Asiaticoside and polylysine-releasing collagen complex for effectively reducing initial inflammatory response using inflamed induced in vitro model

Inflammation is a significant clinical problem that can arise from full-thickness wounds or burn injuries or microbial disease. Although topical wound healing substances could promote rapid wound healing by preventing or reducing the consequences of inflammation, there still remains a need for the development of novel substances that can effectively reduce infection and inflammation in initial wound healing phase. In this study, collagen was combined with asiaticoside (AS) and epsilon-poly-L-lysine (epsilon PLL). This complex was then applied to in vitro models of infection and inflammation. Collagen-AS coatings inhibited the initial inflammatory response to LPS through a sustained release of AS, and a bilayer coating-epsilon PLL showed a notable antimicrobial effect using microbial infection test. In this study, we determined whether asiaticoside and epsilon PLL have anti-inflammatory and antibacterial effects through different mechanisms. Collectively, the collagen-AS/epsilon PLL complex indicated great therapeutic potentials for accelerate wound healing and the complex may be considered as a artificial scaffold substitute product to full-thickness wound healing.

Automated summary

The study found that the collagen-asiaticoside/epsilon-poly-L-lysine complex has significant effects in inhibiting the initial inflammatory response and demonstrating antimicrobial properties, potentially accelerating wound healing.