Natural Product Based Antibody Drug Conjugates: Clinical Status as of November 9, 2020

Plant Endophytes and Epiphytes: Burgeoning Sources of Known and “Unknown” Cytotoxic and Antibiotic Agents?

(2020) David J. Newman et al.   PLANTA MEDICA

Heterogeneous Strategies to Eliminate Intracellular Bacterial Pathogens

(2020) Yuan Liu et al.   Frontiers in Microbiology

A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma

(2020) Ricarda M. Hoffmann et al.   Cancers

Advances in Antibody–Drug Conjugate Design: Current Clinical Landscape and Future Innovations

(2020) Laurence Gauzy-Lazo et al.   SLAS Discovery

UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads

(2020) Ilona Pysz et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy

(2020) Hang-Ping Yao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmaceutical strategies in the emerging era of antibody-based biotherapeutics for the treatment of cancers overexpressing MET receptor tyrosine kinase

(2020) Hang-Ping Yao et al.   DRUG DISCOVERY TODAY

A phase 1, randomized, single ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of DSTA4637S, an anti-Staphylococcus aureus THIOMAB™ antibody-antibiotic conjugate, in healthy volunteers

(2019) Melicent Peck et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Near-Infrared Photoimmunotherapy of Cancer

(2019) Hisataka Kobayashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

A landmark in drug discovery based on complex natural product synthesis

(2019) Satoshi Kawano et al.   Scientific Reports

Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577

(2019) Zilong Wang et al.   JOURNAL OF NATURAL PRODUCTS

Novel HER2-Targeting Antibody-Drug Conjugates of Trastuzumab Beyond T-DM1 in Breast Cancer: Trastuzumab Deruxtecan(DS-8201a) and (Vic-)Trastuzumab Duocarmazine (SYD985)

(2019) Zhuyu Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Toward aplyronine payloads for antibody–drug conjugates: total synthesis of aplyronines A and D

(2018) Nika Anžiček et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer

(2018) Xiaofan Li et al.   CANCER RESEARCH

Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells

(2018) Krista Kinneer et al.   LEUKEMIA

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

(2017) Hao Chen et al.   MOLECULES

Abstract 1368: Preclinical evaluation of NC-6201, an antibody/drug-conjugated micelle incorporating novel hemiasterlin analogue E7974

(2016) Mitsunori Harada et al.   CANCER RESEARCH

DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

(2016) Y. Ogitani et al.   CLINICAL CANCER RESEARCH

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

(2016) Renato Pereira et al.   Marine Drugs

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

(2016) Arnaud C. Tiberghien et al.   ACS Medicinal Chemistry Letters

Cross-species biosynthesis of maytansine in Maytenus serrata

(2016) Parijat Kusari et al.   RSC Advances

Endophytes Are Hidden Producers of Maytansine in Putterlickia Roots

(2014) Souvik Kusari et al.   JOURNAL OF NATURAL PRODUCTS

Interactions between Co-Habitating fungi Elicit Synthesis of Taxol from an Endophytic Fungus in Host Taxus Plants

(2013) Sameh S. M. Soliman et al.   Frontiers in Microbiology

Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

(2011) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Antineoplastic Agents. 592. Highly Effective Cancer Cell Growth Inhibitory Structural Modifications of Dolastatin 10

(2011) George R. Pettit et al.   JOURNAL OF NATURAL PRODUCTS

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

(2009) G. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

(2008) Kiyoyuki Yamada et al.   NATURAL PRODUCT REPORTS