Review
Biochemistry & Molecular Biology
Ashok Kumar, Vihang A. Narkar
Summary: This review proposes nuclear receptors as potential candidates for ischemic muscle repair in peripheral arterial disease (PAD), focusing on their roles in muscle angiogenesis, oxidative metabolism, mitochondrial biogenesis, and muscle regeneration. The article also identifies gaps in our understanding of nuclear receptor signaling in skeletal muscle and suggests future research directions.
Review
Medicine, Research & Experimental
Jingxuan Han, Lailiu Luo, Olivia Marcelina, Vivi Kasim, Shourong Wu
Summary: Peripheral artery disease (PAD) poses a significant challenge to society and its prevalence is expected to increase in the coming years. Patients in severe stages of PAD are at high risk of amputation and death, leading to decreased quality of life and socio-economic burden. Therapeutic angiogenesis has emerged as a potential strategy for treating PAD, but further efforts are needed to address certain issues.
Article
Endocrinology & Metabolism
Benedetta Maria Bonora, Mattia Albiero, Mario Luca Morieri, Roberta Cappellari, Francesco Ivan Amendolagine, Marta Mazzucato, Alberto Zambon, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini
Summary: This study aimed to investigate the effect of fenofibrate on circulating haematopoietic stem/progenitor cells (HSPCs) in patients with diabetic retinopathy. The results showed that fenofibrate significantly increased the levels of HSPCs expressing CD34 and/or CD133, potentially explaining its role in reducing retinopathy progression.
Article
Cardiac & Cardiovascular Systems
Abdelrahman A. Zaied, Masuko Ushio-Fukai, Tohru Fukai, Anita Kovacs-Kasa, Suhib Alhusban, Varadarajan Sudhahar, Vijay C. C. Ganta, Brian H. H. Annex
Summary: In endothelial cells, PFKFB3 plays a crucial role in regulating glycolysis, which is the main pathway for ATP generation. Both VEGF(165)a and microRNA-93 promote angiogenesis. In peripheral artery disease models, microRNA-93 treatment improves perfusion recovery, while VEGF(165)a treatment does not. This suggests that activating the glycolysis pathway to enhance angiogenesis may have therapeutic advantages.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Surgery
Il-Su Jo, Hyon-Jong Kim, Myong-Hwan Chae, Un-Chol Kwon, Gwang-Hak Ju, Un Song, Chol-Ho Hyon, Il-Su Kim
Summary: Combined therapy of autologous monocular bone marrow cell transplantation and sympathectomy is feasible and effective for patients with peripheral arterial disease, significantly improving walking distance and ankle-brachial index.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Multidisciplinary Sciences
Tomohiko Shindo, Kenta Ito, Tsuyoshi Ogata, Ryo Kurosawa, Kumiko Eguchi, Yuta Kagaya, Kenichiro Hanawa, Yuhi Hasebe, Kensuke Nishimiya, Takashi Shiroto, Jun Takahashi, Yasuo Okumura, Teruo Noguchi, Yukio Ozaki, Hiroyuki Daida, Nobuhisa Hagiwara, Tohru Masuyama, Taishiro Chikamori, Yoshihiro Fukumoto, Kenichi Tsujita, Hiroshi W. Kanai, Satoshi W. Yasuda, Hiroaki W. Shimokawa
Summary: This study aimed to evaluate the effectiveness and safety of low-intensity pulsed ultrasound (LIPUS) therapy in patients with refractory angina pectoris. The results showed that LIPUS therapy did not further improve chest pain in these patients and further confirmation is needed in a larger trial.
Article
Clinical Neurology
Antonio Uccelli, Alice Laroni, Rehiana Ali, Mario Alberto Battaglia, Morten Blinkenberg, Lou Brundin, Michel Clanet, Oscar Fernandez, James Marriot, Paolo Muraro, Seyed Massood Nabavi, Roberto S. Oliveri, Ernst Radue, Cristina Ramo Tello, Irene Schiavetti, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mark S. Freedman
Summary: The MESEMS study aimed to evaluate the safety and activity of autologous bone marrow-derived MSCs in patients with active multiple sclerosis. The results showed that MSC treatment did not affect GELs and does not support its use in treating multiple sclerosis.
Article
Cardiac & Cardiovascular Systems
Brian H. Annex, John P. Cooke
Summary: PAD is a significant global cause of disability and mortality, primarily due to atherosclerotic obstructions in the large arteries to the leg(s). Despite advances in surgical and endovascular procedures, treatment outcomes may be suboptimal at times due to comorbid conditions or severe microvascular disease.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Oncology
Sarah Prinsloo, Ted J. Kaptchuk, Dirk De Ridder, Randall Lyle, Eduardo Bruera, Diane Novy, Carlos H. Barcenas, Lorenzo G. Cohen
Summary: This study used a closed-loop brain-computer interface (BCI) to treat chemotherapy-induced peripheral neuropathy (CIPN). The results showed significant symptom reduction and improvements in the BCI and placebo control (PLC) groups, with the BCI group having larger effect size differences from the waitlist control group. These findings suggest that BCI is a promising treatment for CIPN and may have longer lasting effects.
Article
Genetics & Heredity
K. P. Thompson, J. Sykes, P. Chandakkar, P. Marambaud, N. T. Vozoris, D. A. Marchuk, M. E. Faughnan
Summary: The study did not demonstrate the effectiveness of doxycycline as a treatment for epistaxis in patients with HHT, although hemoglobin levels were significantly higher during treatment. Secondary analyses may help guide future trials in HHT.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Nutrition & Dietetics
Wagner Jorge Ribeiro Domingues, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato, Nelson Wolosker, Antonio Eduardo Zerati, Pedro Puech-Leao, Daniel Boari Coelho, Pollyana Mayara Nunhes, Andre Alberto Moliterno, Ademar Avelar
Summary: The study found that short- and long-term creatine supplementation did not significantly affect functional capacity and calf muscle oxygen saturation parameters in patients with symptomatic peripheral arterial disease.
Article
Critical Care Medicine
Stephan Rosenkranz, Jeremy Feldman, Vallerie V. McLaughlin, Franz Rischard, Tobias J. Lange, R. James White, Andrew J. Peacock, Felix Gerhardt, Ramin Ebrahimi, Gabriel Brooks, Carol Satler, Robert P. Frantz
Summary: The study aimed to compare the efficacy, safety, and tolerability of the ASK1 inhibitor selonsertib with placebo in patients with PAH. The results showed that selonsertib did not significantly reduce pulmonary vascular resistance or lead to clinical improvement in patients with PAH, but appeared to be safe and well tolerated.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Emergency Medicine
Ismail Ufuk Yildiz, Cagdas Yildirim, Ayhan Ozhasenekler, Alp Sener, Servan Gokhan
Summary: The study showed that lidocaine spray significantly reduced pain during radial arterial puncture compared to the placebo group. Therefore, lidocaine spray can be used for pain management related to radial arterial puncture.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Cell & Tissue Engineering
Yang Jingli, Wang Jing, Yasmeen Saeed
Summary: This article summarizes the role, mechanisms, and limitations of mesenchymal stem cell therapy in ischemic brain injury, both in preclinical and clinical applications. By evaluating previous research reports, it aims to provide a molecular basis for designing effective regenerative therapeutic strategies in the future.
STEM CELLS INTERNATIONAL
(2022)