Metaoptronic Multiplexed Interface for Probing Bioentity Behaviors

Biointerface sensors have brought about remarkable advances in modern biomedicine. To accurately monitor bioentity's behaviors, biointerface sensors need to capture three main types of information, which are the electric, spectroscopic, and morphologic signals. Simultaneously obtaining these three types of information is of critical importance in the development of future biosensor, which is still not possible in the existing biosensors. Herein, by synergizing metamaterials, optical, and electronic sensing designs, we proposed the metaoptronic multiplexed interface (MMI) and built a MMI biosensor which can collectively record electric, spectroscopic, and morphologic information on bioentities. The MMI biosensor enables the real-time triple-monitoring of cellular dynamics and opens up the possibility for powerlessly monitoring ocular dryness. Our findings not only demonstrate an advanced multiplexed biointerface sensor with integrated capacities but also help to identify a uniquely significant arena for the nanomaterials, meta-optics, and nanotechnologies to play their roles in a complementary manner.

Automated summary

Biointerface sensors have made significant advances in modern biomedicine by accurately monitoring bioentity behaviors through capturing electric, spectroscopic, and morphologic signals. The metaoptronic multiplexed interface (MMI) biosensor enables real-time triple-monitoring of bioentities, opening up new possibilities for future biosensor development. This advanced multiplexed biointerface sensor not only demonstrates integrated capacities but also highlights a significant arena for nanomaterials, meta-optics, and nanotechnologies to play complementary roles.