Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Galecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Summary: This study examines the association between the reoccurrence of illness (ROI), the phenome of depression, and major dysmood disorder (MDMD) features and immune response in major depressive disorder and a major depressive episode (MDD/MDE). The results show that MDMD is characterized by heightened immune responses, which are a consequence of ROI-associated sensitization combined with immunostimulatory triggers.
Article
Health Care Sciences & Services
Michael Maes
Summary: This paper discusses the use of machine learning in depression research and the development of precision psychiatry. Precision psychiatry aims to customize the best medical treatments based on individual's genomics, environmental, and lifestyle data. The paper outlines three steps in the development of precision medicine and highlights the challenges in developing precision psychiatry.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Medicinal
Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Atapol Sughondhabirom, Kitiporn Plaimas, Apichat Suratanee, Michael Maes
Summary: This study examines the effects of cannabidiol (CBD) on the immune-inflammatory response and immune-regulatory system in patients with depression and healthy controls. The results suggest that higher concentrations of CBD may worsen inflammatory processes.
Article
Endocrinology & Metabolism
Michael Maes, Juliana Brum Moraes, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, Heber Odebrecht Vargas, Ana Paula Michelin, Sandra Odebrecht Vargas Nunes
Summary: This study utilized machine learning techniques to construct a model incorporating risk/resilience, adverse outcome pathways, staging, and phenome of mood disorders. By analyzing factors influencing these features, two distinct patient clusters were identified, and a transdiagnostic model of mood disorders was successfully created.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Hawraa Kadhem Al-Jassas, Hussein Kadhem Al-Hakeim, Michael Maes
Summary: This study aims to investigate the associations between affective and chronic fatigue syndrome-like symptoms and chest CT scan anomalies, oxygen saturation, inflammatory biomarkers, etc. in COVID-19 patients. The results showed that the immune response core was associated with lung lesions and affective and physiosomatic symptoms. The infection-immune-inflammatory core plays a significant role in pneumonia-associated CT scan anomalies, decreased oxygen saturation, and immune activation, and it affects the affective and neuropsychiatric symptoms of patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, Estefania Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes
Summary: The study found significant associations between nitro-oxidative stress toxicity, inflammatory pathways, atherogenicity, and mood disorders, especially in patients with mood disorders. Activated oxidative stress pathways play an important predictive role in increased blood pressure, especially through increased lipid peroxidation and protein oxidation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Nikolay Mehterov, Danail Minchev, Maria Gevezova, Victoria Sarafian, Michael Maes
Summary: The reciprocal associations between brain-derived neurotrophic factor (BDNF) and immune-inflammatory pathways are explored in this review, shedding light on the involvement of BDNF in the immune pathophysiology of mood disorders and schizophrenia. The protein-protein interaction (PPI) network centered around BDNF and its interactions with neurotrophic, immune, and cell-cell junction proteins are delineated. BDNF participates in the immune response and may have a protective role against neurotoxicity caused by immune activation and hyperinflammation through its interactions with neuroprotective and cell-cell adhesion proteins.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Hasan Najah Smesam, Hasan Abbas Qazmooz, Sinan Qayes Khayoon, Abbas F. Almulla, Hussein Kadhem Al-Hakeim, Michael Maes
Summary: Rheumatoid arthritis (RA) is associated with depressive and anxiety symptoms as well as chronic fatigue syndrome (CFS)-like symptoms. This study found significant correlations between depressive symptoms, CFS-like symptoms, anxiety scores, and the severity of RA. Immune-inflammatory pathways, autoantibodies, and specific biomarkers play a crucial role in the manifestation of psychiatric symptoms in RA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Andrea Ballesio, Andrea Zagaria, Cristina Ottaviani, Andrew Steptoe, Caterina Lombardo
Summary: This study aimed to investigate the long-term relationship between subjective sleep disturbance and depressive symptoms in older adults. The results showed that sleep disturbance was associated with depressive symptoms in the long-term, and this association was partially mediated by inflammation markers (hs-CRP) in women. These findings provide new insights into the relationship between sleep and depressive symptoms.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Psychiatry
Michael H. J. Maes, Drozdstoy Stoyanov
Summary: The current understanding of major depressive disorder (MDD) and bipolar disorder (BD) is riddled with controversies, but a new, data-driven machine learning method called nomothetic network psychiatry (NNP) provides a new direction for research.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Hussein Kadhem Al-Hakeim, Tabarek Hadi Al-Naqeeb, Abbas F. Almulla, Michael Maes
Summary: This study found that peripheral indicators of neuroaxis damage in MDD were associated with serum inflammatory and insulin resistance markers, calcium, and the physio-affective phenome. CRP and HOMA2-IR predicted 28.9% of the variance in the neuroaxis index. Peripheral inflammation and insulin resistance may damage astroglial and neuronal projections, interfering with mitochondrial transport and contributing to the phenome of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Atapol Sughondhabirom
Summary: Major depressive disorder (MDD) and its severe subtype, major dysmood disorder (MDMD), are characterized by activation of inflammatory and growth factor subnetworks, which are associated with illness recurrence and adverse childhood experiences. Nerve growth factor (NGF) plays a crucial role in neuro-immune communication and may regulate inflammation. The study found that NGF levels are lower in MDD, especially MDMD, compared to normal controls.
Review
Clinical Neurology
Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Michael Maes
Summary: This meta-analysis identified increased immune activation, inflammation, neurotoxicity, and decreased neuroprotection in patients with suicide attempts compared to healthy controls and patients with fewer suicide attempts.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, Research & Experimental
Junliang Jiang, Miaoxian Yang, Mi Tian, Zhong Chen, Lei Xiao, Ye Gong
Summary: Major depressive disorder (MDD) is a prevalent psychiatric disorder, and the COVID-19 pandemic has worsened its prevalence. Oxytocin, an endogenous neuropeptide, has emerged as a potential therapeutic option due to its anxiolytic and antidepressant properties. This review examines the interactions between oxytocin, the immune system, and depressive disorder, and speculates on the potential roles of oxytocin and the central immune system in treating emotional disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Abbas F. F. Almulla, Dhurgham Shihab Al-Hadrawi, Michael Maes
Summary: This study investigates the association between body temperature and oxygen saturation during the acute phase of COVID-19 and the long-term physio-affective symptoms. It demonstrates that the severity of long COVID symptoms can be predicted by a neurotoxicity index, low calcium levels, peak body temperature and oxygen saturation during the acute phase, and prior vaccinations. The most important predictors of the physio-affective symptoms are calcium, C-reactive protein, interleukin-1 beta, advanced oxidation protein products, and myeloperoxidase.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Halah Nori Asad, Hussein Kadhem Al-Hakeim, Shatha Rouf Moustafa, Michael Maes
Summary: This study aimed to investigate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/β-catenin pathway in ESRD patients. The results showed that ESRD patients exhibit high levels of fatigue and physio-somatic symptoms, which are associated with dialysis-induced changes in inflammatory pathways, the Wnt/β-catenin pathway, and copper levels.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Medicine, Research & Experimental
Shatha Rouf Moustafa, Hussein Kadhem Al-Hakeim, Zainab Hussein Alhillawi, Michael Maes
Summary: The study examines the associations between low a-Klotho status and calcium metabolism in children with TDT in relation to iron status. It found that a significant number of TDT patients had lowered levels of a-Klotho, which were associated with decreased serum total and ionized calcium concentrations. TDT patients also showed imbalanced hormone and mineral levels compared to healthy children.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Dhurgham Shihab Al-Hadrawi, Abbas F. Almulla, Michael Maes
Summary: The immune-inflammatory response during the acute phase of COVID-19 predicts the severity of chronic fatigue, depression, and anxiety symptoms in Long COVID. SpO2 and PBT during acute infection affect immune and oxidative stress pathways in Long COVID.
MOLECULAR PSYCHIATRY
(2023)
Letter
Clinical Neurology
Abbas F. Almulla, Hussein Kadhem Al-Hakeim, Michael Maes
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Xia Qiu, Yin Wu, Ying Sun, Brooke Levis, Jizhou Tian, Jill T. Boruff, Pim Cuijpers, John P. A. Ioannidis, Sarah Markham, Roy C. Ziegelstein, Simone N. Vigod, Andrea Benedetti, Brett Thombs, Chen He, Ankur Krishnan, Parash Mani Bhandari, Dipika Neupane, Zelalem Negeri, Mahrukh Imran, Danielle B. Rice, Marleine Azar, Matthew J. Chiovitti, Simon A. Gilbody, Lorie B. Kloda, Scott D. Patten, Nicholas Mitchell, Ruben Alvarado, Jacqueline Barnes, Cheryl Tatano Beck, Carola Bindt, Humberto Correa, Tiago Castro e Couto, Genesis Chorwe-Sungani, Valsamma Eapen, Nicolas Favez, Ethel Felice, Gracia Fellmeth, Michelle Fernandes, Sally Field, Barbara Figueiredo, Jane R. W. Fisher, Eric P. Green, Simone Honikman, Louise M. Howard, Pirjo A. Kettunen, Jane Kohlhoff, Zoltan Kozinszky, Angeliki A. Leonardou, Michael Maes, Pablo Martinez, Sandra Nakic Rados, Daisuke Nishi, Susan J. Pawlby, Tamsen J. Rochat, Heather J. Rowe, Deborah J. Sharp, Alkistis Skalkidou, Johanne Smith-Nielsen, Alan Stein, Kuan-Pin Su, Inger Sundstroem-Poromaa, Meri Tadinac, S. Darius Tandon, Iva Tendais, Annamaria D. Toereki, Thach Tran, Kylee Trevillion, Katherine S. Turner, Mette Vaever, Thandi M. van Heyningen, Johann Vega-Dienstmaier, Karen A. Wynter, Kimberly Yonkers
Summary: Item 10 of the EPDS assesses self-harm thoughts but may also elicit concerns about accidental self-harm. The EPDS-9, which omits item 10, is sometimes used in research due to concerns about its implications. A meta-analysis of individual participant data showed that EPDS-9 performs similarly to the full EPDS in detecting major depression among pregnant and postpartum women.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hussein Kadhem Al-Hakeim, Anwar Khairi Abed, Shatha Rouf Moustafa, Abbas F. Almulla, Michael Maes
Summary: In this study, we found that severe Long COVID patients had low serum tryptophan, low oxygen saturation, high insulin resistance, high C-reactive protein, and high ratings on all symptom domains. Inflammatory responses, decreased tryptophan, and increased kynurenine may contribute to the physio-affective phenome of Long COVID.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Psychiatry
Ketsupar Jirakran, Asara Vasupanrajit, Chavit Tunvirachaisakul, Michael Maes
Summary: This study aimed to determine whether neuroticism is a feature of the acute state of major depressive disorder (MDD), including suicidal behaviors, and whether adverse childhood experiences are associated with neuroticism in MDD. The results showed that neuroticism was significantly higher in MDD patients compared to healthy controls, and it explained a large portion of the variance in the depression phenome. Neglect and abuse in childhood accounted for a significant portion of the variance in the latent vector representing MDD phenome, with neuroticism partially mediating the effects of neglect and completely mediating the effects of abuse.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Rosa Savino, Alessandro Medoro, Sawan Ali, Giovanni Scapagnini, Michael Maes, Sergio Davinelli
Summary: While autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome, studies have shown that oxidative stress and inflammation are common factors in ASD. Flavonoids, plant-derived compounds with antioxidant, anti-inflammatory, and neuroprotective effects, have been investigated for their potential impact on ASD. A review of preclinical and clinical studies found that flavonoids may improve oxidative stress parameters, reduce inflammation, and ameliorate core symptoms of ASD. However, more randomized placebo-controlled trials are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
George Anderson, Abbas F. Almulla, Russel J. Reiter, Michael Maes
Summary: There is increasing evidence that autoimmune processes play an important role in various medical conditions, including cancers, neurodegenerative diseases, and psychiatric disorders. These conditions are associated with alterations in mitochondrial function across cells. The mitochondrial melatonergic pathway is present in all body cells and has important implications for driving autoimmune processes.
Article
Cell Biology
Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Sunchai Payungporn
Summary: Maes et al. (2008) found that major depressive disorder (MDD) is associated with abnormalities in the microbiota-gut-brain axis, characterized by elevated IgM/IgA levels to lipopolysaccharides (LPS) from Gram-negative bacteria. In a study of Thai patients with MDD, fecal samples were analyzed using 16S rDNA sequencing. The results showed a specific profile of gut dysbiosis in MDD, with increased pathobionts and depleted beneficial microbiota, suggesting a potential biomarker of MDD.
Article
Psychiatry
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Abdulsahib S. Jubran, Abbas F. Almulla, Shatha Rouf Moustafa, Michael Maes
Summary: This study examined the association between long COVID and increased insulin resistance, as well as its connection with neuroimmune and oxidative processes. The results showed that long COVID patients had increased insulin resistance, which was associated with depressive symptoms.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Basim Abd Al-Raheem Twaij, Hussein Kadhem Al-Hakeim, Mazin Fadhil Altufaili
Summary: Many studies have observed toxic effects on neuronal integrity in end-stage renal disease (ESRD) patients, both in the short and long term, highlighting the need for a better understanding of the mechanisms and potential treatments through the study of chemical molecules causing tissue damage to neurons.
JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
(2023)
Letter
Psychiatry
Michael Maes, Abbas F. Almulla, Hussein Kadhem Al-Hakeim
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Michael Maes, Paul Thisayakorn, Yanin Thipakorn, Saran Tantavisut, Sunee Sirivichayakul, Aristo Vojdani
Summary: This study found that elevated IgA levels against neuronal self-antigens, AQP4, and HSP60 are risk factors for delirium. The breakdown of immune tolerance, activation of the immune-inflammatory response system, and injuries in neuronal and glial cells are involved in the pathophysiology of delirium.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)