4.6 Article

Recent applications of ion mobility spectrometry in natural product research

Journal

Publisher

ELSEVIER
DOI: 10.1016/j.jpba.2020.113846

Keywords

Natural products; Secondary metabolites; Ion mobility spectrometry (IMS); Mass spectrometry; Liquid chromatography (LC); Gas chromatography (GC)

Funding

  1. Sasol
  2. Central Analytical Facility of Stellenbosch University
  3. National Research Foundation of South Africa [118530, 121613]

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Ion mobility spectrometry (IMS) plays a significant role in natural product analysis by enhancing the quality of mass spectral data, discriminating structurally similar secondary metabolites, and serving as an additional identification criterion.
Ion mobility spectrometry (IMS) is a rapid separation technique capable of extracting complementary structural information to chromatography and mass spectrometry (MS). IMS, especially in combination with MS, has experienced inordinate growth in recent years as an analytical technique, and elicited intense interest in many research fields. In natural product analysis, IMS shows promise as an additional tool to enhance the performance of analytical methods used to identify promising drug candidates. Potential benefits of the incorporation of IMS into analytical workflows currently used in natural product analysis include the discrimination of structurally similar secondary metabolites, improving the quality of mass spectral data, and the use of mobility-derived collision cross-section (CCS) values as an additional identification criterion in targeted and untargeted analyses. This review aims to provide an overview of the application of IMS to natural product analysis over the last six years. Instrumental aspects and the fundamental background of IMS will be briefly covered, and recent applications of the technique for natural product analysis will be discussed to demonstrate the utility of the technique in this field. (C) 2020 Elsevier B.V. All rights reserved.

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