Review
Chemistry, Multidisciplinary
Chendi Ding, Chunbo Chen, Xiaowei Zeng, Hongzhong Chen, Yanli Zhao
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Review
Chemistry, Physical
Bingyang Chu, Hanzhi Deng, Ting Niu, Ying Qu, Zhiyong Qian
Summary: This review comprehensively summarizes the latest research advances in stimulus-responsive CPT nano-prodrugs, including preparation strategies, responsive release mechanisms, and their applications in cancer therapy. Special focus is placed on the release mechanisms and characteristics of various stimulus-responsive CPT nano-prodrugs and their application in cancer treatment. Furthermore, clinical applications of CPT prodrugs are discussed. Finally, challenges and future research directions for CPT nano-prodrugs are discussed.
Review
Chemistry, Multidisciplinary
Dengshuai Wei, Yong Sun, Hu Zhu, Qinrui Fu
Summary: Stimuli-responsive polymers have been widely used in biomedical applications due to their ability to respond to internal and external stimuli. In the context of the tumor microenvironment, these polymers are used to prepare smart nanovehicles for targeted drug delivery. TME-responsive nanosystems offer many advantages over conventional drug delivery systems, leading to significant advances in cancer diagnosis and therapy.
Article
Nanoscience & Nanotechnology
Junmei Zhang, Yuanyuan Zhang, Bingbing Zhao, Mengtong Lv, Enping Chen, Changshun Zhao, Linyang Jiang, Hongliang Qian, Dechun Huang, Yinan Zhong, Wei Chen
Summary: The study developed a cascade-responsive hierarchical nanosystem for spatially programed delivery of multiple drugs and simultaneously overcoming biological pathway barriers by releasing alpha PD-L1 and PTX in the tumor microenvironment, achieving enhanced chemoimmunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Xue-Yan Yang, Bo Yuan, Hai Xiong, Yahao Zhao, Lu Wang, San-Qi Zhang, Shuai Mao
Summary: In this study, a series of novel H2O2-activated theranostic prodrugs were developed with improved stability and selectivity. By selectively activating fluorescence signals, these prodrugs can be used for real-time monitoring of drug release and H2O2 generation, which holds potential applications in tumor therapy.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng, Changmei Zhang
Summary: A novel tumor-targeted nanosupramolecular prodrug was designed and fabricated via a disulfide bond, with an optimal glycosylated ligand selected for higher drug loading compared to traditional nanoparticles. Among different glycoligands, maltose modified nanosupramolecular prodrug exhibited the strongest anti-tumor effects.
Article
Pharmacology & Pharmacy
Chen Fu, Jingcan Qin, Xinlong Liu, Fei Kong
Summary: In this study, galactose decorated trimethyl chitosan-camptothecin nanoparticles were successfully prepared, and it was found that the nanoparticles exhibited efficient drug release under high GSH concentration, resulting in enhanced antitumor effect and reduced systemic toxicity. This study provides potential for targeted chemotherapy in hepatocellular carcinoma.
Review
Pharmacology & Pharmacy
Pedro Cruz-Nova, Alejandra Ancira-Cortez, Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Brenda Gibbens-Bandala
Summary: Nanoparticles have great potential in cancer treatment, as they can be combined with different molecules to improve therapeutic efficacy and reduce side effects. They can be used to enhance chemotherapy and radiation therapy, increase blood circulation time, and improve treatment outcomes through targeted delivery. Additionally, radiolabeled nanoparticles can be used for diagnosis, drug delivery, and photothermal therapy.
Article
Pharmacology & Pharmacy
Yanhao Zhang, Ji Wang, Hanlei Xing, Chao Liu, Xinsong Li
Summary: In this study, a redox-responsive paclitaxel-pentadecanoic acid prodrug conjugate embedded human serum albumin nanoparticles (HPTX NPs) were developed for cancer chemotherapy. The HPTX NPs exhibited high drug loading, longer drug retention, more effective tumor growth inhibition, and lower systemic toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Xi Tan, Hong Zhou, Chenhui Wang, Xuhan Liu, Xiangliang Yang, Wei Liu
Summary: Combination chemo-immunotherapy is a promising strategy for enhanced anti-tumor effects with reduced side effects. In this study, the researchers designed a novel glutathione-responsive camptothecin-based hybrid micellar nanoparticles, which achieved synergistic antitumor chemoimmunotherapy by knocking down PD-L1. The nanoparticles showed high loading efficiency, responsive drug release, and excellent stability and biosafety. The study demonstrated the potential of designing co-delivery nanoparticles for antitumor chemo-immunotherapy.
Article
Chemistry, Physical
Xi Tan, Hong Zhou, Chenhui Wang, Xuhan Liu, Xiangliang Yang, Wei Liu
Summary: Combinational chemo-immunotherapy using RNA interference (RNAi) to target PD-L1 has been developed to enhance antitumor immune response. A GSH-responsive camptothecin prodrug-based micellar nanoparticle was designed for the co-delivery of siPD-L1 and CPT, showing high loading efficiency and controlled drug release. This study provides a perspective on the design of co-delivery nanoparticles for antitumor chemo-immunotherapy.
Article
Pharmacology & Pharmacy
Partha Laskar, Anupam Dhasmana, Sudhir Kotnala, Meena Jaggi, Murali M. M. Yallapu, Subhash C. C. Chauhan
Summary: In cancer combination therapy, a PEGylated dual drug, conjugated amphiphilic polymer (CPT-S-S-PEG-CUR), has been synthesized to improve the delivery of multiple anti-cancer hydrophobic drugs. These self-assembled nano-assemblies exhibit a preferential release of one of the drugs in a tumor-relevant redox environment, leading to enhanced antiproliferative effect in cancer cells. This redox-responsive, dual-drug conjugated, FRET pair-based nanosized delivery vector shows promise as an advanced theranostic system for effective cancer treatment.
Article
Nanoscience & Nanotechnology
Zhang Ye, Lun Gao, Jiayang Cai, Yixuan Wang, Yong Li, Shiao Tong, Tengfeng Yan, Qian Sun, Yangzhi Qi, Yang Xu, Hongxiang Jiang, Si Zhang, Linyao Zhao, Shenqi Zhang, Qianxue Chen
Summary: Glioblastoma multiforme (GBM) is the most debilitating and fatal intracranial malignancy. Nanotechnology shows potential in overcoming chemotherapy resistance caused by the blood-brain barrier (BBB). Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible polymer widely used in the pharmaceutical industry. The size of PLGA nanoparticles (NPs) plays a crucial role in their ability to penetrate the BBB. Researchers have developed a prodrug that responds to the GBM microenvironment and combined it with nanoparticles to overcome the BBB, leading to inhibited tumor growth and prolonged survival in mice.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Zhiling Song, Kechen Song, Yi Xiao, Hui Guo, Yizhun Zhu, Xiaolin Wang
Summary: This review discusses recent advances in smart nanosystems for cardiovascular diseases, highlighting their responsive capabilities to various biological cues and their potential applications in drug delivery and disease monitoring.
CURRENT DRUG DELIVERY
(2021)
Article
Chemistry, Medicinal
Ruiming Zhang, Yi Luo, Chenghao Du, Ling Wu, Yankang Wang, Yuanduan Chen, Shouqian Li, Xin Jiang, Yongmei Xie
Summary: A novel SN38-glucose conjugate (FSY04) was synthesized to improve the water solubility and bioavailability of SN38. In vitro studies showed that FSY04 had stronger inhibitory effects on colorectal cancer cell lines compared to CPT-11, with lower cytotoxicity against normal cells. FSY04 also showed superior activity in inducing apoptosis, inhibiting migration, and invasion. In vivo experiments demonstrated that FSY04 had better tumor growth inhibition in a xenograft tumor model compared to CPT-11. These findings suggest that FSY04 is a promising agent for CRC therapy.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
