Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Review
Chemistry, Multidisciplinary
Xi Li, Yabing Zhang, Xiangyi Ren, Yan Wang, Dongxu Chen, Qian Li, Minfeng Huo, Jianlin Shi
Summary: Advancements in nanoscience and nanotechnology offer a new opportunity for delivering drugs for treating ischemia-related diseases effectively, while intelligent biomaterials have been developed to enhance the therapeutic benefits of drugs for treating myocardial ischemia.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Qi Jiang, Shufang Zhang
Summary: Osteoarthritis (OA) is a common age-related degenerative disease that poses economic and societal burdens, especially with the increasing aging population. Stimulus-responsive nanoplatforms offer improved therapeutic strategies for OA, with potential benefits such as enhanced control, longer retention time, higher loading rates, and increased sensitivity. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms, categorized by endogenous and exogenous stimuli, and discusses the opportunities, restrictions, and limitations of these systems.
Article
Engineering, Biomedical
Mohammad Souri, M. Soltani, Farshad Moradi Kashkooli, Mohammad Kiani Shahvandi, Mohsen Chiani, Fatemeh Sadat Shariati, Mohammad Reza Mehrabi, Lance L. Munn
Summary: Nanotechnology has shown promising results in medical applications, particularly in oncology as drug delivery systems. However, the clinical translation of this technology is challenging. To optimize drug delivery systems for clinical translation, the physicochemical characteristics of nanoparticles can be specified. Researchers have focused on producing biocompatible materials, production technologies, or new formulations to improve efficiency and stability. The effects of design parameters can be studied using various methods. This review summarizes the advances and technologies in cancer nanomedicines for clinical translation and commercialization, as well as the existing challenges and opportunities in the field.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Pratikshya Sa, Sanjeeb K. Sahoo, Fahima Dilnawaz
Summary: Cancer is a major global health challenge, and the tumor microenvironment plays a vital role in tumor progression and drug resistance. Targeting the tumor microenvironment is a promising approach to advance cancer nanomedicine. Recent progress in understanding the tumor microenvironment and developing responsive nanoparticles has improved pharmacokinetics and efficacy of nanomedicine in overcoming drug resistance. This review discusses the components of the tumor microenvironment and the role of nanomedicine in combating drug resistance.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Yanhong Liu, Linjiao Chen, Qingyang Shi, Qing Zhao, Hongshuang Ma
Summary: Tumor microenvironment-responsive polypeptide nanogels have excellent biocompatibility and degradability, and can be used for selective delivery of antitumor drugs. These nanogels can release drugs in response to stimuli from tumor tissues or cells, reducing side effects and improving efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yanfang Wang, Pengbo Chen, Wei Liu, Xiangqian Wei, Juan Zhang, Xinwei Wei, Yun Liu, Luxuan Rao, Shiming Zhang, Jicheng Yu, Xiao Ye, Jinqiang Wang, Zhen Gu
Summary: Researchers have developed a novel insulin nanocarrier system that can effectively and safely control blood glucose levels in type 1 diabetes patients for an extended period of time.
Article
Multidisciplinary Sciences
Sarah J. Shepherd, Xuexiang Han, Alvin J. Mukalel, Rakan El-Mayta, Ajay S. Thatte, Jingyu Wu, Marshall S. Padilla, Mohamad-Gabriel Alameh, Neha Srikumar, Daeyeon Lee, Drew Weissman, David Issadore, Michael J. Mitchell
Summary: Lipid nanoparticles (LNPs) are an important delivery technology that has achieved significant breakthroughs in mRNA therapeutics and vaccines. Researchers have developed a microfluidic chip to address the challenges in LNP production, achieving scalable production rates while maintaining the physical properties and efficacy of LNPs. The vaccines formulated using this chip have shown promising results in preclinical studies, demonstrating the feasibility of commercial production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Anais Brion, Juliane Chaud, Jeremie Leonard, Frederic Bolze, Stefan Chassaing, Benoit Frisch, Beatrice Heurtault, Antoine Kichler, Alexandre Specht
Summary: Photolytic reactions using photolabile protecting groups allow the optical control of liberating biological effectors. This study presents light-sensitive lipid nanocapsules that can release an antitumoral drug through photolysis. The use of original photon upconverting nanoparticles chemically conjugated to a coumarin-based photocleavable linker enables the release of the drug through upconversion luminescence-assisted photolysis using deep-red excitation. These findings have implications for future therapeutic applications in nanomedicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Review
Biotechnology & Applied Microbiology
Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato, Jun Wu
Summary: The rapid development of nanomedicine and nanoparticle materials has the potential to revolutionize healthcare by improving the effectiveness, bioavailability, targeting, and safety of drugs. Nanoparticles have unique properties that make them ideal for medical applications, but they must overcome biological barriers to deliver drugs to specific locations. Biointerface engineering can help overcome these barriers and optimize drug delivery in a personalized manner.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Oncology
Yifei Xia, Shao Duan, Chaozhe Han, Chengwei Jing, Zunyu Xiao, Chao Li
Summary: This review provides a comprehensive overview of the latest progress in novel stimuli-responsive nanomaterials targeting the hypoxia-tumor microenvironment in cancer diagnosis and therapy. The future prospects and challenges of nanomaterials are also discussed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Sauradip Chaudhuri, Martha J. Fowler, Cassandra Baker, Sylwia A. Stopka, Michael S. Regan, Lindsey Sablatura, Colton W. Broughton, Brandon E. Knight, Sarah E. Stabenfeldt, Nathalie Y. R. Agar, Rachael W. Sirianni
Summary: This research introduces a novel nanocarrier platform for encapsulating HDACi, improving drug delivery efficiency, and providing insights into the structural requirements for effective drug loading and self-assembly of nanoparticles. The optimized CDN nanoparticles show promising results in slowing tumor growth and increasing exposure of tumors to drugs, indicating a step forward in HDACi therapy for better disease treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Xi He, Bei Xu, Aiping Fang, Xuan Li, Zhiying Huang, Shugang Qin, Wen Xiao, Guohong Li, Miaomiao Tian, Na Fan, Xiangrong Song
Summary: Most nanomedicines can reduce the side effects of anti-tumor chemical drugs but have limited therapeutic efficacy due to sustained drug release. A cascade-responsive nanoplatform with burst release of chemotherapeutics based on tumor cell targeting delivery could be a promising alternative strategy.
ACTA BIOMATERIALIA
(2023)
Review
Biotechnology & Applied Microbiology
Yabin Wang, Wenzhen Wang, Fangong Kong, Qiu Zhang, Jiaqi Xiao, Yi Zhang, Bing Yan
Summary: Exosomes, lipid bilayer vesicles released from cells for intracellular communication, show potential in disease diagnosis and drug delivery. However, challenges like purification and detection technologies remain, prompting the use of nanotechnology for advancement. Studies on utilizing nanoparticles to enhance exosome properties are mostly at the laboratory stage, with translation to clinical applications still a long way off.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Can Liu, Qiu Peng, Lingyu Wei, Zhengshuo Li, Xiaoyue Zhang, Yangge Wu, Jia Wang, Xiang Zheng, Yuqing Wen, Run Zheng, Qun Yan, Qiurong Ye, Jian Ma
Summary: Lactoferrin has anti-inflammatory effects in acute inflammation by suppressing macrophage chemotaxis through inhibiting the expression of macrophage-associated chemokines Ccl2 and Ccl5. This offers a potential treatment for acute inflammatory diseases.
Review
Cell Biology
Lin Zhao, Yuanyuan Liu, Simiao Zhang, Lingyu Wei, Hongbing Cheng, Jinsheng Wang, Jia Wang
Summary: Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells. Reprogrammed energy metabolism affects the development of tumor suppressive immune microenvironment and the progression of gastric cancer (GC). The tumor microenvironment (TME) has important clinical and pathological significance in predicting prognosis and therapeutic efficacy. Understanding the targeted metabolism of metabolic reprogramming can enhance anti-tumor immune responses and provide direction for the treatment and prognosis of GC.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Yang Liu, Zhongyu Jiang, Shizheng Tong, Yifu Sun, Yu Zhang, Jiayuan Zhang, Duoyi Zhao, Yuanzhen Su, Jianxun Ding, Xuesi Chen
Summary: Biomineralization is a normal physiological process involving nucleation, crystal growth, phase transformation, and orientation evolution. Inducing biomineralization in tumor tissue has shown promise as a therapy for malignancy. However, the limited ion-chelating capabilities of carboxyl-containing biomineralization initiators have hindered their efficacy. In this study, a biomineralization-inducing nanoparticle (BINP) was developed for blockade therapy of osteosarcoma. BINP exhibited tumor inhibition rates of 59.3% and 52.1% for subcutaneous and orthotopic osteosarcomas, respectively. The BINP-mediated blockade therapy also inhibited bone dissolution and pulmonary metastases. This selective biomineralization approach holds promise for clinical osteosarcoma therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qihui Wang, Jiayi Luan, Zhilong Zhao, Weihui Kong, Congxiao Zhang, Jianxun Ding
Summary: Dentin hypersensitivity (DH) is a common cause of toothache with rapid onset and short duration. Current clinical treatment strategies have limitations, leading to long-term administration, poor dentinal tubule closure, and the development of secondary caries. Various biomaterials have been developed to improve the treatment efficiency of DH by participating in dental remineralization. This review discusses the application of biomaterials for DH therapy based on different desensitization mechanisms and presents a perspective on the future of dentin regeneration medicine for DH therapy.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Xukai Wang, Mingran Zhang, Tongtong Zhu, Qiuhua Wei, Guangyao Liu, Jianxun Ding
Summary: Osteomyelitis is a refractory disease in orthopedics caused by infection with pathogenic microorganisms. Antibacterial therapy, in addition to surgical debridement, is currently the main approach for treating osteomyelitis. However, traditional antibiotics are facing bacterial resistance, prompting the development of advanced antibacterial agents. This review discusses the main targets and mechanisms of antibacterial agents for osteomyelitis treatment, as well as their potential clinical applications.
Editorial Material
Pharmacology & Pharmacy
Zongtai Liu, Jin Zhang, Changfeng Fu, Jianxun Ding
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Physical
Shunyi Lu, Wen Chen, Jiayi Wang, Zilong Guo, Lan Xiao, Lingyu Wei, Jieqin Yu, Ya Yuan, Weisin Chen, Mengxuan Bian, Lei Huang, Yuanyuan Liu, Jian Zhang, Yu-Lin Li, Li-Bo Jiang
Summary: A biodegradable, conductive poly(l-lactide-co-caprolactone)/graphene (PLCL/GN) composite conduit with a micropatterned surface and electrical stimulation capability is developed. It effectively stimulates cell migration, adhesion, and elongation, enhances neuronal expression of SCs, and promotes myelin sheath growth and nerve regeneration in vivo.
Article
Chemistry, Multidisciplinary
Jiazhen Yang, Hongjie Li, Haoyang Zou, Jianxun Ding
Summary: Intoxication is a common cause of accidental death worldwide. Although some antidotes have been developed, clinicians mainly rely on nonspecific extracorporeal techniques for removing toxins. Nano-intervention strategies using nanoantidotes to neutralize toxicity in situ have shown clinical potential. However, most nanoantidotes are still in the proof-of-concept stage, and challenges such as constructing clinical relevance models and understanding their pharmacokinetics hinder their translation to the clinic. This Concept reviews the detoxification mechanisms of polymer nanoantidotes and discusses the opportunities and challenges of their clinical application.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Physical
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding
Summary: The immune system plays a vital role in the occurrence and development of cancer. Immunotherapy offers a promising approach to treat and cure cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells activates innate and adaptive immune responses by releasing tumor-associated antigens and damage-associated molecular patterns. This review summarizes the progress in using biomaterials to induce ICD and discusses their potential application in cancer immunotherapy.
Review
Chemistry, Multidisciplinary
Ke Yi, Huimin Kong, Yeh-Hsing Lao, Di Li, Rachel L. Mintz, Tianxu Fang, Guojun Chen, Yu Tao, Mingqiang Li, Jianxun Ding
Summary: CRISPR/Cas9 gene-editing technology has great potential in cancer treatment, but limitations of viral delivery have led to the development of non-viral nanomaterials. Optimizing the packaging capacity, pharmacokinetics, and targetability of non-viral CRISPR/Cas9 nanoformulations can enhance the safety and efficacy of cancer therapy.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Qiang Luo, Wei Sun, Zhibo Li, Jinfeng Sun, Yu Xiao, Jichang Zhang, Cuilin Zhu, Bin Liu, Jianxun Ding
Summary: Although reperfusion therapy is commonly used for the treatment of acute myocardial infarction, its efficacy is limited by the occurrence of myocardial ischemia-reperfusion injury (MIRI). Systemic drug administration to reduce MIRI is often ineffective. Therefore, the development of functional biomaterials to improve drug targetability and bioavailability, and reduce side effects, is of great importance.
Article
Chemistry, Multidisciplinary
Guanqing Yang, Yang Liu, Jinjin Chen, Jianxun Ding, Xuesi Chen
Summary: Cancer is a disease characterized by uncontrolled growth and division of abnormal cells. However, the clinical application of therapeutic agents is hindered by low tumor specificity and high toxicity to healthy tissues. Self-adaptive nanomaterials, which undergo transformation in response to specific stimuli, have the potential to overcome these limitations and improve the efficacy of cancer therapy.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Review
Materials Science, Biomaterials
Jinjin Chen, Jiazhen Yang, Jianxun Ding
Summary: This review summarizes the development of Cys(2)-based polypeptide nanoparticles and their unique properties and multifunctional applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Meeting Abstract
Developmental Biology
Julian A. Henao-Restrepo, Lingyu Wei, Jose M. Murrieta-Coxca, Paulina Fuentes-Zacarias, Tanja Groten, Udo R. Markert, Diana M. Morales-Prieto
Article
Engineering, Environmental
Yujie Zhao, Xuetao Liang, Hongyu Dou, Haidi Zhang, Miao Zhang, Lingyu Wei, Yanxiang Li, Qi Yang
Summary: The study introduced a novel heterojunction photocatalytic material Bi4O5Br2/Bi2S3 with oxygen vacancies (OVs), exhibiting outstanding photocatalytic activity for Cr (VI) reduction. The optimal composite Bi4O5Br2/Bi2S3-2 reduced 91.3% of Cr (VI) under neutral conditions and maintained over 70% efficiency in stability tests. The high efficiency was attributed to excellent light-trapping ability and efficient carrier migration and separation through a Z-scheme structure containing OVs.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
