Journal
MACROMOLECULAR BIOSCIENCE
Volume 21, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202100007
Keywords
cancer theranostics; carbon dots; poly(amidoamine) dendrimers; sensing
Funding
- National Key R&D Program of China [2017YFE0196200]
- Shanghai Education Commission through the Shanghai Leading Talents Program
- Science and Technology Commission of Shanghai Municipality [19410740200, 20520710300, 19XD1400100]
- National Natural Science Foundation of China [81761148028, 21773026]
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The design of intelligent hybrid nanoparticles combining diagnosis and therapy components is crucial in nanomedicine. PAMAM dendrimers and CDs, due to their unique advantages, can be constructed as perfect nanohybrids for various biomedical applications, particularly in cancer nanomedicine.
Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.
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