Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 80, Issue 3, Pages 210-219Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nlab001
Keywords
Brain trauma; Chronic traumatic encephalopathy; Neurodegenerative disorders; Tauopathy; Traumatic brain injury
Categories
Funding
- National Institute of Neurological Disorders and Stroke [1U01NS086659-01, 1U01NS086625-01, R01NS078337, R56NS078337, R01NS095252]
- Department of Defense [W81XWH-13-2-0064, W81XWH-14-1-0399]
- Department of Veterans Affairs, the Veterans Affairs Biorepository [CSP 501]
- National Institute of Aging [1R01AG061028-01]
- National Institute of Aging Boston University Alzheimer's Disease Center [P30AG13846, 0572063345-5]
- Department of Defense Peer Reviewed Alzheimer's Research Program (DoD-PRARP) [13267017]
- National Institute of Aging Boston University Framingham Heart Study [R01AG1649]
- National Operating Committee on Standards for Athletic Equipment
- Concussion Legacy Foundation
- Andlinger Foundation
- World Wrestling Entertainment
- National Football League
- National Institute on Aging [P50 AG05681, P01 AG03991]
Ask authors/readers for more resources
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with head trauma. A panel of neuropathologists established neuropathological criteria for CTE, identified characteristic pathological features, and proposed a minimum threshold for diagnosis and an algorithm to assess CTE severity.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern, based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as Low CTE or High CTE for use in future clinical, pathological, and molecular studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available