Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 4, Pages 3546-3554Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02932
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Funding
- Key Scientific and Technological Project of Henan Province [202102110067, 212102110439]
- Henan University of Animal Husbandry and Economy [2019HNUAHEDF011, XKYCXJJ2020006]
- Natural Science Foundation of Henan Province [202300410188, 212300410152]
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In this study, the convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved via a cascade [3 + 2] cycloaddition between organo-cyanamides and alpha-haloamides under mild conditions in good to excellent yields (up to 99%). The resulting cyclic guanidines could be easily transformed into hydantoins through hydrolysis.
The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and alpha-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.
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