Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 115, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2020.104257
Keywords
Biocompatibility; Carrageenan; Polysaccharide; Capping agent; Hydrogel
Funding
- Department of Science and Technology-Science and Engineering Research Board, Government of India [PDF/2017/001574]
- DST-SERB, Government of India, New Delhi [SB/S2/RJN-201/2014]
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A novel biohybrid hydrogel nanocomposite made of carrageenan and gelatin protein was developed, with antibacterial activity tested against human pathogens and cytotoxic assay performed against lung cancer cells.
A novel biohybrid hydrogel nanocomposite made of natural polymer carrageenan and gelatin protein were developed. The silver nanoparticles were prepared using the carrageenan polymer as reduction and capping agent. Here, the Ag/Carrageenan was combined with gelatin hydrogel using glutaraldehyde having a cross-link role in order to create the biohybrid hydrogel nanocomposite. The manufactured composite performances were anaylised by UV-visible spectroscopy, Fourier Transform infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Energy dispersive X-ray (EDX) spectroscopy and Transmission Electron Microscopy (TEM) methods. The swelling behaviour of the Ag/Carrageenan-gelatin hybrid hydrogel nanocomposite was also analyzed. The antibacterial activity was tested against human pathogens viz. S. agalactiae 1661, S. pyogenes 1210 and E. coli. The bacterial cell wall damage of S. agalactiae 1661 was analyzed by scanning electron microscopy. The cytotoxic assay was performed against the A549 lung cancer cells.
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