Article
Oncology
Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng, Gaosong Wu
Summary: ALND based on BLL can minimize surgical extent for node-positive breast cancer patients, potentially reducing the occurrence of BCRL.
Article
Oncology
Massimiliano Gennaro, Chiara Listorti, Luigi Mariani, Marco Maccauro, Giulia Bianchi, Giuseppe Capri, Ilaria Maugeri, Laura Lozza, Maria Carmen De Santis, Secondo Folli
Summary: In this study, we followed up on 100 consecutive axillary node-positive patients treated with ARM-SAD and found a low rate of axillary failure, indicating that the ARM-SAD procedure is oncologically safe.
Article
Oncology
Margaret L. McNeely, Naomi D. Dolgoy, Bolette Skjodt Rafn, Sunita Ghosh, Paula A. Ospina, Mona M. Al Onazi, Lori Radke, Mara Shular, Urve Kuusk, Marc Webster, Kristin L. Campbell, John R. Mackey
Summary: This study found that adding nighttime compression to the treatment of chronic breast cancer-related lymphedema, whether through self-applied compression bandaging or through the use of a nighttime compression system garment, significantly improved excess arm volume and quality of life. Nighttime compression was shown to be an effective self-management strategy for women with chronic breast cancer-related lymphedema.
Article
Surgery
Prerna Dehariya, Namrata Agarwal, Sanjay Kumar Yadav, Pawan Agarwal, Dhananjaya Sharma
Summary: In this study, we evaluated the impact of topical epinephrine with xylocaine on drainage after axillary lymph node dissection. The results showed that the total drainage volume and duration of drainage were significantly decreased in the epinephrine with xylocaine group compared to the conventional drainage group. The incidence of seroma formation and wound infection was similar in both groups.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Manuel Algara, Elvira Rodriguez, Francisco Jose Martinez-Arcelus, Juan Salinas, Xavier Sanz, Inmaculada Beato, Aurea Manso, Ana Soler, Jose Reyes Rodriguez, Andere Frias, Ana Calin, German Juan, Pedro Meireles, Amanda Flaquer
Summary: This study compared the efficacy of incidental irradiation and intentional irradiation in breast cancer patients with fewer involved lymph nodes. The results showed that incidental irradiation is non-inferior to intentional irradiation in terms of 5-year disease-free survival, locoregional recurrence, and distant recurrence.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Rehabilitation
Riikka Lampinen, Jeannette Q. Lee, Janella Leano, Christine Miaskowski, Judy Mastick, Lisa Brinker, Kimberly Topp, Betty Smoot
Summary: In this study comparing negative pressure massage treatment (NPMT) with manual lymphatic drainage (MLD) in women with chronic breast cancer-related lymphedema, NPMT demonstrated greater improvements in lymphedema index and limb volume compared to MLD. However, differences in Disabilities of the Arm, Shoulder, and Hand questionnaire scores were not statistically significant.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Oncology
Qianqian Yuan, Jinxuan Hou, Rui Zhou, Lewei Zheng, Fang Lu, Tong Deng, Wenbo Zhou, Gaosong Wu
Summary: This study aimed to demonstrate the feasibility of axillary dissection of lymph nodes from the breast (bALND) for reducing the extent of surgery in node-positive breast cancer patients. Results showed that in the bALND group, lymphatic vessels and subsequent-echelon lymph nodes from the breast were stained blue after injection of methylene blue, and a majority of patients had fewer than four metastatic nodes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Gilles Houvenaeghel, Monique Cohen, Pedro Raro, Jeremy De Troyer, Pierre Gimbergues, Christine Tunon de Lara, Vivien Ceccato, Veronique Vaini-Cowen, Christelle Faure-Virelizier, Frederic Marchal, Tristan Gauthier, Eva Jouve, Pierrick Theret, Claudia Regis, Philippe Gabelle, Julia Pernaut, Francesco Del Piano, Gauthier D'Halluin, Stephane Lantheaume, Emile Darai, Bassoodeo Beedassy, Caroline Dhainaut-Speyer, Xavier Martin, Sophie Girard, Richard Villet, Emilie Monrigal, Theophile Hoyek, Jean-Francois Le Brun, Pierre-Emmanuel Colombo, Agnes Tallet, Jean-Marie Boher
Summary: The study analyzed the treatment and pathological results of patients included in the SERC trial, a multicenter randomized non-inferiority phase-3 trial comparing completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy alone in breast cancer patients. Patients with one or two involved sentinel nodes by micro- or macro-metastases may not require cALND, but further research is needed for those with more than two involved nodes.
Article
Medicine, General & Internal
Kelsey Lipman, Anna Luan, Kimberly Stone, Irene Wapnir, Mardi Karin, Dung Nguyen
Summary: This study highlights the LYMPHA technique as a feasible and effective method for prevention of lymphedema. By performing lymphatic mapping and lymphaticovenous anastomosis during the primary surgery, the morbidity associated with lymphedema can be avoided. A retrospective review showed successful prevention of lymphedema with minimal surgical complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hope M. Guzzo, Stephanie A. Valente, Graham S. Schwarz, Ayat ElSherif, Stephen R. Grobmyer, Cagri Cakmakoglu, Risal Djohan, Steven Bernard, Julie E. Lang, Debra Pratt, Zahraa Al-Hilli
Summary: The study evaluated the safety and recurrence rates of immediate lymphatic reconstruction (ILR) in breast cancer patients undergoing axillary lymph node dissection (ALND). The results showed that ILR during ALND was not associated with short-term axillary recurrence and appeared to be oncologically safe.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Fabio Sandrin, Luiz Felipe Nevola Teixeira, Manfredi Garavaglia, Sara Gandini, Maria Claudia Simoncini, Alberto Luini
Summary: The study aimed to evaluate the effectiveness of a manual snapping maneuver in increasing ROM during abduction compared to a standard stretching exercise. A three-year follow-up was conducted to determine the incidence of Breast Cancer-Related Lymphedema. The results showed that adding the manual snapping maneuver to the stretching exercise did not improve patient outcomes and was not associated with lymphedema during the three-year follow-up.
Article
Medicine, General & Internal
Jesus Baltasar Gonzalez Rubino, Maria Jesus Vinolo-Gil, Cristina Garcia Munoz, Rocio Martin-Valero
Summary: Breast cancer is the most common malignant tumor in women, and post-mastectomy lymphedema and axillary web syndrome are common surgical sequelae that affect patient functionality and treatment time.
Article
Cardiac & Cardiovascular Systems
Avi Sabbag, Anat Berkovich, Ehud Raanani, David Volvovitch, William F. McIntyre, Yigal Kassif, Alexander Kogan, Michael Glikson, Roy Beinart
Summary: Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery, associated with increased mortality and thrombo-embolism. The rates of recurrence and optimal management remain unclear. This study aimed to evaluate the incidence of recurrent atrial fibrillation in patients with POAF following cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Massimiliano Gennaro, Marco Maccauro, Luigi Mariani, Chiara Listorti, Carmela Sigari, Annarita De Vivo, Marco Chisari, Ilaria Maugeri, Alice Lorenzoni, Gianluca Aliberti, Gianfranco P. Scaperrotta, Augusto Caraceni, Giancarlo Pruneri, Secondo Folli
Summary: This study confirms that axillary reverse mapping and selective axillary dissection (ARM-SAD) can reduce the risk of breast-cancer-related lymphedema (BCRL) in patients with node-positive breast cancer, compared to standard axillary dissection (AD). ARM-SAD showed significantly lower incidence of BCRL in multiple assessments, including physiatrist's findings, excess arm volume, and lymphoscintigraphic findings, although there was no significant difference in patients' self-reports.
Article
Oncology
Sheila H. Ridner, Mary S. Dietrich, Jie Deng, Sandra L. Ettema, Barbara Murphy
Summary: This trial demonstrates the safety and feasibility of using APCD in head and neck cancer patients with lymphedema, with preliminary data suggesting efficacy.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Joseph Do Woong Choi, T. Michael D. Hughes, Gavin Marx, John Boyages, Josie Rutovitz, Csilla Hasovits, Andrew Parasyn, Senarath Edirimanne, Nicholas K. Ngui
Summary: This study uses the Oncotype DX assay to evaluate the recurrence risk in breast cancer patients and finds that patients with low and intermediate recurrence scores rarely receive chemotherapy, while patients with high recurrence scores always receive chemotherapy. This prescribing pattern is associated with a low rate of distant recurrence.
Article
Medicine, Research & Experimental
Leigh C. Ward, Louise A. Koelmeyer, Emma Moloney
Summary: This study explored the utility of bioelectrical impedance parameters in staging breast cancer-related lymphedema through hierarchical agglomerative cluster analysis. The cluster analysis of impedance data could potentially serve as a useful adjunct objective assessment for staging lymphedema by grouping patients with similar impedance characteristics.
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sheila H. Ridner, Mary S. Dietrich, John Boyages, Louise Koelmeyer, Elisabeth Elder, T. Michael Hughes, James French, Nicholas Ngui, Jeremy Hsu, Vandana G. Abramson, Andrew Moore, Chirag Shah
Summary: This study found that compared to tape measurement, bioimpedance spectroscopy provides a more precise identification of patients likely to benefit from an early compression intervention.
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Article
Oncology
Louise A. Koelmeyer, Katrina Gaitatzis, Mary S. Dietrich, Chirag S. Shah, John Boyages, Sarah A. McLaughlin, Bret Taback, Deonni P. Stolldorf, Elisabeth Elder, T. Michael Hughes, James R. French, Nicholas Ngui, Jeremy M. Hsu, Andrew Moore, Sheila H. Ridner
Summary: The study aimed to evaluate risk factors for breast cancer-related lymphedema (BCRL) and found that factors associated with this condition included axillary lymph node dissection, taxane-based chemotherapy, regional nodal irradiation, body mass index >30, and rurality. The findings of this study are important for the treatment and intervention of breast cancer patients.
Article
Surgery
Hiroo Suami, Belinda Thompson, Helen Mackie, Robbie Blackwell, Asha Heydon-White, Fiona Tisdall Blake, John Boyages, Louise Koelmeyer
Summary: Using a combination of ICG lymphography and ICG-guided manual lymphatic drainage, this study conducted diagnostic assessment of lower limb lymphoedema. Eight drainage regions were identified, including two original regions and six compensatory regions. Differences in drainage patterns were observed among different types of lymphoedema.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Mary S. Dietrich, Katrina Gaitatzis, Louise Koelmeyer, John Boyages, Vandana G. Abramson, Sarah A. McLaughlin, Nicholas Ngui, Elisabeth Elder, James French, Jeremy Hsu, T. Michael Hughes, Deonni P. Stolldorf, Chirag Shah, Sheila H. Ridner
Summary: A compression intervention for subclinical breast cancer-related lymphedema led to improvements in physical, emotional, and quality-of-life outcomes. The study found that greater changes in extracellular fluid and whole-arm volume were associated with higher symptom, skin condition, and quality-of-life values in patients with S-BCRL. Prospective surveillance and compression interventions were effective in reducing progression rates from S-BCRL to C-BCRL.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Surgery
Helen Mackie, Hiroo Suami, Belinda M. Thompson, Quan Ngo, Asha Heydon-White, Robbie Blackwell, Louise A. Koelmeyer
Summary: This study used indocyanine green (ICG) lymphography to investigate retrograde lymph flow in patients with lymphedema. The findings contradicted the conventional understanding of lymphedema pathology, as retrograde lymph flow was rare and not necessarily related to disease progression. Instead, it may be associated with toxic or asymptomatic lymphangitis. These findings have implications for conservative management and lymphovenous anastomosis surgery.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Oncology
Helen Mackie, Belinda M. Thompson, Louise A. Koelmeyer, Robbie Blackwell, Katrina Gaitatzis, Asha Heydon-White, John Boyages, Hiroo Suami
Summary: This study used ICG lymphography to determine that 16.9% of patients with lower-limb lymphedema have a compensatory lymphatic drainage pathway from the affected limb to the contralateral inguinal lymph node region, particularly observed in unilateral cancer-related lymphedema with edema in the proximal thigh, inguinal, pubic, and lower abdominal regions. Directing manual lymphatic drainage to the contralateral inguinal drainage region should be considered especially for patients with cancer-related LLLE.
REHABILITATION ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Helen Mackie, Belinda Thompson, Asha Heydon-White, Hiroo Suami, Robbie Blackwell, Louise Koelmeyer
Summary: This study used ICG lymphography to investigate the presence of the axillo-inguinal lymphatic drainage pathway in patients with upper and lower extremity lymphedema. The findings suggest that this pathway is not present in upper extremity lymphedema patients and is rare in lower extremity lymphedema patients.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Helen Mackie, Belinda M. Thompson, Hiroo Suami, Asha Heydon-White, Robbie Blackwell, Fiona Tisdall Blake, Louise A. Koelmeyer
Summary: This study used indocyanine green (ICG) lymphography to assess the presence or absence of lymphoedema in the lower limbs of women with lipoedema. The findings suggested that the clear majority of patients did not exhibit symptoms of lymphoedema.
Article
Surgery
T. Karlsson, H. Mackie, K. Ho-Shon, R. Blackwell, A. Heydon-White, L. Koelmeyer, H. Suami
Summary: Using both ICG lymphography and MRI, this study found that 10 out of 28 patients with unilateral advanced cancer-related lower extremity lymphoedema (LEL) exhibited gluteal lymphoedema. Compared to the non-gluteal lymphoedema group, patients in the gluteal lymphoedema group showed thickened skin and increased gluteal subcutaneous tissue on ICG lymphography, with no significant difference in excess leg volume between the two groups. The severity of gluteal lymphoedema was positively correlated with excess leg volume on the affected side. In conclusion, surgical and conservative management options should be considered for advanced LEL patients.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Oncology
Cheryl L. Brunelle, John Boyages, Amanda W. Jung, Hiroo Suami, Brooke C. Juhel, Asha Heydon-White, Helen Mackie, Shinn-Huey Shirley Chou, Vincent S. Paramanandam, Louise Koelmeyer, Alphonse G. Taghian
Summary: The diagnosis and treatment of breast lymphedema (BL) after breast-conserving surgery lacks standardized criteria and high-quality studies. There is variability in the incidence, time course, and risk factors for BL. Tissue dielectric constant and ultrasound are emerging as promising assessment tools, but further validation and research are needed.
BREAST CANCER RESEARCH AND TREATMENT
(2023)