Inhibition of PAI‐1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome

(2020) Hekmat B. Khoukaz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance

(2020) Shinichiro Hosaka et al.   Frontiers in Pharmacology

DNA methylation GrimAge strongly predicts lifespan and healthspan

(2019) Ake T. Lu et al.   Aging-US

A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes

(2019) Gina M. Coudriet et al.   AMERICAN JOURNAL OF PATHOLOGY

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

(2019) Zachary J. Ward et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonalcoholic Fatty Liver Disease in Humans Is Associated with Increased Plasma Endotoxin and Plasminogen Activator Inhibitor 1 Concentrations and with Fructose Intake

(2018) Sabine Thuy et al.   JOURNAL OF NUTRITION

PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

(2018) Lin Wang et al.   Frontiers in Pharmacology

A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice

(2016) Lingjuan Piao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

(2014) M. Eren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N ω -Nitro- l -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence

(2013) Amanda E. Boe et al.   CIRCULATION

Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2013) An Verrijken et al.   HEPATOLOGY

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice

(2010) Anne S. Henkel et al.   JOURNAL OF LIPID RESEARCH

Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease

(2009) Silvia Sookoian et al.   ATHEROSCLEROSIS

Homocysteine Supplementation Attenuates the Unfolded Protein Response in a Murine Nutritional Model of Steatohepatitis

(2009) Anne S. Henkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NASH Predicts Plasma Inflammatory Biomarkers Independently of Visceral Fat in Men

(2008) Giovanni Targher et al.   Obesity