Article
Multidisciplinary Sciences
Alexander L. Ling, Isaac H. Solomon, Ana Montalvo Landivar, Hiroshi Nakashima, Jared K. Woods, Andres Santos, Nafisa Masud, Geoffrey Fell, Xiaokui Mo, Ayse S. Yilmaz, James Grant, Abigail Zhang, Joshua D. Bernstock, Erickson Torio, Hirotaka Ito, Junfeng Liu, Naoyuki Shono, Michal O. Nowicki, Daniel Triggs, Patrick Halloran, Raziye Piranlioglu, Himanshu Soni, Brittany Stopa, Wenya Linda Bi, Pierpaolo Peruzzi, Ethan Chen, Seth W. Malinowski, Michael C. Prabhu, Yu Zeng, Anne Carlisle, Scott J. Rodig, Patrick Y. Wen, Eudocia Quant Lee, Lakshmi Nayak, Ugonma Chukwueke, L. Nicolas Gonzalez Castro, Sydney D. Dumont, Tracy Batchelor, Kara Kittelberger, Ekaterina Tikhonova, Natalia Miheecheva, Dmitry Tabakov, Nara Shin, Alisa Gorbacheva, Artemy Shumskiy, Felix Frenkel, Estuardo Aguilar-Cordova, Laura K. Aguilar, David Krisky, James Wechuck, Andrea Manzanera, Chris Matheny, Paul P. Tak, Francesca Barone, Daniel Kovarsky, Itay Tirosh, Mario L. Suva, Kai W. Wucherpfennig, Keith Ligon, David A. Reardon, E. Antonio Chiocca
Summary: A phase I clinical trial in patients with rGBM showed that treatment with an oncolytic herpes virus (oHSV) enhanced anticancer immune responses, particularly in individuals with serology matching the virus.
Article
Chemistry, Multidisciplinary
Xinyuan Jia, Lizheng Wang, Xinyao Feng, Wenmo Liu, Xupu Wang, Fangshen Li, Xinyao Liu, Jiahao Yu, Bin Yu, Xianghui Yu
Summary: Cell membrane-coated oncolytic adenoviruses improve targeted infectivity on GBM cells and avoid preexisting immunity, providing a promising therapeutic strategy for glioma.
Review
Biochemistry & Molecular Biology
Kaiyi Yang, Shenghui Feng, Zhijun Luo
Summary: Prostate cancer is a common and deadly cancer in males. Androgen-deprivation therapy is effective in early stage tumors, but many cases progress to metastatic castration-resistant prostate cancer. Existing clinical treatments for advanced prostate cancer have limitations, but gene therapy and viral therapy show promise in controlling the disease.
Review
Biochemistry & Molecular Biology
Shyambabu Chaurasiya, Yuman Fong, Susanne G. Warner
Summary: Oncolytic viruses are a new class of therapeutics that have shown promise in clinical trials, although their anti-tumor efficacy as monotherapy is modest. Most oncolytic viruses are well tolerated, even in immune-suppressed patients, at the currently defined highest feasible doses. Enhancing the potency of oncolytic viruses is necessary for more viruses to be used effectively in clinical settings, thus they are being studied in combination with other therapies for higher therapeutic benefits.
Review
Oncology
Margarita Kamynina, Salome Tskhovrebova, Jawad Fares, Peter Timashev, Anastasia Laevskaya, Ilya Ulasov
Summary: Glioblastoma (GBM) is the most common and aggressive brain tumor with limited therapeutic options. Gene therapies using self-replicating oncolytic viruses may advance GBM treatment. Autophagy in glioblastoma plays a dual role in cell death and survival.
Article
Nanoscience & Nanotechnology
Xiaoxiao Liu, Jinliang Xu, Tingting Yao, Junqiang Ding, Sha Li, Runping Su, Hanchang Zhang, Hui Li, Qi Yue, Xihui Gao
Summary: Glioblastoma, a common brain tumor with high recurrence rate and mortality, has limited response to immunotherapy due to low immunogenicity and immune cell infiltration. A solution is the oncolytic adenovirus reservoir (OAR), which selectively replicates in tumor cells while promoting antitumor immune responses. OARs showed sustained release and efficient lysis of tumor cells both in vitro and in vivo. In a mouse glioblastoma model, OARs induced dendritic cell maturation, facilitated tumor recruitment, and promoted infiltration of cytotoxic T lymphocytes, leading to specific antitumor immune responses and improved animal survival.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Tomoki Todo, Hirotaka Ito, Yasushi Ino, Hiroshi Ohtsu, Yasunori Ota, Junji Shibahara, Minoru Tanaka
Summary: A crucial clinical trial demonstrates that repeated tumor-administration of oncolytic herpes virus G47 Increment in residual or recurrent glioblastoma leads to improved survival rates and a safe profile.
Review
Biochemistry & Molecular Biology
Klaus Mantwill, Florian Gerhard Klein, Dongbiao Wang, Sruthi Vasantamadhava Hindupur, Maximilian Ehrenfeld, Per Sonne Holm, Roman Nawroth
Summary: Oncolytic adenovirus therapy is an important novel treatment option for combating various cancers by exploiting the virus's replication and induction of cell death. Modifications in the adenoviral vectors contribute to restricting the virus's specificity and enhancing its therapeutic effects, leading to advancements in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Peiwen Wang, Junwen Zhang, Qing Zhang, Fusheng Liu
Summary: The use of mesenchymal stem cells (MSCs) as vehicles of oncolytic adenovirus (oAd) is a promising strategy for enhancing the treatment efficacy of glioblastoma multiforme (GBM) by improving viral infiltration and protection from the host immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Chao Zhou, Qi Chen, Yun Chen, Cheng-Feng Qin
Summary: This review summarizes the current status of oncolytic viruses for GBM treatment, with a focus on the potential of Zika virus as a therapeutic virus for GBM and the associated advantages and challenges for its clinical development.
DNA AND CELL BIOLOGY
(2023)
Article
Virology
Lili Deng, Xue Yang, Yuedi Ding, Jun Fan, Ying Peng, Dong Xu, Biao Huang, Zhigang Hu
Summary: In this study, a recombinant vaccinia virus, VG9-IL-24, was constructed, which selectively infected hepatocellular carcinoma cells and induced apoptosis, showing promising antitumor effects. Additionally, VG9-IL-24 blocked the cell cycle progression and suppressed tumor growth.
Review
Oncology
Isobel P. Taylor, J. Alejandro Lopez
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a common and difficult-to-treat cancer. Surgical resection and chemotherapy are the standard treatments, but the clinical outcomes are still poor. This paper reviews the clinical trials of conditionally-replicative adenoviruses in pancreatic cancer, providing a summary of the current literature and future prospects of this therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomoki Todo, Yasushi Ino, Hiroshi Ohtsu, Junji Shibahara, Minoru Tanaka
Summary: This study evaluated the safety and efficacy of G47 Delta in patients with recurrent/progressive glioblastoma. The results showed that G47 Delta was safe and could prolong the survival of patients with this type of tumor. Pathological and radiological findings suggested that G47 Delta destroyed tumor cells through viral replication and lymphocyte infiltration.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Zhongbing Qi, Xiangyu Long, Jiyan Liu, Ping Cheng
Summary: Glioblastoma is a highly aggressive form of brain tumor that responds poorly to conventional therapies. Oncolytic virus therapy shows promise in improving therapeutic efficacy, but limitations as a monotherapy need to be overcome.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Jinjian Li, Qing Meng, Xuehui Zhou, Hehe Zhao, Kun Wang, Huanjiang Niu, Yirong Wang
Summary: Glioma, the most common intracranial malignant tumor, is a significant health challenge due to its impact on brain function. The current treatments, including surgery, radiotherapy, and chemotherapy, have limited efficacy. Researchers have explored the use of oncolytic viruses (OVs) as a novel treatment approach. OVs work by activating the immune system and inducing tumor cell apoptosis. However, the classification of OVs is still unclear, and the clinical application faces challenges.
Article
Endocrinology & Metabolism
Uchenna Cosmas Ugwu, Osmond Chukwuemeka Ene
Summary: The study found that outpatient diabetic elderly persons in Nigeria have high knowledge (87%), positive attitude (76%), and good practice (82%) towards diabetes mellitus. Significant differences were found within age and education level variables, while no significant difference was found within the gender variable.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Neuroimaging
Stephen R. Chen, Melissa M. Chen, Chibawanye Ene, Frederick F. Lang, Peter Kan
Summary: This study for the first time utilizes perfusion guidance to enhance the precision of glioblastoma treatment, improving targeted delivery of therapeutic agents through MRI imaging and volumetric perfusion imaging.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Oncology
Naiara Martinez-Velez, Virginia Laspidea, Marta Zalacain, Sara Labiano, Marc Garcia-Moure, Montse Puigdelloses, Lucia Marrodan, Marisol Gonzalez-Huarriz, Guillermo Herrador, Daniel de la Nava, Iker Ausejo-Mauleon, Juan Fueyo, Candelaria Gomez-Manzano, Ana Patino-Garcia, Marta M. Alonso
Summary: Osteosarcoma is an aggressive bone tumor that primarily affects pediatric patients. Despite extensive research, the outcomes for patients with metastatic or therapy-resistant osteosarcoma have remained poor. This study investigated the use of Delta-24-ACT, a replicative oncolytic adenovirus, to target and kill osteosarcoma cells. In vitro and in vivo experiments showed that Delta-24-ACT effectively killed osteosarcoma cells and had antitumor effects against primary tumors and metastases in a mouse model. Furthermore, Delta-24-ACT treatment increased the median survival time of the mice without any observed toxicity. These findings suggest that Delta-24-ACT could be a promising therapeutic strategy for patients with local and metastatic osteosarcoma.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Erik H. P. van Putten, Anne Kleijn, Victor W. van Beusechem, David Noske, Cor H. J. Lamers, Anna L. de Goede, Sander Idema, Daphna Hoefnagel, Jenneke J. Kloezeman, Juan Fueyo, Frederick F. Lang, Charlotte E. Teunissen, Rene M. Vernhout, Cathy Bakker, Winald Gerritsen, David T. Curiel, Arnold Vulto, Martine L. M. Lamfers, Clemens M. F. Dirven
Summary: The purpose of this study was to test the safety of locally delivering Delta24-RGD, an oncolytic adenovirus, through convection enhanced delivery (CED) in the tumor and surrounding brain of patients with recurrent glioblastoma. The results showed that Delta24-RGD was safe and feasible, induced a local inflammatory reaction, and demonstrated promising clinical responses.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Cosmin-Victor Ene, Ilinca Nicolae, Bogdan Geavlete, Petrisor Geavlete, Corina Daniela Ene
Summary: Inflammatory processes play a crucial role in the development of prostate tumors. Modulating the expression and activity of the cytokine Interleukin-6 may provide a means of preventing or improving these pathologies.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Bingcheng Jiang, Cameron Murray, Bonnie L. Cole, J. N. Mark Glover, Gordon K. Chan, Jean Deschenes, Rajam S. Mani, Sudip Subedi, John D. Nerva, Anthony C. Wang, Christina M. Lockwood, Heather C. Mefford, Sarah E. S. Leary, Jeffery G. Ojemann, Michael Weinfeld, Chibawanye Ene
Summary: A study reveals that mutations in the PNKP gene are associated with the development of brain tumors in patients with Microcephaly, Seizures, and Developmental Delay (MSCZ). These mutations inactivate PNKP, leading to defective DNA repair and increased risk of oncogenic transformation.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Chibawanye I. Ene, Sherise D. Ferguson
Summary: Brain metastasis is a common type of intracranial tumor that typically occurs in advanced cancer patients, resulting in a poor prognosis. However, advancements in systemic therapy, radiation techniques, and personalized treatment have brought hope to these patients. Surgical resection plays a significant role in the management of brain metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Virginia Laspidea, Montserrat Puigdelloses, Sara Labiano, Lucia Marrodan, Marc Garcia-Moure, Marta Zalacain, Marisol Gonzalez-Huarriz, Naiara Martinez-Velez, Iker Ausejo-Mauleon, Daniel de la Nava, Guillermo Herrador-Canete, Javier Marco-Sanz, Elisabeth Guruceaga, Carlos E. de Andrea, Maria Villalba, Oren Becher, Massimo Squatrito, Veronica Matia, Jaime Gallego Perez-Larraya, Ana Patino-Garcia, Sumit Gupta, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso
Summary: The study found that Delta-24-ACT treatment with oncolytic adenovirus can significantly improve the survival rate of mice with DIPG, leading to long-term survival and the development of immunological memory. In addition, this treatment method is safe and has no toxic side effects, and can modulate tumor-immune content.
Article
Oncology
Elshad Hasanov, Debra Nana Yeboa, Mathew D. Tucker, Todd A. Swanson, Thomas Hendrix Beckham, Brian Rini, Chibawanye I. Ene, Merve Hasanov, Sophie Derks, Marion Smits, Shaan Dudani, Daniel Y. C. Heng, Priscilla K. Brastianos, Axel Bex, Sahin Hanalioglu, Jeffrey S. Weinberg, Laure Hirsch, Maria I. Carlo, Ayal Aizer, Paul David Brown, Mehmet Asim Bilen, Eric Lin Chang, Jerry Jaboin, James Brugarolas, Toni K. Choueiri, Michael B. Atkins, Bradley A. McGregor, Lia M. Halasz, Toral R. Patel, Scott G. Soltys, David F. McDermott, James Bradley Elder, Mustafa K. Baskaya, James B. Yu, Robert Timmerman, Michelle Miran Kim, Melike Mut, James Markert, Kathryn Beal, Nizar M. Tannir, George Samandouras, Frederick F. Lang, Rachel Giles, Eric Jonasch
Summary: Brain metastases are a challenging manifestation of renal cell carcinoma, and the optimal treatment approach remains unclear. This study aimed to improve patient care by establishing algorithms for the management of brain metastases through literature review and expert surveys.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Biochemistry & Molecular Biology
Ileana Adela Vacaroiu, Elena Cuiban, Bogdan Florin Geavlete, Valeriu Gheorghita, Cristiana David, Cosmin Victor Ene, Catalin Bulai, Gabriela Elena Lupusoru, Mircea Lupusoru, Andra Elena Balcangiu-Stroescu, Larisa Florina Feier, Ioana Sorina Simion, Daniela Radulescu
Summary: CKD is a significant risk factor for antimicrobial resistance and multi-drug resistance.
Review
Medicine, General & Internal
Catalin Bulai, Petrisor Geavlete, Cosmin-Victor Ene, Isabela Bulai, Razvan-Ionut Popescu, Cristian Mares, Corina Daniela Ene, Ana-Maria Punga, Bogdan Geavlete
Summary: Early detection of bladder cancer has a positive impact on prognosis. Various methods have been developed to detect bladder tumors, but their accuracy varies. This review aims to summarize the detection methods for bladder cancer and identify the most accurate combination of methods. Analysis of international guidelines reveals discrepancies and unresolved issues.
Article
Oncology
Hong Jiang, Dong Ho Shin, Yanhua Yi, Xuejun Fan, Joy Gumin, Jiasen He, Andrew G. Gillard, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Clinical Neurology
Yuzaburo Shimizu, Joy Gumin, Feng Gao, Anwar Hossain, Elizabeth J. Shpall, Akihide Kondo, Brittany C. Parker Kerrigan, Jing Yang, Daniel Ledbetter, Juan Fueyo, Candelaria Gomez-Manzano, Frederick F. Lang
Summary: The study investigated the feasibility of obtaining bone marrow-derived human mesenchymal stem cells (BM-hMSCs) from patients with recurrent malignant glioma previously treated with marrow-toxic chemotherapy. Results showed that patient-derived BM-hMSCs (PD-BM-hMSCs) could effectively deliver oncolytic viruses and eradicate human gliomas in vitro and in vivo.
JOURNAL OF NEUROSURGERY
(2022)