). The results showed that more than half of the patients achieved complete response (CR) and over 90% responded positively to the treatment. PDT was found to be most effective in treating oral dysplasias and actinic cheilitis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Oncology
Gaspare Palaia, Amelia Bellisario, Riccardo Pampena, Roberto Pippi, Umberto Romeo
Summary: PVL, a rare subtype of oral leukoplakia, has a high risk of malignant transformation, with almost 50% progressing to OSCC. Female patients, especially elderly non-smokers and non-drinkers, are at higher risk for this transformation.
Review
Medicine, General & Internal
Vignesh Murthy, Petros Mylonas, Barbara Carey, Sangeetha Yogarajah, Damian Farnell, Owen Addison, Richard Cook, Michael Escudier, Marcio Diniz-Freitas, Jacobo Limeres, Luis Monteiro, Luis Silva, Jean-Cristophe Fricain, Sylvain Catros, Mathilde Fenelon, Giovanni Lodi, Niccolo Lombardi, Vlaho Brailo, Raj Ariyaratnam, Jose Lopez-Lopez, Rui Albuquerque
Summary: Oral submucous fibrosis (OSF) is a chronic progressive condition that can potentially transform into malignant disease. A review of literature revealed an overall 6% risk of malignant transformation, with variations in proportion among different ethnicities and cohorts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Luis Monteiro, Fernanda Weber Mello, Saman Warnakulasuriya
Summary: A systematic review evaluated biomarkers related to oral leukoplakia, identifying some biomarkers associated with future cancer risk in OL patients. Heterogeneity and lack of standardized reporting were identified as issues in the studies.
Review
Pathology
Daniel Vitor de Souza, Barbara dos Anjos Rosario, Wilton Mitsunari Takeshita, Milena de Barros Viana, Marcia Regina Nagaoka, Jean Nunes dos Santos, Daniel Araki Ribeiro
Summary: This systematic review and meta-analysis evaluated the feasibility of using the micronucleus assay in oral exfoliated cells as a biomarker for predicting cancer risk in individuals with oral potentially malignant disorders. The results showed a significant difference in oral micronucleated cells between patients with OPMDs and the control group, indicating a positive mutagenic response in oral cells of OPMDs patients. However, the majority of studies were considered weak with a high risk of bias, and thus the validity of the micronucleus assay as a biomarker in individuals with OPMDs has not been confirmed.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Fengji Li, Lin Qiu, Qian Gao, Liguang Yu, Han Liu, Zhijun Xue, Anqi Tao
Summary: This study aimed to identify key genes for the malignant transformation of oral leukoplakia (OLK) using the Gene Expression Omnibus (GEO) database and experiments. The GEO database was used to screen OLK malignant transformation-related genes, which were then validated through bioinformatic analyses and experiments. The results identified LAPTM4B, NR3C1, and COX6A1 as potential biomarkers for the diagnosis and treatment of OLK malignant transformation.
Article
Dentistry, Oral Surgery & Medicine
Irene Lafuente-Ibanez de Mendoza, Jose Manuel Aguirre-Urizar, Veronica Villatoro-Ugalde, Jose-Julio Magana-Quinones, Jessica Lana-Ojeda, Adalberto Mosqueda-Taylor
Summary: POKC is a rare gingival lesion that may originate from remnants of dental lamina or basal cells of the gingival epithelium, and it presents similar histopathological features compared to intraosseous OKC.
Review
Dentistry, Oral Surgery & Medicine
Teresa De Porras-Carrique, Pablo Ramos-Garcia, Manuel Aguilar-Diosdado, Saman Warnakulasuriya, Miguel Angel Gonzalez-Moles
Summary: There is a high prevalence and frequent association between OLP and autoimmune disorders, especially thyroid disease and diabetes mellitus.
Article
Biochemistry & Molecular Biology
Luis Monteiro, Barbas do Amaral, Leonor Delgado, Fernanda Garces, Filomena Salazar, Jose Julio Pacheco, Carlos Lopes, Saman Warnakulasuriya
Summary: The study found that the expression levels of CD44v6, p53, p73, and podoplanin increase gradually along with the progression of oral leukoplakias. Furthermore, high levels of podoplanin expression were found to be associated with an increased risk of malignant transformation.
Review
Medicine, General & Internal
A. Thirumal Raj, Kamran Habib Awan, Shankargouda Patil, Peter Morgan, Saman Warnakulasuriya
Summary: Oral warty dyskeratoma is a rare benign lesion that can be misdiagnosed as carcinoma due to its clinical and histopathological resemblance. The most common site of occurrence is the alveolar ridge, and tobacco is the most commonly associated risk factor. Lack of molecular data hinders the understanding of the etiopathogenesis of this lesion.
Review
Oncology
Miguel Angel Gonzalez-Moles, Saman Warnakulasuriya, Maria Lopez-Ansio, Pablo Ramos-Garcia
Summary: This scoping review aims to assess the scientific evidence on cancer hallmarks in oral and oropharyngeal squamous cell carcinomas and oral potentially malignant disorders. It highlights the gaps in knowledge and suggests future research directions to improve prediction, diagnosis, and prognosis of these diseases. The importance of these hallmarks in oral and oropharyngeal carcinoma is yet to be comprehensively analyzed.
Article
Medicine, General & Internal
Veronique Bouvard, Suzanne T. Nethan, Deependra Singh, Saman Warnakulasuriya, Ravi Mehrotra, Anil K. Chaturvedi, Tony Hsiu-Hsi Chen, Olalekan A. Ayo-Yusuf, Prakash C. Gupta, Alexander R. Kerr, Wanninayake M. Tilakaratne, Devasena Anantharaman, David Conway, Ann Gillenwater, Newell W. Johnson, Luiz P. Kowalski, Maria E. Leon, Olena Mandrik, Toru Nagao, Vinayak M. Prasad, Kunnambath Ramadas, Felipe Roitberg, Pierre Saintigny, Rengaswamy Sankaranarayanan, Alan R. Santos-Silva, Dhirendra N. Sinha, Patravoot Vatanasapt, Rosnah B. Zain, Beatrice Lauby-Secretan
Summary: An expert panel review by the International Agency for Research on Cancer (IARC) suggests that smoking, smokeless tobacco use, areca nut exposure, and heavy alcohol consumption are major contributors to oral cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Oncology
Irene Lafuente-Ibanez de Mendoza, Jose Manuel Aguirre-Urizar
Review
Public, Environmental & Occupational Health
Adalberto M. Filho, Michelle C. Turner, Saman Warnakulasuriya, David B. Richardson, Bayan Hosseini, Farin Kamangar, Akram Pourshams, Vikash Sewram, Deirdre Cronin-Fenton, Arash Etemadi, Deborah C. Glass, Afarin Rahimi-Movaghar, Mahdi Sheikh, Reza Malekzadeh, Mary K. Schubauer-Berigan
Summary: The International Agency for Research on Cancer (IARC) recently evaluated the carcinogenicity of opium consumption. This study conducted an extended systematic review and meta-analysis to assess the relationship between opium consumption and selected cancers. The findings provide robust evidence of an adverse association between opium consumption and cancers of the urinary bladder, larynx, lung, esophagus, pancreas, and stomach.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lucas Lacerda de Souza, Felipe Paiva Fonseca, Anna Luiza Damaceno Araujo, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Syed Ali Khurram, Luiz Paulo Kowalski, Harim Tavares dos Santos, Saman Warnakulasuriya, James Dolezal, Alexander. T. T. Pearson, Alan Roger Santos-Silva
Summary: Oral potentially malignant disorders are precursor lesions with the potential to transform into oral cancer. Risk factors contribute to the development of these disorders and the risk of malignant transformation. Early diagnosis is crucial for improving prognosis, and the integration of machine learning into clinical examination has shown promise in the detection of early cancer.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Letter
Oncology
Saman Warnakulasuriya
Article
Dentistry, Oral Surgery & Medicine
Irosha Perera, Hemantha Amarasinghe, Ruwan D. Jayasinghe, Iresha Udayamalee, Nadeena Jayasuriya, Saman Warnakulasuriya, Newell W. Johnson
Summary: Oral cancer is the most common malignancy among Sri Lankan males and a top 10 cancer among females. Despite being preventable and controllable, contextual factors and social determinants consistently hinder progress in addressing oral cancer inequalities. This review aims to critically analyze oral cancer epidemiology and inequalities in Sri Lanka, using multiple data sources.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya
Review
Dentistry, Oral Surgery & Medicine
Lady P. A. Arboleda, Thais C. E. Pereira, Joel B. Epstein, Cesar A. Migliorati, Saman Warnakulasuriya, Marcio Diniz-Freitas, Marcio A. Lopes, Alan R. Santos-Silva
Summary: This scoping review examines the communication of oral potentially malignant disorders (OPMDs) and their impacts on patients. Five publications were analyzed and differences in study design, population, OPMDs assessed, and outcomes of professional-patient communication were found. There is a need to standardize strategies for OPMD communication as it could lead to better clinical outcomes. Although further research is needed, a brief list of recommended communication aspects is proposed.
Review
Medicine, General & Internal
Kalpani Senevirathna, Roshan Pradeep, Yovanthi Anurangi Jayasinghe, Shalindu Malshan Jayawickrama, Rasika Illeperuma, Saman Warnakulasuriya, Ruwan Duminda Jayasinghe
Summary: Oral cancers are common in Southeast Asia due to the habit of betel quid and smokeless tobacco use. Areca nut, the main ingredient in betel quid, contains alkaloids that have been associated with addiction and carcinogenicity. Recent studies have shown cellular and molecular effects induced by areca nut, including promoting epithelial-mesenchymal transition, autophagy initiation, tissue hypoxia, genotoxicity, cytotoxicity, and cell death. Clinical research also supports these harmful effects. The carcinogenicity of areca nut based on experimental studies is discussed in this review.
CLINICS AND PRACTICE
(2023)
Article
Dentistry, Oral Surgery & Medicine
A-M Garcia-de-la-Fuente, I. Lafuente-Ibanez-de-Mendoza, M-J Lartitegui-Sebastian, X. Marichalar-Mendia, M-A Echebarria-Goikouria, J-M Aguirre-Urizar
Summary: This study aimed to determine the oral health of patients diagnosed with Parkinson's disease (PD) and establish a specific preventive oral health program. The results revealed that PD patients had a higher consumption of daily sweets and antidepressant drugs, poorer interdental hygiene, and a higher plaque index. PD patients also experienced more frequent drooling, xerostomia, hyposialia, dysphagia, hypogeusia/dysgeusia, and chewing difficulty. These oral disorders in PD patients indicate the need for a specific preventive protocol and may serve as diagnostic alerts or indicators of disease progression.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2022)
