Article
Endocrinology & Metabolism
Mathis Grossmann, Channa N. Jayasena, Bradley D. Anawalt
Summary: Although testosterone replacement therapy is commonly used for men with classical hypogonadism, its role in age-related decline of testosterone remains unclear due to limited evidence from long-term clinical trials. However, men aged 50 years and above with comorbidities and higher body mass index often exhibit symptoms of androgen deficiency and low testosterone levels. Clinicians face a challenging dilemma in initiating testosterone therapy and must carefully assess the benefits and risks based on limited clinical trial data. In this article, a practical approach to the assessment and management of such men is presented using a case scenario.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, Research & Experimental
Marcelo Rodrigues dos Santos, Shalender Bhasin
Summary: The increase in life expectancy for men has drawn attention to quality-of-life issues related to reproductive aging. Testosterone levels decline with age and can be improved with treatment, although long-term effects on major cardiovascular events and prostate cancer risk remain unclear.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Endocrinology & Metabolism
Thiberiu Banica, Charlotte Verroken, Tim Reyns, Ahmed Mahmoud, Guy T'Sjoen, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
Summary: This study indicates that serum androgen levels start declining early in adult life, independently from changes in BMI and other lifestyle factors. The decline in androgen levels most likely arises from a primary decrease in testicular function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Andrology
Magaly Aceves-Martins, Richard Quinton, Miriam Brazzelli, Moira Cruickshank, Paul Manson, Jemma Hudson, Nick Oliver, Rodolfo Hernandez, Lorna Aucott, Frederick Wu, Waljit S. Dhillo, Siladitya Bhattacharya, Katie Gillies, Channa N. Jayasena
Summary: Men with male hypogonadism commonly experience sexual dysfunction and other adverse changes, which may be better understood through qualitative data from individual patient experiences. Research on MH is limited to North America and predominantly white participants, highlighting the need for a broader understanding to improve patient information delivery. A patient-centered approach to interactions and a multidisciplinary approach to address symptoms beyond MH and TRT may be beneficial.
Article
Endocrinology & Metabolism
Frederick C. W. Wu
Summary: Diagnosis of functional hypogonadism should lead to a thorough evaluation and optimization of general health, followed by a consideration of testosterone replacement therapy. Testosterone treatment can improve libido, but may not be as effective for erectile dysfunction. It can also have positive effects on insulin resistance, bone strength, physical strength, and mild depressive symptoms, although the long-term clinical significance of these improvements remains uncertain.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bac Nguyen Hoai, Long Hoang, Thang Nguyen Cao, Quan Pham Minh, Emmanuele A. JanninI
Summary: Hypogonadism can have a significant impact on men's physical and psychological health, but diagnosing and treating it in developing countries can be challenging due to lack of awareness, limited resources, and high treatment costs. This review examines the potential benefits and risks of testosterone replacement therapy (TRT) from the perspective of a developing country.
Review
Geriatrics & Gerontology
Ta-Wei Lee, Pei-Yu Kao, Yang-Ching Chen, Sen-Te Wang
Summary: This meta-analysis examined the effects of testosterone replacement therapy (TRT) on muscle strength in older men. The results showed that TRT can significantly improve muscle strength, especially in individuals with relatively low baseline testosterone levels.
Article
Pharmacology & Pharmacy
Sven Stegemann, Viviane Klingmann, Sibylle Reidemeister, Jorg Breitkreutz
Summary: The 6th APV Winter Conference, organized by the APV PaCeMe IN Task Force, was held in Salzburg, Austria from January 19-20, 2023. The conference was dedicated to advancing patient-centric drug development, considering emerging evidence and increasing regulatory requirements.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Endocrinology & Metabolism
Yoann Barnouin, Reina Armamento-Villareal, Alessandra Celli, Bryan Jiang, Arjun Paudyal, Vijay Nambi, Mon S. Bryant, Marco Marcelli, Jose M. Garcia, Clifford Qualls, Dennis T. Villareal
Summary: The study found that adding testosterone to lifestyle therapy for 6 months does not further improve overall physical function in older, obese men with hypogonadism. However, testosterone may help attenuate the reduction in muscle mass and hip bone mineral density caused by weight loss, and may also improve aerobic capacity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Editorial Material
Medicine, General & Internal
Howard Libman, Marc L. Cohen, Michael S. Irwig, Gerald W. Smetana
Summary: Male hypogonadism is characterized by abnormally low serum testosterone concentration or sperm count. As men age, their serum testosterone levels may decrease, and normalizing these levels could improve symptoms related to androgen deficiency.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten, Brian L. Stauffer, Kerry L. Hildreth, Robert S. Schwartz, Wendy M. Kohrt, Kerrie L. Moreau
Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Lauren C. Chasland, Louise H. Naylor, Bu B. Yeap, Andrew J. Maiorana, Daniel J. Green
Summary: Exercise training improves endothelium-dependent vasodilator function in middle-to-older-aged men with central adiposity and low/normal testosterone levels, while administration of testosterone at therapeutic doses does not directly impact vascular function and does not add to the benefits of exercise.
Review
Andrology
Vassilios Papadopoulos, Lu Li, Mary Samplaski
Summary: Recent epidemiological data suggest a gender predisposition to COVID-19, with older men being most severely affected and at higher risk of death. Low testosterone levels may exacerbate the severity of COVID-19 infection in elderly men, while normal levels might offer protection. Additional testing for gonadal function and testosterone treatment may be warranted in elderly males to reduce mortality related to COVID-19.
Article
Geriatrics & Gerontology
Panagiotis Giannos, Konstantinos Prokopidis, David D. Church, Ben Kirk, Paul T. Morgan, Mary Ni Lochlainn, Helen Macpherson, David R. Woods, Theocharis Ispoglou
Summary: This study found a significant positive association between calculated bioavailable testosterone and processing speed, sustained attention, and working memory in older men above 60 years of age.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Geriatrics & Gerontology
Nicholas Fuggle, Nathalie Bere, Olivier Bruyere, Mario Manuel Rosa, Maria Concepcion Prieto Yerro, Elaine Dennison, Fitnat Dincer, Cem Gabay, Ida K. Haugen, Gabriel Herrero-Beaumont, Mickael Hiligsmann, Marc C. Hochberg, Andrea Laslop, Radmila Matijevic, Emmanuel Maheu, Alberto Migliore, Jean-Pierre Pelletier, Regis Pierre Radermecker, Francois Rannou, Brigitte Uebelhart, Daniel Uebelhart, Nicola Veronese, Mila Vlaskovska, Rene Rizzoli, Ali Mobasheri, Cyrus Cooper, Jean-Yves Reginster
Summary: Hand osteoarthritis is a common joint condition, and it is important to address patients' concerns and expectations. In 2019, the ACR/AF released guidelines for the treatment of hand osteoarthritis. The ESCEO expert working group assessed the appropriateness of these guidelines for European patients and emphasized the importance of patient preferences in consultations, research, and policy-making.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
