Article
Radiology, Nuclear Medicine & Medical Imaging
Florence L. Chiang, Max Feng, Rebecca S. Romero, Larry Price, Crystal G. Franklin, Shengwen Deng, Jodie P. Gray, Fang F. Yu, Bundhit Tantiwongkosi, Susie Y. Huang, Peter T. Fox
Summary: The study defined the atrophy-based functional network model using coordinate-based meta-analysis, revealing the association of functional network disruption in multiple sclerosis and finding a strong positive correlation with clinical disability on resting-state functional MRI scans.
Review
Psychology, Experimental
Dan E. Hay, Sun Bleicher, Roy Azoulay, Yogev Kivity, Eva Gilboa-Schechtman
Summary: Belongingness is an important biopsychosocial system and challenges to belongingness have negative effects on affect and cognitions. The effects of overinclusion on positive affect and fundamental needs cognitions are positive, but smaller than the effects of exclusion.
COGNITION & EMOTION
(2023)
Article
Psychiatry
Donna J. Roybal, Victoria E. Cosgrove, Ryan Kelley, Rachel Smallwood Shoukry, Rose Marie Larios, Blake Novy, Kiki D. Chang, Amy S. Garrett
Summary: Preliminary data suggests that youth with bipolar disorder (BD) process social exclusion differently from healthy youth, focusing more on basic visual information rather than utilizing past experiences. This difference may contribute to social cognitive issues experienced by youth with BD, leading to more severe anxiety and mood symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neuroimaging
Leonardo Tozzi, Xue Zhang, Megan Chesnut, Bailey Holt-Gosselin, Carolina A. Ramirez, Leanne M. Williams
Summary: Resting-state functional connectivity changes within the default mode network (DMN) are associated with rumination in patients with major depressive disorder (MDD). While functional connectivity in the DMN Core is significantly reduced in MDD, connectivity within the DMPFC subsystem and between the Core and DMPFC subsystems is slightly reduced but not significant. Heterogeneity across samples suggests limitations in using reduced Core DMN connectivity as a clinical or prognostic marker for MDD.
NEUROIMAGE-CLINICAL
(2021)
Article
Medicine, General & Internal
Zoe Buerger, Veronika I. Mueller, Felix Hoffstaedter, Ute Habel, Ruben C. Gur, Christian Windischberger, Ewald Moser, Birgit Derntl, Lydia Kogler
Summary: Females and males differ in stress reactions and coping strategies. The connectivity between the amygdala and frontal regions plays a key role in stress coping. In this study, the effects of sex and stressor type on the connectivity of the amygdala and frontal regions were examined. Females showed stronger connectivity between the amygdala and certain frontal regions during social exclusion stress compared to achievement stress, indicating the importance of social affiliation for females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Hairin Kim, Seyul Kwak, Elisa C. Baek, Naeun Oh, Ekaterina Baldina, Yoosik Youm, Jeanyung Chey
Summary: Social exclusion occurs in various social relationships, and the role of these relationships in social exclusion is not well understood. This study investigated how pre-existing social relationships with rejecters influenced the brain response of individuals experiencing social exclusion. The findings suggest that the level of distress during social exclusion is related to the lack of closeness within a triad, and this sparsity can be predicted by functional connectivity in brain regions implicated in social pain and mentalizing during Cyberball.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Talat Bulut
Summary: This study used a meta-analytic connectivity modeling approach to investigate the language-related functional connectivity patterns of the left and right inferior frontal gyrus (IFG) subdivisions. The results showed a primarily left-lateralized functional network and highlighted the importance of the opercular part of the left IFG in the language network.
Review
Neurosciences
Corey Horien, Dorothea L. Floris, Abigail S. Greene, Stephanie Noble, Max Rolison, Link Tejavibulya, David O'Connor, James C. McPartland, Dustin Scheinost, Katarzyna Chawarska, Evelyn M. R. Lake, R. Todd Constable
Summary: This article reviews the use of predictive modeling in understanding autism through measures of functional connectivity and symptoms, and discusses how different frameworks can improve our understanding of the neural basis of complex symptoms. The article highlights the need to consider factors such as data decay and sampling biases in study interpretation, and suggests exciting future directions for predictive modeling in autism.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Fengmei Fan, Shuping Tan, Junchao Huang, Song Chen, Hongzhen Fan, Zhiren Wang, Chiang-Shan R. Li, Yunlong Tan
Summary: This study found that patients with schizophrenia exhibit deficits in functional connectivity within the default mode network subsystems. These deficits are present in both early-stage and recurrent patients, suggesting that they may be trait-like characteristics. The findings suggest that these connectivity deficits may be useful for early diagnosis, and that dysfunction in the medial temporal lobe may play a crucial role in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Behavioral Sciences
Gert Vanhollebeke, Fiebe Aers, Lauren Goethals, Rudi De Raedt, Chris Baeken, Pieter van Mierlo, Marie-Anne Vanderhasselt
Summary: This study systematically reviewed the Cyberball-ERP literature and evaluated the effects of social exclusion and paradigm characteristics on ERP changes, finding that expectancy violations better explain the results of the P3 complex.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Fengmei Fan, Zhiren Wang, Hongzhen Fan, Jing Shi, Hua Guo, Fude Yang, Shuping Tan, Yunlong Tan
Summary: This study found that patients with bipolar disorder have reduced functional connectivity between the core subsystem and the medial temporal lobe subsystem, especially during depressive episodes. The strength of this connection is negatively correlated with depression symptoms. This study reveals the neuropathological mechanism of bipolar disorder from the perspective of brain functional connectivity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Michihiro Kaneko, Yoshiyuki Ueda
Summary: Social exclusion affects individuals' basic needs, and their coping behavior is influenced by their dispositional need to belong. Eating can be one such behavior. However, it is unclear how individuals with higher or lower dispositional need to belong respond in terms of food consumption after social exclusion. This study aimed to investigate which group, higher or lower need to belong, consumes more food after social exclusion. The results showed that individuals with a lower need to belong increased their consumption when socially excluded, while those with a higher need to belong did not.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemical Research Methods
Bo Zhou, Xuejiao Dou, Wei Wang, Hongxiang Yao, Feng Feng, Pan Wang, Zhengyi Yang, Ningyu An, Bing Liu, Xi Zhang, Yong Liu
Summary: This study found abnormalities in the connectivity of the default mode network in patients with aMCI and AD, and these abnormalities were correlated with the cognitive abilities of the patients. There was also structural-functional decoupling between certain components of the network.
Article
Neurosciences
Yin Wang, Athanasia Metoki, Yunman Xia, Yinyin Zang, Yong He, Ingrid R. Olson
Summary: This study reveals the brain-wide organization and mechanisms of mentalizing processing, showing the detailed connectomic features of the mentalizing network. It demonstrates that mentalizing unfolds across functionally heterogeneous regions with highly structured fiber tracts and unique hierarchical functional architecture, distinguishing it from other brain networks supporting related functions such as autobiographical memory and moral reasoning.
Article
Neuroimaging
Nandita C. Vijayakumar, Theresa W. Cheng, Jessica E. Flannery, John C. A. Flournoy, Garrett H. Ross, Arian Mobasser, Zdena Op de Macks, Philip A. Fisher, Jennifer H. Pfeifer
Summary: This study investigated neural responses to exclusionary and inclusionary peer interactions in adolescents in foster care. The findings suggest that adolescents in foster care exhibit greater neural sensitivity to exclusion and reduced sensitivity to inclusion compared to a community sample.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Chris Zajner, Nathan R. Spreng, Danilo Bzdok
Summary: Elaborate social interaction is an important asset for the human species, and the complexity of people's social lives plays a significant role in their environment. This study focuses on the relationship between the allocortical hippocampus (HC) and the neocortical default network (DN) in the context of social isolation. The findings suggest that the lack of social support is associated with specific subregions in the DN patterns, and these patterns are linked to HC subfields such as subiculum, presubiculum, CA2, CA3, and dentate gyrus.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Roni Setton, Signy Sheldon, Gary R. Turner, R. Nathan Spreng
Summary: Recollection of personal past events differs across the lifespan, with older individuals recalling fewer episodic details and conveying more semantic information than young. This study examines the relationship between gray matter volumes in temporal lobe regions (hippocampus and temporal poles) and age differences in autobiographical recollection. The findings show that older adults have smaller gray matter volumes in the posterior hippocampus and display less episodic and more semantic autobiographical memory compared to younger adults. Age-related associations between temporal pole volumes and episodic autobiographical recall were also observed in older adults, while in younger adults, temporal pole volume was correlated with performance on standard laboratory measures of semantic memory. Exploratory analyses further revealed that the relationship between age-related episodic autobiographical memory and anterior hippocampal volumes was dependent on sex. These findings suggest that age differences in brain structures implicated in episodic and semantic memory may indicate neural circuit reorganization to support autobiographical memory in later life.
Article
Geriatrics & Gerontology
Karin Kantarovich, Laetitia Mwilambwe-Tshilobo, Sara Fernandez-Cabello, Roni Setton, Giulia Baracchini, Amber W. Lockrow, R. Nathan Spreng, Gary R. Turner
Summary: White matter hyperintensities (WMH) in older adults are associated with changes in the functional connectome and lower fluid intelligence.
NEUROBIOLOGY OF AGING
(2022)
Article
Multidisciplinary Sciences
R. Nathan Spreng, Roni Setton, Udi Alter, Benjamin N. Cassidy, Bri Darboh, Elizabeth DuPre, Karin Kantarovich, Amber W. Lockrow, Laetitia Mwilambwe-Tshilobo, Wen-Ming Luh, Prantik Kundu, Gary R. Turner
Summary: This article provides two 10-minute multi-echo functional MRI (ME-fMRI) runs and structural MRI (T1-MPRAGE) data, as well as a large amount of behavioral assessment data, including cognition, personality, and socioemotional functioning. These data are valuable for scientists studying BOLD signal, brain-behavior associations, and aging effects in healthy adults.
Article
Biology
Zhen-Qi Liu, Bertha Vazquez-Rodriguez, R. Nathan Spreng, Boris C. Bernhardt, Richard F. Betzel, Bratislav Misic
Summary: The study revealed that the coupling between structure and function in the human brain is regionally heterogeneous, with dynamic structure-function coupling patterns being region-specific. This provides a new perspective to study structure-function relationships and highlights the importance of considering regional differences in brain connectivity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Roni Setton, Laetitia Mwilambwe-Tshilobo, Signy Sheldon, Gary R. Turner, R. Nathan Spreng
Summary: Recollection of personal past, or autobiographical memory (AM), varies across individuals and the life span, and is associated with functional brain networks. Older adults showed lower connectivity within certain brain regions but greater connectivity with the default network compared to younger adults. The connectivity patterns were related to specific types of memories.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jixing Li, Shohini Bhattasali, Shulin Zhang, Berta Franzluebbers, Wen-Ming Luh, R. Nathan Spreng, Jonathan R. Brennan, Yiming Yang, Christophe Pallier, John Hale
Summary: This study presents the Le Petit Prince fMRI Corpus (LPPC-fMRI), a multilingual resource for cognitive neuroscience research on speech and language. The corpus includes fMRI data of English, Chinese, and French speakers listening to the same audiobook, as well as time-aligned speech annotations and word-by-word predictors. The dataset is of high quality and can facilitate cross-linguistic comparisons in language processing.
Article
Neurosciences
Laetitia Mwilambwe-Tshilobo, Roni Setton, Danilo Bzdok, Gary R. R. Turner, R. Nathan Spreng
Summary: This study investigates the impact of age on the functional connectivity associated with loneliness and empathic responding using neuroimaging techniques. The results show that there are age-related differences in the functional connectivity of loneliness and empathic responding, suggesting that age may influence social and cognitive functions in the brain. The findings suggest that loneliness is associated with the integration of visual and association networks in younger adults, while empathic responding is associated with the integration of visual and association networks in both age groups. These results highlight the involvement of different neurocognitive processes in social experiences across the lifespan of humans.
NETWORK NEUROSCIENCE
(2023)
Review
Health Care Sciences & Services
Catherine Paquet, Jocelyne Whitehead, Rishabh Shah, Alayne Mary Adams, Damion Dooley, R. Nathan Spreng, Anna-Liisa Aunio, Laurette Dube
Summary: Social prescription programs aim to link primary care patients with community resources to improve their well-being. This study integrates scientific evidence with on-the-ground knowledge to develop an extensive list of intervention terms and keywords related to reducing social isolation and loneliness in older adults. The findings highlight effective intervention types and the need for efficient identification and structuring of resources to facilitate referrals for older adults.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Clinical
Tobias Janelt, Tobias Altmann, R. Nathan Spreng, Marcus Roth
Summary: The study aimed to validate the German version of the TEQ and contribute empirical evidence to the debate on its singular versus multidimensional factor structure. The results showed that TEQ has a unidimensional factor structure and demonstrated sufficient internal consistency, test-retest reliability, one-year stability, as well as convergent and discriminant validity with measures of empathy, emotion recognition, emotion regulation, altruism, social desirability, and the Big Five personality traits.
JOURNAL OF PERSONALITY ASSESSMENT
(2023)
Article
Clinical Neurology
Alfie Wearn, Lars Lau Raket, D. Louis Collins, R. Nathan Spreng
Summary: Early detection of Alzheimer's disease is crucial for preventive treatment strategies. Texture analysis of the hippocampus can detect microstructural changes before cognitive impairment occurs, providing additional information beyond hippocampal volume for predicting future cognitive decline.
BRAIN COMMUNICATIONS
(2023)
Article
Psychology, Mathematical
Amber W. W. Lockrow, Roni Setton, Karen A. P. Spreng, Signy Sheldon, Gary R. R. Turner, R. Nathan Spreng
Summary: Autobiographical Interview (AI) is a performance-based assessment that quantifies the episodic and semantic features of recalled and verbally conveyed prior experiences. This study investigated the reliability, validity, association to individual differences measures, and factor structure of the AI in healthy younger and older adults. The AI demonstrated strong reliability, validity, and a two-factor structure, and showed correlations with standard measures of episodic memory.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Psychology, Mathematical
Roni Setton, Amber W. Lockrow, Gary R. Turner, R. Nathan Spreng
Summary: The SAM showed reliability as a self-report measure of perceived recollective capacity, but weak associations with actual memory performance and age effects were observed. It was significantly associated with self-efficacy, suggesting confidence in general self-report abilities. Caution is advised in using and interpreting the SAM as a measure of autobiographical memory, pending further validation and revision.
BEHAVIOR RESEARCH METHODS
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
