Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Bing Xia, Xue Gao, Jiaqi Qian, Shengyou Li, Beibei Yu, Yiming Hao, Bin Wei, Teng Ma, Haining Wu, Shijie Yang, Yi Zheng, Xueli Gao, Lingli Guo, Jianbo Gao, Yujie Yang, Yongfeng Zhang, Yitao Wei, Borui Xue, Yan Jin, Zhuojing Luo, Jin Zhang, Jinghui Huang
Summary: A superparamagnetic nanocomposite scaffold is developed to control the production of extracellular vesicles (EVs) by applying a rotating magnetic field. This non-invasive and remotely time-scheduled method accelerates tissue regeneration, including that of peripheral nerves.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yan Kong, Di Wang, Qufu Wei, Yumin Yang
Summary: In this study, a porous NDM-CS scaffold with high antimicrobial activity and high biocompatibility was prepared. The scaffold not only promoted nerve regeneration but also prevented wound infection. The positive effect on Schwann cells indicated its potential in nerve injury repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Neill Y. Li, Brandon Vorrius, Jonathan Ge, Zhen Qiao, Shuang Zhu, Julia Katarincic, Qian Chen
Summary: This study developed a biomimetic scaffold by incorporating matrilin-2 within a chitosan-derived porous scaffold to enhance peripheral nerve regeneration. Matrilin-2 was found to induce Schwann cell (SC) migration and enhance its adhesion, and a 2% chitosan with matrilin-2 formulation provided an optimal 3D porous architecture for SC interaction. Chemical modification of chitosan with lysine further improved neuronal adhesion and axonal outgrowth. Overall, the matrilin-2/K-chitosan scaffold has high potential for enhancing nerve repair through stimulating SC migration, neuronal adhesion, and axonal outgrowth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Youngchae Cho, Heeseok Jeong, Baeyeon Kim, Juwoong Jang, Yo-Seung Song, Deuk Yong Lee
Summary: By adjusting the content of PLLA and gelatin, the mechanical properties, water absorption capacity, degradation rate, and cell compatibility of the polymer membranes can be modified. High PLLA content improves the strength of the membranes and reduces their water absorption, while high gelatin content enhances both strength and water absorption.
Article
Biochemistry & Molecular Biology
Haiqiang Zhang, Dongwei Lan, Baiqing Wu, Xiang Chen, Xia Li, Zhi Li, Fangyin Dai
Summary: A silk fibroin/poly(vinylidene fluoride-co-hexafluoropropylene)/Ti3C2Tx (MXene) composite scaffold with piezoelectricity was developed using electrospinning technology. Cell experiments and in vivo studies demonstrated that this scaffold can promote the growth and proliferation of Schwann cells, enhance axon elongation and myelination, and have a favorable effect on motor and sensory function recovery in regenerative nerves.
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Xianhao Dong, Siyang Liu, Yueyue Yang, Shan Gao, Wenlei Li, Jiasong Cao, Ye Wan, Ziqi Huang, Guanwei Fan, Quan Chen, Hongjun Wang, Meifeng Zhu, Deling Kong
Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.
Article
Chemistry, Physical
Xiao Li, Ning He, Xiaojing Li, Xu Wang, Lei Zhan, Jialin Song, Wei-En Yuan, Yuanming Ouyang
Summary: A conductive GDY nanomaterial-loaded PCL scaffold was prepared and evaluated for its biocompatibility and effectiveness in peripheral nerve regeneration. The GDY/PCL scaffold significantly improved the proliferation, adhesion, and glial expression of Schwann cells, as well as promoted myelination and axonal growth in a rat sciatic nerve defect model. Additionally, upregulation of vascular factor expression suggested a potential role in angiogenesis for nerve repair.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yan Kong, Jiawei Xu, Qi Han, Tiantian Zheng, Linliang Wu, Guicai Li, Yumin Yang
Summary: In this study, a pure porcine decellularized nerve matrix conduit (xDNME) was successfully developed using an electrospinning technique without any additives. The xDNME conduit exhibited an obvious fiber structure and retained the natural components of the decellularized nerve tissue. In vivo experiments showed that xDNME significantly promoted the regeneration of rat sciatic nerve and exhibited comparable myelin sheath thickness and electrical signal transmission ability to the autologous nerve.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Neurosciences
Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Summary: This study reveals the essential role of EBP50 in the repair function of Schwann cells and regeneration following nerve injury. EBP50 deficiency leads to deficits in Schwann cell functions and delays nerve repair and functional recovery. Additionally, EBP50 enhances regeneration by binding and activating ErbB2.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Pei Feng, Jiye Jia, Li Yu, Anjie Min, Sheng Yang, Cijun Shuai
Summary: The addition of L-LA into PLLA scaffold promoted its degradation rate by weakening intermolecular forces and introducing hydrophilic functional groups, leading to reduced crystallinity and increased weight loss. The scaffold also exhibited good cytocompatibility for cell adhesion and growth with enhanced cell numbers and adhesion area over time.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Neurosciences
Emily L. Errante, Anthony Diaz, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. Brooks, Yee-Shuan Lee, S. Shelby Burks, Allan D. Levi
Summary: Peripheral nerve injury (PNI) is common in trauma patients, and severe PNI can be challenging to treat. The use of cell therapies, particularly Schwann cells, has shown effectiveness in PNI treatment. Our laboratory has demonstrated the effectiveness of Schwann cells in the treatment of severe PNI when used with axon guidance channels, but optimal cellular placement techniques are crucial.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Orthopedics
Guidong Shi, Dingyu Hao, Lei Zhang, Jia Qin, Guangyuan Tian, Boyuan Ma, Xianhu Zhou
Summary: Through analysis of normal and activated Schwann cells, this study identified key genes and proteins involved in endocytosis and exosomes which may control the molecular mechanism of peripheral nerve repair. The study suggests that targeting endocytosis-associated pathways in Schwann cells could be a novel therapeutic approach for nerve tissue engineering and regeneration.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Physical
Gaurav Sharma, Amit Kumar, Mu Naushad, Pooja Dhiman, Bharti Thakur, Alberto Garcia-Penas, Florian J. Stadler
Summary: In this study, a novel nanocomposite hydrogel with a C3N4/BiOI heterostructure supported on a gum acacia-crosslinked-poly(acrylamide) hydrogel was designed. The potential application of this nanocomposite hydrogel in mitigating crystal violet dye (CVD) in aqueous solutions was explored. Structural and functional analysis of the nanocomposite hydrogel was conducted, and various reaction parameters were optimized. The C3N4/BiOI heterostructure in the nanocomposite hydrogel exhibited a Z-scheme as the potential photocatalytic mechanism for CVD photodegradation, which was validated through COD and HR-MS analysis of the degradation pathways.
Review
Polymer Science
Soundouss Maliki, Gaurav Sharma, Amit Kumar, Maria Moral-Zamorano, Omid Moradi, Juan Baselga, Florian J. Stadler, Alberto Garcia-Penas
Summary: New developments require innovative ecofriendly materials with biocompatibility, biodegradability, and versatility. Chitosan, the second most abundant material in the world, has unique properties that can be used for various purposes, promoting the design and development of sustainable materials. For example, it can be used as an alternative for food packaging or in sustainable agriculture. Chitosan can also reduce pollution in other industrial processes. This review highlights important advances in the sustainable use of chitosan for promoting circular economy.
Article
Nanoscience & Nanotechnology
Priya Rittika Thakur, Shweta Sharma, Amit Kumar, Gaurav Sharma, Ayman A. Ghfar, Mu Naushad, Florian J. Stadler
Summary: In this study, a new Zn3V2O8/g-C3N4 Z-scheme nano-heterojunction was fabricated for efficient degradation of the pesticide diazinon under visible light irradiation. The optimized photocatalyst showed high degradation efficiency and structural stability. The improved photocatalytic activity of the heterojunction was attributed to various factors working together.
APPLIED NANOSCIENCE
(2022)
Review
Chemistry, Inorganic & Nuclear
Stephan Handschuh-Wang, Tomasz Gancarz, Sergey Uporov, Tao Wang, Eryuan Gao, Florian J. Stadler, Xuechang Zhou
Summary: This article reviews the technological developments of fusible and liquid metals, covering their history, current research, and industrial applications. The focus is on gallium-based alloys, highlighting important milestones and recent advancements, as well as their potential for future applications.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mehdihasan I. Shekh, Guangming Zhu, Wei Xiong, Weiling Wu, Florian J. Stadler, Dijit Patel, Chengtian Zhu
Summary: By forming multi-dynamic interactions and strong covalent interactions, stretchable, self-recoverable, conductive, and tough nanocomposite hydrogels (NCHGs) were successfully synthesized. These NCHGs exhibited high mechanical strength, toughness, stretchability, elasticity, and conductivity. The presence of Fe(III) ions and conducting fillers endowed excellent repeatability and stability in resistance change, along with ultra-broad sensitivity and minimal resistance change.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Saud Hashmi, Rafiq Ahmed, Adeel ur Rehman, Alberto Garcia-Penas, Awan Zahoor, Firoz Khan, Mohammad Vatankhah-Varnosfaderani, Thamraa Alshahrani, Florian J. Stadler
Summary: Hybrid hydrogels based on n-isopropylacrylamide, zwitterionic comonomer, and graphene oxide were synthesized to study their physical and mechanical properties. The compositional variation greatly affected the swelling characteristics of the hybrid hydrogels, while the mechanical properties such as elongation and compression were less influenced. Rheometric swelling measurements showed a strong covalent network, which increased with increasing content of zwitterions and GO. Kinetics of swelling followed Fickian dynamics and 2-step swelling pattern was observed for zwitterion-containing gels. The study also observed differences in swelling mechanism between hydrogels with 2D GO nano-fillers and 1D CNT nano-fillers, and differences in mechanical properties between elongation and compression modes.
Review
Energy & Fuels
Amit Kumar, Atul Khosla, Sunil Kumar Sharma, Pooja Dhiman, Gaurav Sharma, Lalitha Gnanasekaran, Mu. Naushad, Florian J. Stadler
Summary: This article provides a review on the transition from Z-scheme to S-scheme photocatalytic materials, discussing different types of heterojunctions and charge transfer mechanisms. It also presents the synthetic routes to S-scheme heterojunctions and highlights their current applications in pollutant degradation, hydrogen production, and CO2 conversion. The commercialization status and existing readiness and bottlenecks of S-scheme heterojunctions are also discussed.
Article
Chemistry, Multidisciplinary
Jun-Feng Liu, Zhan-Yu Wu, Florian J. Stadler, Yan-Fei Huang
Summary: The incorporation of ionic liquids (ILs) in solid-state polymer electrolytes (iono-SPEs) greatly enhances Li+ transport in polymer phases. By using a poly (vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) (PTC) as the framework of ILs, non-uniform Li+ transport among different phases is reduced. This is achieved through weaker adsorption energy of IL cations on PTC chains compared to PVDF and the higher dielectric constant of PTC facilitating the dissociation of Li-anions clusters. The LiFePO4/PTC iono-SPE/Li cells show stable cycling performance with high capacity retention after 1000 cycles at 1 C and 25 degrees C. This work provides a novel approach to induce uniform Li+ flux in iono-SPEs through polarity and dielectric design of the polymer matrix.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Stephan Handschuh-Wang, Muhammad Rauf, Tao Wang, Tiansheng Gan, Florian J. Stadler
Summary: This article introduces liquid metals as materials that can visually demonstrate extreme modulation of interfacial tension and possess a high degree of sustainability. Therefore, we recommend the use of liquid metals in chemical education in schools and universities.
CHEMIE IN UNSERER ZEIT
(2023)
Article
Biochemistry & Molecular Biology
Shi-Chang Wang, Shu-Tong Du, Saud Hashmi, Shu-Ming Cui, Ling Li, Stephan Handschuh-Wang, Xuechang Zhou, Florian J. Stadler
Summary: This study investigates the rheological properties of dual-network hydrogels based on acrylamide and sodium alginate under large deformations. The concentration of calcium ions affects the nonlinear behavior, and all gel samples exhibit strain hardening, shear thickening, and shear densification. The paper focuses on the systematic variation of the alginate concentration and the Ca2+ concentration in order to understand their impact on the hydrogel's properties.
Article
Polymer Science
Gaurav Sharma, Alberto Garcia-Penas, Yaksha Verma, Amit Kumar, Pooja Dhiman, Florian J. Stadler
Summary: This study successfully designed shape-oriented hydrogel nanospheres using a facile ultrasonication-supported crosslinked copolymerization technique. The chitosan-cl-poly(MMA) hydrogel nanospheres were characterized and found to have optimal rhodamine B dye adsorption capacity at pH 5. Nanohydrogel concentration also affected the adsorption capacity and percentage.
Article
Materials Science, Composites
Ge-Ge Zheng, Xin Lin, Zhen-Xing Wen, Yu-Hao Ding, Rui-Hui Yun, Gaurav Sharma, Amit Kumar, Florian J. Stadler
Summary: Photocatalytic degradation is crucial for wastewater treatment, and efficient degradation relies on photocatalytic systems with excellent light absorption, carrier separation efficiency, and surface-active sites. S-type heterojunctions, especially the BiFeO3/ZnIn2S4 heterojunction, show remarkable potential for efficient degradation. This study focuses on enhancing the photocatalytic degradation performance by introducing sulfur vacancy defects and morphology modifications to ternary indium metal sulfide and bismuth ferrite nanofibers. The optimized 30% BiFeO3/ZnIn2S4 heterojunction exhibits superior photocatalytic performance, with high sulfur vacancy concentration and enhanced electron transport efficiency. It achieved a remarkable 99% degradation of Evans blue within 45 minutes and a significant 68% degradation of ciprofloxacin within 90 minutes. These results provide a feasible approach for developing photocatalysts to address water pollution issues under practical conditions.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Education, Scientific Disciplines
Stephan Handschuh-Wang, Florian J. Stadler
Summary: New experiments on redox reactions at the liquid metal (Galinstan) interface are presented in this article. These experiments link redox reactions with standard potentials and metallurgy. The experiments offer a simple setup, easy handling without hazardous chemicals, a quick visual and memorable access to redox reactions, as well as the ability to reclaim and reuse the liquid metal (Galinstan).
Article
Chemistry, Physical
Shu-Ming Cui, Saud Hashmi, Wen-Qiang Li, Stephan Handschuh-Wang, Cheng-Tian Zhu, Shi-Chang Wang, Yan-Fei Huang, Guang-Ming Zhu, Florian J. Stadler
Summary: This paper investigates Pickering emulgels stabilized by graphene oxide (GO) with didodecyldimethylammonium bromide (DDAB) as an auxiliary surfactant and liquid paraffin as the oil phase, which are proved to be excellent 3D printable ink. The structure of these emulgels is elucidated by microscopy, broadband dielectric spectroscopy and rheology analysis. It is found that the increase of DDAB surfactant and GO-contents results in an increase of modulus and viscosity, a reduction of nonlinear regime limits, and a complex variation of normal forces.
Article
Chemistry, Physical
Jian-Ping Zeng, Jun-Feng Liu, Hua-Dong Huang, Shao-Cong Shi, Ben-Hao Kang, Chen Dai, Li-Wei Zhang, Zhi-Chao Yan, Florian J. Stadler, Yan-Bing He, Yan-Fei Huang
Summary: This study proposes a new method to improve the ionic conductivity of solid-state polymer electrolytes (SPEs) by enhancing the polarization of polymers using P(VDF-TrFE) as the matrix. The results show that P(VDF-TrFE) has a higher remnant polarization compared to PVDF, facilitating the dissociation of LiN(SO2CF3)2 and leading to significantly enhanced ionic conductivity. Stable cycling performance is also achieved in Li/P(VDF-TrFE) SPEs/Li batteries.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)