Biotechnological Production of the Sunscreen Pigment Scytonemin in Cyanobacteria: Progress and Strategy

Combining Random Mutagenesis and Metabolic Engineering for Enhanced Tryptophan Production in Synechocystis sp. PCC 6803

(2020) Arnav Deshpande et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Increased ethylene production by overexpressing phosphoenolpyruvate carboxylase in the cyanobacterium Synechocystis PCC 6803

(2020) Claudia Durall et al.   Biotechnology for Biofuels

Photoprotective role of UV-screening pigment scytonemin against UV-B-induced damages in the heterocyst-forming cyanobacterium Nostoc sp. strain HKAR-2

(2020) Abha Pandey et al.   Brazilian Journal of Botany

Two-stage cultivation strategy for the improvement of pigment productivity from high-density heterotrophic algal cultures

(2020) Urim Kim et al.   BIORESOURCE TECHNOLOGY

Phosphoenolpyruvate carboxylase from the cyanobacterium Synechocystis sp. PCC 6803 is under global metabolic control by P II signaling

(2020) Jörg Scholl et al.   MOLECULAR MICROBIOLOGY

Aromatic Amino Acids: A Complex Network Ripe for Future Exploration

(2020) Joseph H. Lynch et al.   TRENDS IN PLANT SCIENCE

High density cultivation for efficient sesquiterpenoid biosynthesis in Synechocystis sp. PCC 6803

(2020) Dennis Dienst et al.   Scientific Reports

Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment

(2020) Moo Rim Kang et al.   Marine Drugs

Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria

(2020) Rui Miao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Accelerating lipid production in freshwater alga Chlorella sorokiniana SDEC-18 by seawater and ultrasound during the stationary phase

(2020) Zhen Xie et al.   RENEWABLE ENERGY

Genomic and transcriptomic insights into the survival of the subaerial cyanobacterium Nostoc flagelliforme in arid and exposed habitats

(2019) Jin-Long Shang et al.   ENVIRONMENTAL MICROBIOLOGY

Metabolic engineering of microorganisms for production of aromatic compounds

(2019) Damla Huccetogullari et al.   Microbial Cell Factories

Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of l-DOPA from d-glucose

(2019) Eric Fordjour et al.   Microbial Cell Factories

Timing the Evolutionary Advent of Cyanobacteria and the Later Great Oxidation Event Using Gene Phylogenies of a Sunscreen

(2019) Ferran Garcia-Pichel et al.   mBio

Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli

(2019) Di Cui et al.   JOURNAL OF STRUCTURAL BIOLOGY

Potential of two-stage cultivation in microalgae biofuel production

(2019) Senthil Nagappan et al.   FUEL

Glycogen metabolism supports photosynthesis start through the OPP pathway in cyanobacteria

(2019) Shrameeta Shinde et al.   PLANT PHYSIOLOGY

Potential of cyanobacterial secondary metabolites as biomarkers for paleoclimate reconstruction

(2019) Dijana Lalić et al.   CATENA

Bioinspired biomolecules: Mycosporine-like amino acids and scytonemin from Lyngbya sp. with UV-protection potentialities

(2019) Susana Fuentes-Tristan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Metabolic engineering of Synechocystis sp. PCC 6803 for the production of aromatic amino acids and derived phenylpropanoids

(2019) Laura Furelos Brey et al.   METABOLIC ENGINEERING

CARS microscopy of scytonemin in cyanobacteria Nostoc commune

(2018) Petras Venckus et al.   JOURNAL OF RAMAN SPECTROSCOPY

Temperature enhanced succinate production concurrent with increased central metabolism turnover in the cyanobacterium Synechocystis sp. PCC 6803

(2018) Tomohisa Hasunuma et al.   METABOLIC ENGINEERING

Two distinct structures of the sandwich complex of scytonemin with iron and their relevance to astrobiology

(2018) Tereza Varnali et al.   STRUCTURAL CHEMISTRY

Metabolic relation of cyanobacteria to aromatic compounds

(2018) Beata Żyszka-Haberecht et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioinformatic, phylogenetic, and chemical analysis of the UV-absorbing compounds scytonemin and mycosporine-like amino acids from the microbial mat communities of Shark Bay, Australia

(2018) Paul M. D'Agostino et al.   ENVIRONMENTAL MICROBIOLOGY

The Widely Conserved ebo Cluster Is Involved in Precursor Transport to the Periplasm during Scytonemin Synthesis in Nostoc punctiforme

(2018) Kevin Klicki et al.   mBio

Enhancing algal biomass and lipid production by phycospheric bacterial volatiles and possible growth enhancing factor

(2018) Kichul Cho et al.   Algal Research-Biomass Biofuels and Bioproducts

Cyanobacteria: Promising biocatalysts for sustainable chemical production

(2017) Cory J. Knoot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme I facilitates reverse flux from pyruvate to phosphoenolpyruvate in Escherichia coli

(2017) Christopher P. Long et al.   Nature Communications

The effects of the exopolysaccharide and growth rate on the morphogenesis of the terrestrial filamentous cyanobacteriumNostoc flagelliforme

(2017) Lijuan Cui et al.   Biology Open

Allosteric Inhibition of Phosphoenolpyruvate Carboxylases is Determined by a Single Amino Acid Residue in Cyanobacteria

(2017) Masahiro Takeya et al.   Scientific Reports

Improving isopropanol tolerance and production of Clostridium beijerinckii DSM 6423 by random mutagenesis and genome shuffling

(2016) H. Máté de Gérando et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Extracellular Polysaccharide Production in a Scytonemin-Deficient Mutant of Nostoc punctiforme Under UVA and Oxidative Stress

(2016) Tanya Soule et al.   CURRENT MICROBIOLOGY

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

(2016) Peyman Derikvand et al.   EUROPEAN JOURNAL OF PHYCOLOGY

The response regulator Npun_F1278 is essential for scytonemin biosynthesis in the cyanobacteriumNostoc punctiformeATCC 29133

(2016) Sejuti Naurin et al.   JOURNAL OF PHYCOLOGY

Scytonemin Plays a Potential Role in Stabilizing the Exopolysaccharidic Matrix in Terrestrial Cyanobacteria

(2016) Xiang Gao   MICROBIAL ECOLOGY

Bacteria increase arid-land soil surface temperature through the production of sunscreens

(2016) Estelle Couradeau et al.   Nature Communications

The plastid genome of some eustigmatophyte algae harbours a bacteria-derived six-gene cluster for biosynthesis of a novel secondary metabolite

(2016) Tatiana Yurchenko et al.   Open Biology

Mutational Studies of Putative Biosynthetic Genes for the Cyanobacterial Sunscreen Scytonemin in Nostoc punctiforme ATCC 29133

(2016) Daniela Ferreira et al.   Frontiers in Microbiology

Cyanobacterial Sunscreen Scytonemin: Role in Photoprotection and Biomedical Research

(2015) Rajesh Prasad Rastogi et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria

(2015) Sara B. Pereira et al.   Scientific Reports

The high-energy radiation protectant extracellular sheath pigment scytonemin and its reduced counterpart in the cyanobacterium Scytonema sp. R77DM

(2014) Rajesh P. Rastogi et al.   BIORESOURCE TECHNOLOGY

Distribution of scytonemin in endolithic microbial communities from halite crusts in the hyperarid zone of the Atacama Desert, Chile

(2014) Petr Vítek et al.   FEMS MICROBIOLOGY ECOLOGY

Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway

(2014) Tomohiro Itoh et al.   FOOD AND CHEMICAL TOXICOLOGY

A sustainable route to produce the scytonemin precursor using Escherichia coli

(2014) Sailesh Malla et al.   GREEN CHEMISTRY

Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds

(2014) Alberto Rodriguez et al.   Microbial Cell Factories

Raman spectroscopic identification of scytonemin and its derivatives as key biomarkers in stressed environments

(2014) T. Varnali et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genetic engineering of Escherichia coli to enhance production of l-tryptophan

(2013) Jian Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Theoretical Study of Novel Complexed Structures for Methoxy Derivatives of Scytonemin: Potential Biomarkers in Iron-Rich Stressed Environments

(2013) Tereza Varnali et al.   ASTROBIOLOGY

Partial characterization, UV-induction and photoprotective function of sunscreen pigment, scytonemin from Rivularia sp. HKAR-4

(2013) Rajesh P. Rastogi et al.   CHEMOSPHERE

Characterization of UV-screening compounds, mycosporine-like amino acids, and scytonemin in the cyanobacteriumLyngbyasp. CU2555

(2013) Rajesh P. Rastogi et al.   FEMS MICROBIOLOGY ECOLOGY

Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in human T-lymphoid cell line Jurkat cells

(2013) Tomohiro Itoh et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of UV-B radiation on the synthesis of UV-absorbing compounds in a terrestrial cyanobacterium, Nostoc flagelliforme

(2013) Haifeng Yu et al.   JOURNAL OF APPLIED PHYCOLOGY

Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan

(2013) G. Li et al.   MICROBIOLOGY-SGM

Scytonemin inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in multiple myeloma cells

(2013) Guojun Zhang et al.   TUMOR BIOLOGY

An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase

(2013) Heejin Yoo et al.   Nature Communications

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

(2012) Hiroshi Maeda et al.   Annual Review of Plant Biology

Current knowledge of the Escherichia coli phosphoenolpyruvate–carbohydrate phosphotransferase system: peculiarities of regulation and impact on growth and product formation

(2012) Adelfo Escalante et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Modification of tryptophan transport system and its impact on production of l-tryptophan in Escherichia coli

(2012) Qian Liu et al.   BIORESOURCE TECHNOLOGY

The cyanobacterial UV-absorbing pigment scytonemin displays radical-scavenging activity

(2012) Kei Matsui et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Salinity induced synthesis of UV-screening compound scytonemin in the cyanobacterium Lyngbya aestuarii

(2012) Jnanendra Rath et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Recent advances in engineering the central carbon metabolism of industrially important bacteria

(2012) Maria Papagianni   Microbial Cell Factories

One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli

(2012) Pengfei Gu et al.   Microbial Cell Factories

Subboreal aridity and scytonemin in the Holocene Black Sea

(2012) James M. Fulton et al.   ORGANIC GEOCHEMISTRY

The biosynthesis of cyanobacterial sunscreen scytonemin in intertidal microbial mat communities

(2011) Emily P. Balskus et al.   FEMS MICROBIOLOGY ECOLOGY

Development of l-tryptophan production strains by defined genetic modification in Escherichia coli

(2011) Zhi-Jun Zhao et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Microbial ultraviolet sunscreens

(2011) Qunjie Gao et al.   NATURE REVIEWS MICROBIOLOGY

Fatty acid production in genetically modified cyanobacteria

(2011) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial sunscreens

(2011) Roland J. Siezen   Microbial Biotechnology

Iron-Scytonemin Complexes: DFT Calculations on New UV Protectants for Terrestrial Cyanobacteria and Astrobiological Implications

(2010) Tereza Varnali et al.   ASTROBIOLOGY

Biologically active secondary metabolites from marine cyanobacteria

(2010) Joshawna K Nunnery et al.   CURRENT OPINION IN BIOTECHNOLOGY

Complementary UV-Absorption of Mycosporine-like Amino Acids and Scytonemin is Responsible for the UV-Insensitivity of Photosynthesis in Nostoc flagelliforme

(2010) Lorenzo Ferroni et al.   Marine Drugs

Organization, Evolution, and Expression Analysis of the Biosynthetic Gene Cluster for Scytonemin, a Cyanobacterial UV-Absorbing Pigment

(2009) C. M. Sorrels et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A comparative genomics approach to understanding the biosynthesis of the sunscreen scytonemin in cyanobacteria

(2009) Tanya Soule et al.   BMC GENOMICS

Gene Expression Patterns Associated with the Biosynthesis of the Sunscreen Scytonemin in Nostoc punctiforme ATCC 29133 in Response to UVA Radiation

(2009) T. Soule et al.   JOURNAL OF BACTERIOLOGY

An Enzymatic Cyclopentyl[b]indole Formation Involved in Scytonemin Biosynthesis

(2009) Emily P. Balskus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

(2009) Kenji Nakahigashi et al.   Molecular Systems Biology

Effects of nitrogen source on the synthesis of the UV-screening compound, scytonemin, in the cyanobacterium Nostoc punctiforme PCC 73102

(2008) Erich D. Fleming et al.   FEMS MICROBIOLOGY ECOLOGY

Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin

(2008) Emily P. Balskus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY