Article
Biochemistry & Molecular Biology
H. -Y. Ma, Y. -Y. Li, L. Li, Y. Tan, B. -P. Pang
Summary: The study discovered that topical application of the JH analogue methoprene induced the expression of GdMet in 3-day-old and 5-day-old adults of Galeruca daurica. Silencing GdMet through RNAi inhibited the expression of JHBP, JHE, Kr-h1, and Vg, while promoting FAS2 expression, leading to enhanced lipid accumulation and fat body development, ultimately inducing the adults into diapause ahead of schedule.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meng-Meng Chang, Yan-Hong Wang, Qing-Tai Yang, Xue-Li Wang, Mao Wang, Alexander S. Raikhel, Zhen Zou
Summary: The study reveals the negative impact of juvenile hormone on the expression of immunity-related genes in female mosquitoes. It further demonstrates the important role of juvenile hormone in regulating mosquito immune responses. The findings suggest that juvenile hormone suppresses antimicrobial peptide gene expression through its receptor Met, while PGRP-LC activates this gene, indicating dual regulation by both the juvenile hormone and IMD signaling pathways.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Sun-Hyung Lim, Da-Hye Kim, Jae-A. Jung, Jong-Yeol Lee
Summary: The study found that the alternative splicing of CmbHLH2 plays a key role in regulating the color changes of chrysanthemum ray florets. The shorter splicing variant CmbHLH2(Short) failed to activate anthocyanin biosynthetic genes and induce pigment accumulation, while the full-length form CmbHLH2(Full) promoted these processes when co-expressed with CmMYB6.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Entomology
Qiao Gao, Bei Li, Bing-Xin Wei, Wen Liu, Pan Wang, Jia-Lu Wang, Xing-Miao Zhou, Xiao-Ping Wang
Summary: This study revealed that photoperiod regulates male IRS development in H. axyridis through a conserved Met-dependent JH signaling pathway. The results indicate the importance of JH in IRS development and how Met knockdown can affect this process in male ladybeetles.
Review
Biochemistry & Molecular Biology
Yaqi Hao, Xiumei Zong, Pan Ren, Yuqi Qian, Aigen Fu
Summary: The bHLH transcription factor family in plants is involved in regulating various physiological processes such as biosynthesis, metabolism, and plant hormone signaling by forming dimers. They play important roles in plant growth and development, stress responses, and signaling networks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Entomology
Jie Zhang, Mengyao Zhu, Qilin Li, Ting Tang, Liang Wen, Jielai Zhong, Ruonan Zhang, Xiao-Qiang Yu, Yuzhen Lu
Summary: bHLH transcription factors play crucial roles in various metabolic and developmental processes in eukaryotes, and this study investigated their response to different pathogens in the polyphagous insect, Spodoptera litura. The research identified a new bHLH gene specific to Lepidoptera, analyzed the expression profiles of bHLH genes in response to pathogens, and highlighted the downregulation of SlbHLHs in the midgut of S. litura larvae after Bacillus thuringiensis treatment. These findings provide insights into the host-pathogen interaction mechanism mediated by bHLH members.
Article
Physiology
Anita T. Layton, Michelle L. Gumz
Summary: The study investigated the influence of sex and circadian clock on mouse kidney function by developing computational models. It found differences in water and Na+ reabsorption along different nephron segments and sex-specific effects on Na+ channel activity, potentially leading to blood pressure reduction in males.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bin-Bin Yang, Shi-Yuan Miao, Yu-Jie Lu, Sui-Sui Wang, Zheng-Yan Wang, Ya-Ru Zhao
Summary: In this study, the roles of Methoprene-tolerant (Met) and Kruppel-homolog 1 (Kr-h1) in the reproduction of Liposcelis entomophila were investigated. Knockdown of Met and Kr-h1 resulted in decreased vitellogenesis and ovarian development, leading to a decline in fecundity. Moreover, the expression of other hormone factors, such as FoxO, was also affected. These findings highlight the importance of JH signaling in female reproduction of psocids and suggest that RNAi-mediated knockdown of Met or Kr-h1 could be a potential pest control strategy.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Parasitology
Maura Rojas-Pirela, Andrea Delgado, Yossmayer d. C. Rondon-Guerrero, Ana J. Caceres, Paul A. M. Michels, Juan Luis Concepcion, Wilfredo Quinones
Summary: PAS domains are a family of domains present in various prokaryotic and eukaryotic organisms. In Trypanosoma cruzi, the phosphoglycerate kinase (PGK) isoform TcPAS-PGK, which contains a PAS domain, was found to be localized in glycosomes and enriched mitochondrial fraction. The PAS domain plays an important regulatory role in the catalytic activity of PGK in T. cruzi.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Edmundo Gassias, Annick Maria, Philippe Couzi, Elodie Demondion, Nicolas Durand, Francoise Bozzolan, Paleo Aguilar, Stephane Debernard
Summary: This study investigates the effects of juvenile hormone on the development and secretory activity of the accessory glands in Agrotis ipsilon, revealing the crucial role of the JH-Met-Kr-h1 signaling pathway in this process.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Neurosciences
Kaja Nurm, Mari Sepp, Carla Castany-Pladevall, Jordi Creus-Muncunill, Jurgen Tuvikene, Alex Sirp, Hanna Vihma, Derek J. Blake, Esther Perez-Navarro, Tonis Timmusk
Summary: Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by motor symptoms appearing in midlife, and research suggests that isoform-specific changes in TCF4 expression in HD may contribute to progressive impairment of transcriptional regulation and neuronal function in the disease.
Article
Plant Sciences
Xueying Chen, Yao-Qian Liu, Man-Ni Wu, Lei Yan, Chun-Yu Chen, Yu-Pei Mu, Yu-Jie Liu, Mu-Yang Wang, Xiao-Ya Chen, Ying-Bo Mao
Summary: The venom-like proteins in caterpillar oral secretion interfere with plant defense by binding to transcription factors, making plants more susceptible to herbivory.
Article
Biochemistry & Molecular Biology
Sayoko Ito-Harashima, Mai Matsuura, Eiji Takada, Masanobu Kawanishi, Yoshiaki Nakagawa, Takashi Yagi
Summary: Juvenile hormones (JHs) play crucial roles in insect growth, metamorphosis, and reproduction, with synthetic JH agonists (JHAs) being used as insecticides. Both natural JHs and synthetic JHAs bind to the JH receptor Met, inducing the transcription of JH response genes. A new yeast reporter gene assay (RGA) has been established for detecting various juvenoid ligands in a dose-dependent manner, showing correlation with RGAs established in mammalian and insect cells.
Article
Biochemical Research Methods
Kyungbo Kim, Najla M. Albishi, Subba Reddy Palli
Summary: Recent studies have shown that JH-induced changes in the phosphorylation profiles of AaMet and AaKr-h1 contribute to their transcriptional activity. JH activation leads to alterations in the phosphorylation profiles of multiple residues of AaMet, while dephosphorylation of AaKr-h1 at phosphoserine-694 increases its transcriptional activity. These findings provide insights into how JH modulates key transcription factors and could aid in the development of novel insect control strategies.
JOURNAL OF PROTEOMICS
(2021)
Review
Behavioral Sciences
Paleo Aguilar, Thomas Bourgeois, Annick Maria, Philippe Couzi, Elodie Demondion, Francoise Bozzolan, Edmundo Gassias, Evan Force, Stephane Debernard
Summary: In insects, juvenile hormone (JH) plays a critical role in the development of male reproductive behavior. The expression of JH receptors and JH-inducible transcription factor within the primary olfactory centers correlates with the behavioral responsiveness to sex pheromone. JH acts through the Met-Kr-h1 signaling pathway to promote the processing of pheromone information and the display of sexual behavior in synchronization with fertility.
HORMONES AND BEHAVIOR
(2023)
Article
Chemistry, Physical
Wenli Zhao, Xiaopo Niu, Guangni Liu, Xiurong Zhang, Qingfa Wang
Summary: Three kinds of Pt nanocrystals with different morphologies were synthesized to prepare catalysts for the ring-opening reaction of decalin. The 5 nm truncated octahedral Pt/CNT-USY with exposed (100) and (111) facets showed higher yield of ring-opening products. Additionally, the 5 nm cubic Pt catalyst exhibited better catalytic activities compared to the 10 nm cubic Pt catalyst, attributed to the smaller size and more revealable metal active sites of Pt nanocrystals.
Article
Engineering, Multidisciplinary
Wenli Zhao, Kechen Song, Yanyan Wang, Shubo Liang, Yunhui Yan
Summary: This paper proposes a feature-aware network (FaNet) for few shot defect classification, which can effectively distinguish new classes with a small number of labeled samples. In FaNet, ResNet12 is used as the baseline, and the feature-attention convolution module (FAC) is applied to extract comprehensive feature information from the base classes. An online feature-enhance integration module (FEI) is adopted during the test phase to average the noise from defect images, further enhancing image features among different tasks. In addition, a large-scale strip steel surface defects few shot classification dataset (FSC-20) with 20 different types is constructed. Experimental results show that the proposed method achieves the best performance compared to state-of-the-art methods for 5-way 1-shot and 5-way 5-shot tasks. The dataset and code are available at: https://github.com/VDT-2048/FSC-20.
Article
Medicine, General & Internal
Lianghui Zhu, Huijuan Shi, Huiting Wei, Chengjiang Wang, Shanshan Shi, Fenfen Zhang, Renao Yan, Yiqing Liu, Tingting He, Liyuan Wang, Junru Cheng, Hufei Duan, Hong Du, Fengjiao Meng, Wenli Zhao, Xia Gu, Linlang Guo, Yingpeng Ni, Yonghong He, Tian Guan, Anjia Han
Summary: Using histology slides and a regional multiple-instance learning algorithm, the origin of bone metastatic cancer (OBMC) can be accurately predicted. The model demonstrated high accuracy and consistency in both internal and external validation. Assisting pathologists in determining the OBMC, the model holds significant importance in clinical therapeutics.
Review
Medicine, General & Internal
Yan Zhao, Wenli Zhao, Huaien Bu, Maeda Toshiyoshi, Ye Zhao
Summary: This study aimed to investigate the effects of liraglutide on type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Meta-analysis of 16 studies showed that liraglutide can reduce fasting plasma glucose levels, glycosylated hemoglobin A1c levels, triglyceride levels, total cholesterol levels, alanine aminotransferase levels and low-density lipoprotein cholesterol levels in patients, and there are no significant differences in aspartate transaminase and high-density lipoprotein cholesterol levels. However, there are some adverse effects. In conclusion, liraglutide is a potentially curative method for T2DM with NAFLD.
Article
Multidisciplinary Sciences
Xiu-Zhen Shi, Ming-Chong Yang, Xin-Le Kang, Yan-Xue Li, Pan-Pan Hong, Xiao-Fan Zhao, Gerardo R. Vasta, Jin-Xing Wang
Summary: The activation of the IMD pathway, critical for host immunity, is mediated by the receptor SRB2 in crustaceans. Depletion of SRB2 leads to increased bacterial proliferation, shrimp mortality, and decreased expression of antimicrobial peptides. This previously unrecognized SRB2-IMD axis provides insight into the innate immune response in crustaceans and has implications for prevention and treatment strategies against shrimp diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Fisheries
Yangguang Bao, Yuedong Shen, Zhaoxun Wu, Shunshun Tao, Bingqian Yang, Tingting Zhu, Wenli Zhao, Yingying Zhang, Xiaoyi Zhao, Lefei Jiao, Ziyi Wang, Qicun Zhou, Min Jin
Summary: In this study, an eight-week feeding trial was conducted to evaluate the regulatory effects of dietary Arachidonic acid (ARA) and its metabolites on inflammation, oxidative stress, and apoptosis in Acanthopagrus schlegelii. Results showed that high levels of dietary ARA induced inflammation by activating the gene expression levels of nuclear factor kappa B (nf-kappa b) and oxidative stress by reducing antioxidant parameters. Additionally, excess ARA levels promoted cell apoptosis by up-regulating pro-apoptotic gene expression levels.
AQUACULTURE REPORTS
(2023)
Article
Fisheries
Wenli Zhao, Jiaxiang Luo, Fang Fang, Tingting Zhu, Shichao Xie, Zheng Yang, Chen Guo, Yuhang Yang, Xiangkai Li, Lefei Jiao, Qicun Zhou, Min Jin
Summary: The study found that the diet with 10.75% lipid can improve the growth and feed utilization for juvenile Scylla paramamosain. Additionally, dietary lipid levels can affect antioxidant capacity, lipid metabolism, glucose metabolism, and insulin signaling pathway, with excessive lipid resulting in hepatopancreas lipid deposition.
AQUACULTURE REPORTS
(2023)
Article
Fisheries
Zheng Yang, Qicun Zhou, Chen Guo, Shichao Xie, Yingying Zhang, Tingting Zhu, Wenli Zhao, Jiaxiang Luo, Min Jin
Summary: Vegetable oil is being used as a substitute for fish oil in crustacean diets due to a global shortage. However, the effects of different substitution levels on the health and metabolism of crustaceans are not well understood. This study found that replacing 50% of fish oil with linseed oil did not affect the growth performance and feed utilization of juvenile swimming crab. Summary: A substitution ratio of less than 50% is recommended for linseed oil in the diet of Portunus trituberculatus.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Physical
Wenli Zhao, Zhen Cao, Zahra Bayhan, Hanfeng Liang, Yongjiu Lei, Long Chen, Mushtaq A. Dar, Zeyad Almutairi, Luigi Cavallo, Gang Huang, Husam N. Alshareef
Summary: This research presents a dendrite-free and highly stable Na metal anode by transferring a cation-deficient Ti0.87O2 nanosheet layer onto the Na surface. The Ti0.87O2 layer seamlessly connects to the Na surface and prevents layer fracture. It also has strong Na thorn adsorption ability, high ionic conductivity, and restricts Na plating, leading to improved performance of batteries.
MATERIALS TODAY ENERGY
(2023)
Article
Biotechnology & Applied Microbiology
Kun Wang, Mengqi Li, Bo Zhang, Yanpeng Chang, Shiheng An, Wenli Zhao
Summary: Sugar deficiency is a persistent challenge for plant development, and Trehalose-6-phosphate (T6P) is a key regulator in balancing plant sugar homeostasis. This study focuses on the sugar shortage in rice and reveals the underlying mechanisms by which sugar starvation limits plant development. The researchers identified a transcription factor OsSGI1 that is upregulated during sugar starvation and found that it directly binds to OsSnRK1a, leading to the inhibition of sugar metabolism and the promotion of trehalose 6-phosphate (Tre6P) accumulation. This study establishes the OsSGI1-OsTPP7-Tre6P loop, which is activated by sugar starvation and inhibits rice growth.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Xin Wen, Wenli Zhao, Zhenhao Yu, Jianxun Zhao, Kechen Song
Summary: This study proposes a novel anomaly detection method based on multi-scale knowledge distillation (Ms-KD) and a block domain core information module (BDCI) to quickly screen abnormal images in the surface inspection of strip steel. By utilizing the multi-scale knowledge distillation technique and the optimal storage of block-level features, the proposed method enables the student network to learn normal image information and better capture abnormal data to solve the imbalance problem. Experimental results showed the effectiveness of this method in strip steel defect anomaly detection, achieving high performance in image-level AUROC and pixel-level PRO indicators compared to state-of-the-art methods.
Article
Chemistry, Inorganic & Nuclear
Jie Song, Conggang Li, Jinmiao Jiao, Yuheng She, Wenli Zhao, Fei Liang, Ning Ye, Zhanggui Hu, Yicheng Wu
Summary: A prospective rare-earth borate UV NLO crystal, KNa2La2(BO3)(3), was extracted by spontaneous crystallization. This crystal exhibits strong second-harmonic generation (SHG) activity and a wide transparency window, making it a promising material for UV NLO applications.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Correction
Chemistry, Multidisciplinary
Lei Xue, Qing Shen, Tian Zhang, Yibin Fan, Xiaogang Xu, Jinjun Shao, Dongliang Yang, Wenli Zhao, Xiaochen Dong, Xiaozhou Mou
Summary: This study presents a strategy for enhanced photothermal and photodynamic antibacterial therapy through fluorescence resonance energy transfer post a single injection.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yuheng She, Fei Liang, Jinmiao Jiao, Wenli Zhao, Ning Ye, Zhanggui Hu, Yicheng Wu, Conggang Li
Summary: Polymorphism is essential for understanding crystallization mechanisms, predicting crystal structures, and discovering new materials. A new high-symmetry polymorph of Li2TeMo3O12, beta-Li2TeMo3O12, was identified using a spontaneous crystallization technique. It exhibits improved thermal stability and crystallizes in a different space group compared to the metastable form. The compound has a large bandgap and high transparency in a wide range of wavelengths, making it a promising material for mid-infrared applications. Additionally, it possesses interesting Raman characteristics, enabling it to function as a stimulated Raman laser.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Agriculture, Dairy & Animal Science
Jiaxiang Luo, Chen Ren, Tingting Zhu, Chen Guo, Shichao Xie, Yingying Zhang, Zheng Yang, Wenli Zhao, Xiangsheng Zhang, Jingjing Lu, Lefei Jiao, Qicun Zhou, Douglas R. Tocher, Min Jin
Summary: This study showed that a high-fat diet can improve the survival rate, weight gain, and feed efficiency of mud crabs in low salinity environments. The high-fat diet promotes lipolysis to provide more energy, thus enhancing energy metabolism and osmotic pressure regulation. Therefore, dietary lipid supplementation is important for low salinity adaptations in mud crabs.
