Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen–Deuterium Exchange

Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor

(2020) Gregory H. Bird et al.   ACS Chemical Biology

Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics

(2020) Igor A. Kaltashov et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Hydrogen-Deuterium Exchange and Electron Capture Dissociation to Interrogate the Conformation of Gaseous Melittin Ions

(2019) Rita N. Straus et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein Ions Generated by Native Electrospray Ionization: Comparison of Gas Phase, Solution, and Crystal Structures

(2019) Maryam Bakhtiari et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry

(2019) Jie Zheng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Substrate-induced conformational dynamics of the dopamine transporter

(2019) Anne Kathrine Nielsen et al.   Nature Communications

Sequence and Conformational Analysis of Peptide–Polymer Bioconjugates by Multidimensional Mass Spectrometry

(2018) Sahar Sallam et al.   BIOMACROMOLECULES

Ion mobility in the pharmaceutical industry: an established biophysical technique or still niche?

(2018) Iain DG Campuzano et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Deconvolution of ion mobility mass spectrometry arrival time distributions using a genetic algorithm approach: Application to α 1 -antitrypsin peptide binding

(2018) Ganesh N. Sivalingam et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

In-Source Reduction of Disulfide-Bonded Peptides Monitored by Ion Mobility Mass Spectrometry

(2018) Bradley B. Stocks et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery

(2018) Joseph S. Redman et al.   MOLECULAR PHARMACEUTICS

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Collidoscope: An Improved Tool for Computing Collisional Cross-Sections with the Trajectory Method

(2017) Simon A. Ewing et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

(2016) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Enfuvirtide−PEG conjugate: A potent HIV fusion inhibitor with improved pharmacokinetic properties

(2016) Shuihong Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cis→Trans Isomerization of Pro7 in Oxytocin Regulates Zn2+ Binding

(2016) Daniel R. Fuller et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s)

(2016) Philippe Massonnet et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Retrospective Evaluation of the Use of Mass Spectrometry in FDA Biologics License Applications

(2016) Sarah Rogstad et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

(2016) Gregory H Bird et al.   Nature Chemical Biology

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Glycosylated Enfuvirtide: A Long-Lasting Glycopeptide with Potent Anti-HIV Activity

(2015) Shuihong Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide-based cancer therapy: Opportunity and challenge

(2014) Dongdong Wu et al.   CANCER LETTERS

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

(2014) Gregory H. Bird et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gas-Phase Helical Peptides Mimic Solution-Phase Behavior

(2014) Lindsay J. Morrison et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

(2014) Gregory H Bird et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties

(2013) Xiangguo (Eric) Shi et al.   ANALYTICAL CHEMISTRY

Partially Disordered Proteins Studied by Ion Mobility-Mass Spectrometry: Implications for the Preservation of Solution Phase Structure in the Gas Phase

(2013) Siavash Vahidi et al.   ANALYTICAL CHEMISTRY

Cis–Trans Isomerizations of Proline Residues Are Key to Bradykinin Conformations

(2013) Nicholas A. Pierson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide–Column Interactions and Their Influence on Back Exchange Rates in Hydrogen/Deuterium Exchange-MS

(2013) Joey G. Sheff et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Ion Mobility Mass Spectrometry of Peptide Ions: Effects of Drift Gas and Calibration Strategies

(2012) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Therapeutic peptides

(2012) Fernando Albericio et al.   Future Medicinal Chemistry

Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

(2012) Sophie R. Harvey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Multifaceted action of Fuzeon as virus–cell membrane fusion inhibitor

(2011) Avraham Ashkenazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Comparative structural studies of T-20 analogues using molecular dynamics

(2011) Parvesh Singh et al.   Computational and Theoretical Chemistry

Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis

(2010) Zuojun Guo et al.   Chemical Biology & Drug Design

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples

(2009) Peter S. Kutchukian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

(2008) Lars Konermann et al.   JOURNAL OF MASS SPECTROMETRY

T-20 and T-1249 HIV fusion inhibitors' structure and conformation in solution: a molecular dynamics study

(2007) António M. T. Martins Do Canto et al.   JOURNAL OF PEPTIDE SCIENCE