Article
Behavioral Sciences
Yolanda Balboa-Bandeira, Leire Zubiaurre-Elorza, M. Acebo Garcia-Guerrero, Naroa Ibarretxe-Bilbao, Natalia Ojeda, Javier Pena
Summary: Although studies on the effects of transcranial electrical stimulation (tES) on foreign language learning are limited, this study found that tRNS stimulation can enhance learning accuracy in foreign language vocabulary learning.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Health Care Sciences & Services
Rajan Kashyap, Sagarika Bhattacharjee, Ramaswamy Arumugam, Rose Dawn Bharath, Kaviraja Udupa, Kenichi Oishi, John E. Desmond, S. H. Annabel Chen, Cuntai Guan
Summary: The study introduced a dose-target determination index (DTDI) to quantify the focality of tDCS and found that individuals of different ages and genders show varying changes in focality when the current dose is increased. The nonlinear relationship between the injected tDCS current and the distribution of current density in the target ROI is predominant in older adults, with males exhibiting a stronger decline in focality. Higher current doses in older age can enhance the focality of stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Maeva Daoud, Ricardo Salvador, Nada El Youssef, Alexane Fierain, Elodie Garnier, Maria Chiara Biagi, Samuel Medina Villalon, Fabrice Wendling, Christian Benar, Giulio Ruffini, Fabrice Bartolomei
Summary: This study investigated the long-term effects of personalized, multisession, stereotactic-EEG (SEEG)-targeted multichannel tDCS on seizure frequency (SF) and functional connectivity (Fc) in patients with drug-resistant epilepsy. The results showed that after the treatment, five patients experienced a significant decrease in seizure frequency, and functional connectivity was also found to decrease in patients with a significant response.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Psychiatry
Theodoros Koutsomitros, Sandra A. Schwarz, Kenneth T. van der Zee, Teresa Schuhmann, Alexander T. Sack
Summary: This study assessed the feasibility and clinical effectiveness of home-administered transcranial direct current stimulation (tDCS) with asynchronous remote supervision in the treatment of depression. The results showed that the tDCS group had a significantly greater reduction in depression symptoms after 3 weeks of treatment compared to the treatment as usual (TAU) group.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
B. Gonzalez-Rodriguez, N. Serradell-Ribe, R. Viejo-Sobera, J. P. Romero-Munoz, Elena M. Marron
Summary: This systematic review evaluated the effectiveness of transcranial direct current stimulation (tDCS) in the rehabilitation of hemispatial neglect after stroke. The findings indicate that tDCS can effectively improve neglect recovery, particularly when combined with other interventions. However, due to the limited number of studies and certain design risks, categorical conclusions cannot be drawn at this time. Further research is needed to determine the advantages of tDCS in stroke patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sreerag Othayoth Vasu, Hanoch Kaphzan
Summary: Transcranial direct current stimulation (tDCS) is a technique that modulates spontaneous neurotransmitter release by regulating calcium channels in axon terminals, primarily through P/Q and N-type calcium channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yoonju Na, Jinuk Kim, Su-Hyun Lee, Jihye Kim, Jungsoo Lee, Se Young Shin, Won Hyuk Chang, Jin Whan Cho, Yun-Hee Kim
Summary: This study suggests that multichannel tDCS applied during treadmill gait training can improve gait velocity in patients with Parkinson's disease. The real tDCS group showed significant improvement in gait tests and some assessment measures, while the sham group did not. Therefore, tDCS may be an effective method for gait rehabilitation in Parkinson's disease, but further research is needed to confirm its effectiveness.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Tadeas Mares, Jakub Albrecht, Jozef Buday, Gabriela Podgorna, Thai Hong Le, Eva Magyarova, Katerina Poshor, Jakub Halik, Jan Buna, Vaclav Capek, Lenka Kostylkova, Johana Klasova, Vratislav Fabian, Martin Anders
Summary: In this study, a randomized, double-blinded, sham-controlled trial was conducted to investigate the effect of transcranial direct current stimulation (tDCS) on tinnitus. The results showed partial positive long-term effects of tDCS on auditory difficulties associated with tinnitus, as well as short-term negative effects on a specific aspect of general quality of life. However, the small sample size limited the statistical power of the analyzed items.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Forouzan Farahani, Greg Kronberg, Mohamad FallahRad, Hysell V. Oviedo, Lucas C. Parra
Summary: This study found that transcranial direct current stimulation (DCS) enhances synaptic plasticity by increasing postsynaptic somatic spiking, but also discovered that an increase in network activity may both boost and limit this enhancement.
Review
Clinical Neurology
Aprinda Indahlastari, Aprinda Cheshire, Alejandro Albizu, Stacey Alvarez-Alvarado, Emanuel M. Boutzoukas, Nicole D. Evangelista, Hanna K. Hausman, Jessica Kraft, Kailey Langer, Adam J. Woods
Summary: This study aimed to investigate the impact of tDCS on cognitive function in healthy older adults. The results showed that tDCS has the potential to improve cognitive aging, but the effects vary depending on individual differences and cognitive domains.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Engineering, Biomedical
Mayank Jog, Cole Anderson, Elizabeth Kim, Avery Garrett, Antoni Kubicki, Sara Gonzalez, Kay Jann, Marco Iacoboni, Roger Woods, Danny J. J. Wang, Katherine L. Narr
Summary: This study introduces a new technique for accurate electrode placement during repeated tES sessions. Using neuronavigation data, simulations, and CBF data, the results confirm the effectiveness and accuracy of the proposed technique for targeting specific cortical regions.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Psychology, Clinical
Rebecca Divarco, Perianen Ramasawmy, Frank Petzke, Andrea Antal
Summary: This article reviews the current research on the combined effects of low intensity transcranial electrical stimulation (tES) and meditation. The results suggest that pairing anodal transcranial direct current stimulation (tDCS) with meditation can improve individuals' physical, mental, and emotional well-being. However, further studies are needed to confirm the clinical relevance of this combination.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Swarna Buddha Nayok, Harsh Pathak, Satish Suhas, Vani H. Thimmashetty, Prakrithi Shivaprakash, Ragibommanahalli M. Madhu Sudhan, Vanteemar S. Sreeraj, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian
Summary: This study reported the use of a novel tDCS protocol in a patient with both schizophrenia and OCD, demonstrating clinical utility by reducing symptoms of both disorders.
Review
Neurosciences
Peiwei Hong, Yao Liu, Yang Wan, Hai Xiong, Yanming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the efficacy and safety of transcranial direct current stimulation (tDCS) for migraine treatment. The results showed that tDCS activated or inhibited specific brain areas could reduce the number of migraine days per month in patients with migraine. tDCS was found to be an effective, preventive, and safe treatment option for migraine.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Psychology, Multidisciplinary
Luiza Grycuk, Francesca Moruzzi, Elena Bardjesteh, Fiona Gaughran, Iain C. Campbell, Ulrike Schmidt
Summary: The study provides insights into the perceptions and experiences of individuals with schizophrenia regarding transcranial direct current stimulation (tDCS). Participants were concerned about the safety of tDCS, but educational materials and a good relationship with the researcher helped alleviate their fears. Although participants found tDCS uncomfortable, they agreed that the unpleasant sensations were short-lived and did not cause long-term anxiety.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Xin-lu Cai, Cheng-cheng Pu, Shu-zhe Zhou, Yi Wang, Jia Huang, Simon S. Y. Lui, Arne Moller, Eric F. C. Cheung, Kristoffer H. Madsen, Rong Xue, Xin Yu, Raymond C. K. Chan
Summary: This study found that schizophrenia patients have sensory integration deficits which are positively correlated with anterior cingulate cortex (ACC) glutamate levels. Multimodal analysis showed that in a specific network, blood oxygenation level dependent (BOLD) activation and task-dependent functional connectivity (FC) have opposite correlations between schizophrenia patients and healthy controls.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sofie Rahbek, Tim Schakel, Faisal Mahmood, Kristoffer H. H. Madsen, Marielle E. P. Philippens, Lars G. G. Hanson
Summary: The study extends a method for controlling the spatial point spread function (PSF) by optimizing the flip angles in the refocusing pulse train of diffusion-weighted SPLICE sequence, resulting in improved image quality with increased signal-to-noise ratio (SNR) and accurate diffusion coefficient estimates.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biochemical Research Methods
Konstantin Weise, Ole Numssen, Benjamin Kalloch, Anna Leah Zier, Axel Thielscher, Jens Haueisen, Gesa Hartwigsen, Thomas R. Knosche
Summary: This article describes a routine for precisely localizing cortical muscle representations in the primary motor cortex using transcranial magnetic stimulation (TMS) based on the functional relation between induced electric fields at the cortical level and peripheral muscle activation. This routine lays the foundation for TMS dosing metrics based on subject-specific cortical electric field thresholds and provides insights into structure-function relationships. The protocol involves constructing an individual head model using magnetic resonance imaging, recording motor-evoked potentials (MEPs) via electromyography during TMS, and computing induced electric fields with numerical modeling.
Article
Engineering, Biomedical
Sofie Rahbek, Faisal Mahmood, Michal R. Tomaszewski, Lars G. Hanson, Kristoffer H. Madsen
Summary: A new prediction framework was proposed in this study to utilize temporal dynamics of tissue features from repeated measurements. The framework was able to classify tumor types and predict the response to radiotherapy using MRI data analysis. The results showed accurate classification of pancreatic tumor types and prediction of tumor volume change. The classification of brain metastases also demonstrated some level of accuracy.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Sofie Johanna Nilsson, David Meder, Kristoffer Hougaard Madsen, Ivan Toni, Hartwig Roman Siebner
Summary: People are better at approaching reward-related cues and avoiding punishment-related cues than vice versa. This bias has been previously observed in arm movements but it is unknown whether it extends to distal dexterous actions such as gripping and slipping. This study shows that the bias towards affectively congruent cue-response mappings is also present in precision grip tasks.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Mikkel Pejstrup Agger, Else Rubaek Danielsen, Marcus Schultz Carstensen, N. Mai Nguyen, Maibritt Horning, Mark Alexander Henney, Christopher Boe Ravn Jensen, Anders Ohlhues Baandrup, Troels Wesenberg Kjaer, Kristoffer Hougaard Madsen, Kamilla Miskowiak, Paul Michael Petersen, Peter Hogh
Summary: This study investigated the potential therapeutic effect of 40 Hz neural activity on Alzheimer's disease. The results showed that treatment with 40 Hz Invisible Spectral Flicker (ISF) had no significant safety or adherence concerns, and there was a tendency towards improvement in cognition. However, further large-scale clinical trials are needed to validate the effect on hippocampal and ventricular volume.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, Research & Experimental
Mia Kolmos, Mads Just Madsen, Marie Louise Liu, Anke Karabanov, Katrine Lyders Johansen, Axel Thielscher, Karen Gandrup, Henrik Lundell, Soren Fuglsang, Esben Thade, Hanne Christensen, Helle Klingenberg Iversen, Hartwig Roman Siebner, Christina Kruuse
Summary: This study aims to test the feasibility and efficacy of personalized, multi-electrode anodal TDCS of the ipsilesional primary motor hand area (M1-HAND) in patients with subacute stroke and upper-extremity paresis, and assess the effects of TDCS on motor network connectivity and interhemispheric inhibition using functional MRI and transcranial magnetic stimulation. The results of this study may inform future personalized TDCS studies in patients with focal neurological deficits after stroke.
Article
Neurosciences
Kathleen E. Mantell, Nipun D. Perera, Sina Shirinpour, Oula Puonti, Ting Xu, Jan Zimmermann, Arnaud Falchier, Sarah R. Heilbronner, Axel Thielscher, Alexander Opitz
Summary: The study examined the impact of anatomical details in NHP models on NIBS electric field calculations, highlighting the effects of muscle tissue and head field of view on TES and TMS simulation results. Opposing effects were found between TES and TMS when comparing full head models to cropped head models, with significant changes in electric field strength observed.
Article
Neurosciences
Jesper Duemose Nielsen, Oula Puonti, Rong Xue, Axel Thielscher, Kristoffer Hougaard Madsen
Summary: This study compares the accuracy of forward solutions from SimNIBS, MNE-Python, and FieldTrip in generating realistic volume conductor models for EEG. The results show that SimNIBS is generally more accurate in terms of both field topography and magnitude. The method of electrode specification also affects the accuracy, with transformed measured positions from standard space yielding smaller errors.
Article
Neurosciences
Anke Ninija Karabanov, Gaetana Chillemi, Kristoffer Hougaard Madsen, Hartwig Roman Siebner
Summary: The study investigated bimanual control during dynamic changes in motor output generated by both hands. The results showed that the bilateral dorsal premotor cortex plays a role in increasing complexity of bimanual coordination by increasing coupling to the supplementary motor area (SMA), while SMA provides feedback about motor actions to the sensory system. The study used functional magnetic resonance imaging (MRI) to map the functional activity and connectivity of premotor and motor areas during bimanual pinch force control in different task contexts.
Article
Psychiatry
Line Korsgaard Johnsen, Kit Melissa Larsen, Soren Asp Fuglsang, Anna Hester Ver Loren van Themaat, William Frans Christiaan Baare, Kathrine Skak Madsen, Kristoffer Hougaard Madsen, Nicoline Hemager, Anna Krogh Andreassen, Lotte Veddum, Aja Neergaard Greve, Ayna Baladi Nejad, Birgitte Klee Burton, Maja Gregersen, Heike Eichele, Torben E. Lund, Vibeke Bliksted, Anne Amalie Elgaard Thorup, Ole Mors, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
Summary: This study examines children with familial high-risk of SZ or BP and finds that they may have impaired executive control and aberrant brain activation compared to population-based control children.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Geriatrics & Gerontology
Mikkel Pejstrup Agger, Maibritt Horning, Marcus Schultz Carstensen, Else Rubaek Danielsen, Anders Olhues Baandrup, Mai Nguyen, Peter Hogh, Kamilla Miskowiak, Paul Michael Petersen, Kristoffer Hougaard Madsen, Troels Wesenberg Kjaer
Summary: This article introduces a novel treatment method for patients with Alzheimer's disease (AD) - light-based 40 Hz brain stimulation. The clinical trial aims to evaluate the efficacy and safety of this treatment and measure the effect through a comprehensive assessment battery.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Proceedings Paper
Acoustics
Anders S. Olsen, Emil Ortvald, Kristoffer H. Madsen, Mikkel N. Schmidt, Morten Morup
Summary: The development of suitable models for dynamic functional connectivity is crucial for a better understanding of the brain's activity during rest and tasks. This study introduces mixture models and Hidden Markov models that consider the sign-symmetric distribution of eigenvectors on a hypersphere, and demonstrates their performance on synthetic and task-fMRI data.
2023 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING WORKSHOPS, ICASSPW
(2023)
Proceedings Paper
Acoustics
Qiang Li, Shujian Yu, Kristoffer H. Madsen, Vince D. Calhoun, Armin Iraji
Summary: This paper uses multivariate mutual information and Renyi matrix entropy to explore higher-order interactions in the brain. The results show that higher-order information interactions increase as the interaction order increases, and the correlation between Total Correlation and Dual Total Correlation also increases. Additionally, the significance difference between Dual Total Correlation and Total Correlation values indicates synergy dominance in the human brain during the resting state.
2023 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING WORKSHOPS, ICASSPW
(2023)