Article
Urology & Nephrology
Satoru Kudose, Dominick Santoriello, Andrew S. Bomback, Miroslav Sekulic, Ibrahim Batal, M. Barry Stokes, Iman A. Ghavami, Jung S. Kim, Maddalena Marasa, Katherine Xu, Yonatan Peleg, Jonathan Barasch, Pietro Canetta, Hila Milo Rasouly, Ali G. Gharavi, Glen S. Markowitz, Vivette D. D'Agati
Summary: This study reviewed kidney biopsies of 76 patients with COVID-19, identifying 23 cases of collapsing glomerulopathy and 7 cases of noncollapsing podocytopathies. It was found that dialysis was required for half of the Black patients with collapsing glomerulopathy patients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Chemistry, Analytical
Wen-Yu Su, Pin-Xian Du, Harvey M. Santos, Tzong-Shiann Ho, Batuhan Birol Keskin, Chi Ho Pau, An-Ming Yang, Yi-Yu Chou, Hsi-Chang Shih, Guan-Da Syu
Summary: This study utilized a multiplexed spike variant protein microarray (SVPM) to analyze the humoral immune response and neutralizing activity in COVID-19 patients, and found that severe patients had stronger inhibition of ACE2 binding to multiple variants.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Markus Hoffmann, Nadine Krueger, Sebastian Schulz, Anne Cossmann, Cheila Rocha, Amy Kempf, Inga Nehlmeier, Luise Graichen, Anna-Sophie Moldenhauer, Martin S. Winkler, Martin Lier, Alexandra Dopfer-Jablonka, Hans-Martin Jaeck, Georg M. N. Behrens, Stefan Poehlmann
Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly and shows resistance to most therapeutic antibodies. It also evades neutralization by antibodies induced by infection or vaccination more efficiently than the Delta variant. This suggests that therapeutic antibodies may not be effective against the Omicron variant, and double vaccination with BNT162b2 may not provide adequate protection against severe disease caused by this variant.
Article
Medicine, General & Internal
Stephanie J. Schrag, Jennifer R. Verani, Brian E. Dixon, Jessica M. Page, Kristen A. Butterfield, Manjusha Gaglani, Gabriela Vazquez-Benitez, Ousseny Zerbo, Karthik Natarajan, Toan C. Ong, Victoria Lazariu, Suchitra Rao, Ryan Beaver, Sascha R. Ellington, Nicola P. Klein, Stephanie A. Irving, Shaun J. Grannis, Salome Kiduko, Michelle A. Barron, John Midturi, Monica Dickerson, Ned Lewis, Melissa S. Stockwell, Edward Stenehjem, William F. Fadel, Ruth Link-Gelles, Kempapura Murthy, Kristin Goddard, Nancy Grisel, Nimish R. Valvi, Bruce Fireman, Julie Arndorfer, Deepika Konatham, Sarah Ball, Mark G. Thompson, Allison L. Naleway
Summary: This study found that maternal mRNA COVID-19 vaccination, including booster doses, provided protection against medically attended COVID-19. Vaccine effectiveness estimates were higher for COVID-19-associated hospitalizations compared to emergency department/urgent care visits, and lower for the Omicron variant than the Delta variant. Protection decreased over time, especially during the Omicron predominance.
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Urology & Nephrology
Giuliana Papalia, Simona Barbuto, Anita Campus, Gisella Vischini
Summary: SARS-CoV-2 infection often leads to kidney damage through various mechanisms. Although there is no definitive evidence of direct damage by the virus, recent literature suggests a possible association. Regardless of pulmonary involvement, SARS-CoV-2 infection is a poor prognostic factor. We present a challenging case of collapsing glomerulopathy and focal proliferative IgA-dominant glomerulonephritis in a patient with active hepatitis C virus (HCV), SARS-CoV-2 infection, and a history of cocaine abuse.
JOURNAL OF NEPHROLOGY
(2023)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Virology
Chao Wang, Bei Liu, Sihui Zhang, Ninghua Huang, Tianshuo Zhao, Qing-Bin Lu, Fuqiang Cui
Summary: This study aims to evaluate the evolution differences in the incidence and case fatality rate of SARS-CoV-2 Delta and Omicron variants. The findings suggest that the Omicron variant has a higher incidence but a lower case fatality rate worldwide, mainly due to the decreased pathogenicity caused by the mutation of the virus, while vaccination still plays a valuable role in preventing death.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Transplantation
Francois Gougeon, Harsharan K. Singh, Volker Nickeleit
Summary: This study analyzed renal comorbidities in collapsing focal segmental glomerulosclerosis (FSGS) and found that collapsing glomerulopathy (CG) has a higher rate of comorbidities compared to tip-variant FSGS (T-FSGS). The study showed that vascular diseases, especially stenosing vasculopathies, were more prevalent in CG with comorbidities. Membranous glomerulopathies were also more common in native kidneys with accompanied CG. These findings are important for understanding the pathogenesis and possible therapeutic strategies for CG.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
