Article
Clinical Neurology
Melissa Lamar, Sue Leurgans, Alifiya Kapasi, Lisa L. Barnes, Patricia A. Boyle, David A. Bennett, Konstantinos Arfanakis, Julie A. Schneider
Summary: Cerebrovascular disease (CVD) pathologies, including vessel disease and tissue injury, contribute to Alzheimer and other forms of dementia. Mixed CVD, more common than single CVD, is associated with cognitive decline, and different combinations of mixed CVD have specific associations with cognitive decline in different domains.
Article
Clinical Neurology
Shahram Oveisgharan, Lei Yu, Ana Capuano, Zoe Arvanitakis, Lisa L. Barnes, Julie A. Schneider, David A. Bennett, Aron S. Buchman
Summary: The study found that a higher cardiovascular Framingham risk score (FRS) in older adults is associated with higher odds of some cerebrovascular disease (CVD) pathologies, but with low discrimination at the individual level. Further work is needed to develop a more robust risk score to identify adults at risk for accumulating CVD pathologies.
Review
Medicine, General & Internal
Tyler J. Loftus, Amanda C. Filiberto, Tezcan Ozrazgat-Baslanti, Saraswathi Gopal, Azra Bihorac
Summary: Patients with chronic critical illness (CCI) may suffer from chronic organ dysfunction, induced frailty, and worsening cardiovascular and renal diseases. Special consideration should be given to pharmacological therapies, behavioral modifications, and targeted therapies to improve patient outcomes. Further research is needed to clarify the pathophysiologic mechanisms of cardio-renal syndromes in CCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Luis Carlos Ferreira Mendonca, Miguel Bigotte Vieira, Joao Sergio Neves, Paulo Castro Chaves, Joao Pedro Ferreira
Summary: In this study, a simple and parsimonious prognostic model was developed and validated to predict cardio-kidney events and mortality. NT-proBNP, hs-cTnT, albuminuria, and eGFR were identified as the dominant predictors. This risk model showed good discrimination for multiple cardio-kidney outcomes in CKD.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Clinical Neurology
Kiana A. Scambray, Hannah L. Nguyen, S. Ahmad Sajjadi
Summary: The relationship between past medical histories and dementia-related neuropathologies was investigated using the NACC database. The study found that a history of hypertension was associated with vascular pathologies but had a lower likelihood of ADNP and other neurodegenerative pathologies.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Ramesh Kumar, Rajeev Nayan Priyadarshi, Utpal Anand
Summary: In recent years, there has been a sharp increase in the diagnosis of CKD among patients with liver cirrhosis, mainly attributed to risk factors such as diabetes, hypertension, and nonalcoholic fatty liver disease. A significant proportion of acute kidney injury in patients with decompensated cirrhosis turns into CKD, which can be either structural or functional. Limited literature exists on combined cirrhosis-CKD, presenting challenges for clinicians in diagnosing and treating CKD in cirrhosis patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Peripheral Vascular Disease
Michael G. Buhnerkempe, Vivek Prakash, Albert Botchway, Bemi Adekola, Jordana B. Cohen, Mahboob Rahman, Matthew R. Weir, Ana C. Ricardo, John M. Flack
Summary: The study showed that refractory hypertension (RfH) is associated with worse long-term health outcomes compared with treatment-resistant hypertension (TRH), including worsening renal and cardiovascular outcomes. However, there was no significant difference in the all-cause mortality between individuals with RfH and TRH.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Article
Clinical Neurology
Pedro Coelho, Joao Madureira, Ana Franco, Ana Rita Peralta, Carla Bentes, Alexandre Rainha Campos, Jasper Anink, Eleonora Aronica, Rafael Roque, Jose Pimentel
Summary: This study provides evidence for an increased burden of cerebral small vessel disease in neuropathological samples of patients with chronic epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Giulio Romano, Roberto Mioni, Nicola Danieli, Martina Bertoni, Elisa Croatto, Lucia Merla, Lucia Alcaro, Antonio Pedduzza, Xenia Metcalf, Alessandra Rigamonti, Cristiana Catena, Leonardo A. Sechi, GianLuca Colussi
Summary: In non-proteinuric patients with CKD of unknown etiology, increased intrarenal resistive index (RI) predicted both a faster decline in renal function and higher long-term mortality. However, as a single marker, it showed poor discrimination performance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Xiaosi Chen, Xinyuan Zhang, Zhizhong Gong, Yang Yang, Xiaohong Zhang, Qiyun Wang, Yanhong Wang, Rui Xie
Summary: This study investigated the relationship between diabetic retinopathy (DR) and diabetic nephropathy (DKD) in patients with type 2 diabetes mellitus (T2DM) and examined the role of circulating cytokines and dyslipidemia. The results showed that LDL-C and VEGF-D were independent risk factors for DR, while the albumin-to-creatinine ratio (uACR) was an independent risk factor for DR with DKD. The study also found that blood glucose levels and levels of PlGF and VEGF-D were closely correlated with the severity of uACR and the development of DR.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Luke J. Laffin, George L. Bakris
Summary: Chronic kidney disease and cardiovascular disease share common risk factors and pathogenic mechanisms, impacting a significant segment of the population. Patients with chronic kidney disease are more prone to develop cardiovascular disease, highlighting the importance of addressing the intersection between the two conditions.
CURRENT CARDIOLOGY REPORTS
(2021)
Article
Biology
Daopeng Dai, Zhengbin Zhu, Hui Han, Tian Xu, Shuo Feng, Wenli Zhang, Fenghua Ding, Ruiyan Zhang, Jinzhou Zhu
Summary: Chronic kidney disease (CKD) is associated with increased sulfation status, which contributes to monocyte/macrophage activation and may be involved in CKD-related atherosclerosis. Inhibition of sulfation may suppress CKD-related atherosclerosis and deserves further study.
Review
Cardiac & Cardiovascular Systems
Carmine Zoccali, Francesca Mallamaci, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Pantelis Sarafidis, Rajiv Agarwal, Patrick B. Mark, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Andrzej Wiecek
Summary: Chronic kidney disease (CKD) is a progressive condition that increases the risk of cardiovascular diseases. Traditional and non-traditional risk factors contribute to the progression of cardiovascular complications in CKD patients. Arterial disease in CKD patients is characterized by calcification and vascular stiffness. Recent clinical trials have shown promising potential treatments for CKD patients, including hypoxia-inducible factor prolyl hydroxylase inhibitors, intravenous iron for treating anemia, and sodium/glucose cotransporter-2 inhibitors. However, more research is needed in this area.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)