Comprehensive characterization of protein–protein interactions perturbed by disease mutations

Pan-cancer analysis of whole genomes

(2020)   NATURE

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

(2019) Rocio G Urdinguio et al.   NUCLEIC ACIDS RESEARCH

Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program

(2019) Chloé Sarnowski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Systematic Functional Annotation of Somatic Mutations in Cancer

(2018) Patrick Kwok-Shing Ng et al.   CANCER CELL

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Development of encorafenib for BRAF-mutated advanced melanoma

(2018) Peter Koelblinger et al.   CURRENT OPINION IN ONCOLOGY

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders

(2018) Siwei Chen et al.   NATURE GENETICS

Interactome INSIDER: a structural interactome browser for genomic studies

(2018) Michael J Meyer et al.   NATURE METHODS

Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health

(2018) Feixiong Cheng et al.   PHARMACOLOGICAL REVIEWS

Novel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy

(2018) Melissa M. Blessing et al.   Acta Neuropathologica Communications

The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies

(2017) Peter D. Stenson et al.   HUMAN GENETICS

Nine paths to PCSK9 inhibition

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

(2017) Angela M Halstead et al.   eLife

Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure

(2016) Collin Tokheim et al.   CANCER RESEARCH

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Protein-structure-guided discovery of functional mutations across 19 cancer types

(2016) Beifang Niu et al.   NATURE GENETICS

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Control of the negative IREStrans-acting factor KHSRP by ubiquitination

(2016) Yu-An Kung et al.   NUCLEIC ACIDS RESEARCH

Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway

(2016) Weiliang Lu et al.   TUMOR BIOLOGY

Variegated RHOA mutations in adult T-cell leukemia/lymphoma

(2015) Y. Nagata et al.   BLOOD

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

(2015) Nidhi Sahni et al.   CELL

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

Giant study poses DNA data-sharing dilemma

(2015) Sara Reardon   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

dSysMap: exploring the edgetic role of disease mutations

(2015) Roberto Mosca et al.   NATURE METHODS

Database resources of the National Center for Biotechnology Information

(2015)   NUCLEIC ACIDS RESEARCH

Comprehensive assessment of cancer missense mutation clustering in protein structures

(2015) Atanas Kamburov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

(2015) Eduard Porta-Pardo et al.   PLoS Computational Biology

ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers

(2014) B. G. Pierce et al.   BIOINFORMATICS

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells

(2014) LEI LIANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TCGA-Assembler: open-source software for retrieving and processing TCGA data

(2014) Yitan Zhu et al.   NATURE METHODS

Histone H3.3 Mutations: A Variant Path to Cancer

(2013) Benjamin T.K. Yuen et al.   CANCER CELL

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

(2013) Gai Yan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

(2013) Hongtai Zhang et al.   NATURE GENETICS

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Interactome3D: adding structural details to protein networks

(2012) Roberto Mosca et al.   NATURE METHODS

Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis

(2011) M. Zillhardt et al.   CLINICAL CANCER RESEARCH

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

(2008) Shilpa Pandit et al.   JOURNAL OF LIPID RESEARCH

5-Lipoxygenase: mechanisms of regulation

(2008) Olof Rådmark et al.   JOURNAL OF LIPID RESEARCH