Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1225, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2020.129094
Keywords
Zn-based MOFs; Organic-inorganic; Antibacterial activity; Reactive oxygen species
Categories
Funding
- National Natural Science Foundation of Guangdong Province [2017A030310 666, 2018A030307003]
- Guangdong Medical University Nanhai Marine Biomedical Resources R&D Public Service Platform Open Fund Project [2HC18013, 2HC18016]
- Group-type Special Support Project for Education Talents in Universities [4SG19045G]
- Undergraduate Science&Technology Innovation Foundation of Guangdong Province [201810571046, 201810571073]
- Medical Science and Technology Development Foundation of Guangdong Province [A2016355]
- Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University) [sklpme2018-4-23]
- State Key Laboratory of Molecular Engineering of Polymers (Fudan University)
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Zn-based MOFs were successfully synthesized and characterized, showing superior antibacterial activities that might be associated with the generation of reactive oxygen species (ROS).
Zn-based MOFs, [Zn(formato)(2) (4,4'-bipy)] (4,4'-bipy = 4,4'-bipyridine) (1), had been successfully synthesized and characterized by elemental analysis (CHN), single crystal X-ray analysis and Single crystal X-ray diffraction (XRD), thermogravimetric analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). Then, the antimicrobial activities of complex 1 against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were evaluated by measuring growth inhibition curves and the zones of inhibition. The experimental data showed that 1 exhibited superior antibacterial activities in comparison with the zinc ion and the formic acid ligand as well as the 4,4'-bipy ligand, and the mechanism of action might be associated with the generation of reactive oxygen species (ROS). (C) 2020 Elsevier B.V. All rights reserved.
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