Therapeutic Delivery to Central Nervous System

? Direct administration of agents to bypass the BBB include implantable controlled-release polymer systems, intracavitary drug delivery, direct injection of viral vectors, and convection-enhanced delivery (CED). ? CED uses direct pump-mediated continuous infusion into the tumor bed or tumor adjacent brain, circumventing the BBB. This approach has shown promising results with infusion of immunotoxins,

Automated summary

Direct administration methods to bypass the BBB include various approaches, with convection-enhanced delivery showing promising results in infusion of immunotoxins.