T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells

The molecular basis underpinning the potency and specificity of MAIT cell antigens

(2020) Wael Awad et al.   NATURE IMMUNOLOGY

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

(2020) Michael D. Crowther et al.   NATURE IMMUNOLOGY

Ligand-dependent downregulation of MR1 cell surface expression

(2020) Mariolina Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MAIT TCRβ chain contributes to discrimination of microbial ligand

(2020) Gitanjali A Narayanan et al.   IMMUNOLOGY AND CELL BIOLOGY

MAIT Cell Development and Functions: the Microbial Connection

(2020) François Legoux et al.   IMMUNITY

Atypical TRAV1-2− T cell receptor recognition of the antigen-presenting molecule MR1

(2020) Wael Awad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biology and functional importance of MAIT cells

(2019) Dale I. Godfrey et al.   NATURE IMMUNOLOGY

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

(2019) François Legoux et al.   SCIENCE

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

(2019) Tianqi Leng et al.   Cell Reports

Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease

(2018) Joannie M. Allaire et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ontogeny of human mucosal-associated invariant T cells and related T cell subsets

(2018) Ghada Ben Youssef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

(2018) Lauren J. Howson et al.   Nature Communications

The Conventional Nature of Non-MHC-Restricted T Cells

(2018) Marco Lepore et al.   Frontiers in Immunology

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

(2016) Nicholas A. Gherardin et al.   IMMUNITY

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

(2016) Erin W. Meermeier et al.   Nature Communications

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

(2015) Prabhat K. Sharma et al.   IMMUNOLOGY

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

(2014) Marielle C. Gold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins

(2013) J. Lopez-Sagaseta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

(2012) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY