Article
Biochemistry & Molecular Biology
Supriya Tilvi, Rajesh Parvatkar, Keisham S. Singh, Prabha Devi
Summary: The marine fungus Aspergillus flavipes isolated from Goa, India, showed anti-inflammatory activity by blocking interleukin-6 and tumor necrosis factor-alpha production. Chemical investigation led to the isolation of compounds like (+)-terrein and butyrolactone I, which exhibited inhibition activity. Further exploration of these compounds in the therapeutic area is warranted.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Ya-Hui Zhang, Hui-Fang Du, Wen-Bin Gao, Wan Li, Fei Cao, Chang-Yun Wang
Summary: Three new polyketides were isolated from a marine-derived fungus, and their structures and configurations were determined. These compounds showed anti-inflammatory activities, with compounds 5 and 6 exhibiting the strongest effects.
Article
Biotechnology & Applied Microbiology
Weihao Chen, Chunmei Chen, Jieyi Long, Sujuan Lan, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Junfeng Wang, Yonghong Liu
Summary: In this study, two new compounds were isolated from a deep-sea derived fungus, including the first lumazine peptide reported from a deep-sea derived fungus. These compounds showed significant activity against alpha-glucosidase, and compounds 4 and 9 exhibited strong antibacterial activity against Staphylococcus aureus.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Chemistry, Medicinal
Chunmei Chen, Xue Ren, Huaming Tao, Wenteng Cai, Yuchi Chen, Xiaowei Luo, Peng Guo, Yonghong Liu
Summary: A new linear polyketide named aspormisin A, along with five known polyketides, was isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. The structures of these compounds were determined and their anti-inflammatory activities were evaluated. Compound 2 showed promising inhibitory effects on the release of pro-inflammatory cytokines both in vitro and in vivo. These findings provide a basis for the further development of linear polyketides as potential anti-inflammatory agents.
Article
Microbiology
Viridiana Morales-Sanchez, Carmen E. Diaz, Elena Trujillo, Sonia A. Olmeda, Felix Valcarcel, Ruben Munoz, Maria Fe Andres, Azucena Gonzalez-Coloma
Summary: The ethyl acetate extract from the endophytic fungus Aspergillus sp. SPH2 showed potential biocontrol properties against various plant pathogens, insect pests, and plant parasites. Compound 1, mellein, demonstrated strong ixodicidal effects, while compound 2, neoaspergillic acid, exhibited potent antifungal effects. The study also suggested that compound 2 may be the biosynthetic precursor of compound 3, neohydroxyaspergillic acid.
Article
Plant Sciences
Chengzeng Zhou, Xun Cao, Yichao Ge, Xiaodan Wu, Zunjing Zhang, Yihan Ma, Jeroen S. Dickschat, Bin Wu
Summary: In this study, the discovery of talaropeptins A and B from a marine-derived fungus is reported. These tripeptides exhibit an unusual heterocyclic scaffold and an N-trans-cinnamoyl moiety. The biosynthesis pathway of talaropeptins was elucidated through bioinformatic analysis and gene inactivation. The chemical structures of the compounds were determined using NMR spectroscopy and mass spectrometry, and their absolute configurations were established using electronic circular dichroism calculations and Marfey's method. Additionally, talaropeptins A and B showed moderate antifungal activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Rui Zhang, Haifeng Wang, Baosong Chen, Huanqin Dai, Jingzu Sun, Junjie Han, Hongwei Liu
Summary: In this study, six new compounds and thirty-nine known ones were isolated from the marine-derived fungus Aspergillus fumigatus H22. Nearly half of the compounds exhibited antibacterial activity, especially compounds 8 and 11, and 33-38 showed excellent antimicrobial activities against MRSA.
Article
Microbiology
Mohamed E. Elawady, Ahmed A. Hamed, Wamedh M. Alsallami, Ebtsam Z. Gabr, Mohamed O. Abdel-Monem, Mervat G. Hassan
Summary: Endophytic fungi are unpredictable microorganisms that produce diverse secondary metabolites with biological activity, enhancing the host's stress tolerance. These metabolites have potential applications in agriculture, pharmacy, and medicine. This study investigated the anti-acetylcholinesterase activity of secondary metabolites extracted from endophytic fungi.
Article
Biochemistry & Molecular Biology
Hassan Mohamed, Weaam Ebrahim, Mona El-Neketi, Mohamed F. Awad, Huaiyuan Zhang, Yao Zhang, Yuanda Song
Summary: Endophytic fungi, such as black aspergilli, have the potential to produce bioactive secondary metabolites. This study isolated 25 endophytic fungal strains associated with Malus domestica and identified one strain, Aspergillus tubingensis strain AN103, that showed the highest activity. Chemical investigations of its fermented cultures yielded four compounds, which exhibited moderate-to-potent antibacterial, antifungal, and cytotoxic activities. These compounds have the potential to be developed into drugs for various medical and pharmaceutical applications.
Article
Biochemistry & Molecular Biology
Ibrahim Seyda Uras, Sherif S. Ebada, Michal Korinek, Amgad Albohy, Basma S. Abdulrazik, Yi-Hsuan Wang, Bing-Hung Chen, Jim-Tong Horng, Wenhan Lin, Tsong-Long Hwang, Belma Konuklugil
Summary: A marine-derived fungus was found to contain two potentially active compounds that could be developed into new remedies for treating COVID-19 and related inflammatory complications.
Article
Biochemistry & Molecular Biology
George Hsiao, Wei-Chiung Chi, Chia-Hao Chang, Yin-Ru Chiang, Yan-Jie Fu, Tzong-Huei Lee
Summary: Marine fungi from Taiwanese marine algae were studied for their potential as a source of bioactive compounds. The ethyl acetate extract of the fermented products of Aspergillus terreus NTU243 showed significant antimicrobial activities. Further investigation led to the isolation and purification of 16 compounds, including four previously undescribed compounds. These compounds exhibited anti-inflammatory activities by inhibiting nitric oxide production and suppressing matrix metalloproteinase activity.
Article
Plant Sciences
Xiang Guo, Qinyu Meng, Jie Liu, Jingshuai Wu, Hongli Jia, Dong Liu, Yucheng Gu, Jianrong Liu, Jian Huang, Aili Fan, Wenhan Lin
Summary: Bioassay-guided fractionation, combined with LC-MS and NMR detection, led to the discovery of six new alkaloids from a marine gorgonian-derived fungus. Among them, sclerotiamides C and F showed significant inhibition against tumor cell lines, and sclerotiamide C induced apoptosis in cervical cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Jin Yang, Lizhi Gong, Miaomiao Guo, Yu Jiang, Yi Ding, Zhijie Wang, Xiujuan Xin, Faliang An
Summary: Six new prenylated indole diketopiperazine alkaloids, along with eight known analogues, were isolated from the marine-derived endophytic fungus Aspergillus sp. YJ191021. Compound 1 exhibited moderate antifungal, antibacterial, and anti-inflammatory activities, indicating its potential as a bioactive compound.
Article
Biochemistry & Molecular Biology
Elena V. Girich, Phan Thi Hoai Trinh, Liliana E. Nesterenko, Roman S. Popov, Natalya Yu Kim, Anton B. Rasin, Ekaterina S. Menchinskaya, Aleksandra S. Kuzmich, Ekaterina A. Chingizova, Artem S. Minin, Ngo Thi Duy Ngoc, Tran Thi Thanh Van, Ekaterina A. Yurchenko, Anton N. Yurchenko, Dmitry V. Berdyshev
Summary: The metabolic profile of a sponge-associated fungal strain, Aspergillus sp. 1901NT-1.2.2, was investigated using HPLC MS technique. The analysis revealed more than 23 peaks in the HPLC MS chromatogram, with two minor peaks identified as endocrocin and terpene derivative. The main compound, vismione E, was isolated and found to exhibit high cytotoxic activity against human breast cancer MCF-7 cells, with low toxicity for normal human breast MCF-10A cells. Vismione E inhibits MCF-7 cell proliferation, arrests the cell cycle in the G1 phase, and negatively affects cell migration. Molecular docking suggests that vismione E targets the IMPDH2 enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Tran Hong Quang, Nguyen Viet Phong, Dang Viet Anh, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Nguyen Quang Trung, Hyuncheol Oh, Nguyen Hoai Nam, Chau Van Minh
Summary: In this study, multiple new secondary metabolites were isolated from a culture fermentation of the soybean-derived fungus Aspergillus versicolor, showing cytotoxic effects against human cancer cells and antimicrobial activities against Enterococcus faecalis and Candida albicans. The investigation contributes to understanding the chemical constituents of soybean-derived A. versicolor and suggests further exploration of bioactive metabolites for therapeutic purposes.
PHYTOCHEMISTRY LETTERS
(2021)