Journal
JOURNAL OF THORACIC ONCOLOGY
Volume 16, Issue 4, Pages 537-545Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2021.01.1616
Keywords
Biomarker; Exploratory analysis; Confirmation analysis; Clinical trial
Categories
Funding
- National Institutes of Health (NIH) [P30CA15083]
- National Cancer Institute (NCI) [P50CA136393]
- NCI [P50CA102701, U10CA180882]
- NIH [U24CA213274, U54TR002243, P30CA068485]
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Biomarkers have diverse applications in disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring; Validated biomarkers are crucial in informing clinical decision making in the era of precision medicine; Team science partnerships can facilitate the translation of cutting-edge discoveries from bench to bedside, leading to improved patient care and outcomes.
Biomarkers have various applications including disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring. In this era of precision medicine, having validated biomarkers to inform clinical decision making is more important than ever. In this article, we discuss best the practices and potential issues in biomarker discovery and validation. We encourage team science partnerships to bring cutting-edge discovery from bench to bedside, leading to improved patient care and outcomes. Biomarkers have various applications including disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring. In this era of precision medicine, having validated biomarkers to inform clinical decision making is more important than ever. In this article, we discuss best the practices and potential issues in biomarker discovery and validation. We encourage team science partnerships to bring cutting-edge discovery from bench to bedside, leading to improved patient care and outcomes. ? 2021 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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