Article
Nanoscience & Nanotechnology
Jianhua Yan, Qifei Wang, Junlin Yang, Paige Rutter, Malcolm Xing, Bingyun Li
Summary: The use of antibiotics has led to the emergence of antibiotic-resistant bacteria. This study successfully reformulated silver and synthesized silver nanomaterials with improved antimicrobial properties and reduced toxicity. These nanomaterials showed high killing efficacy against Staphylococcus aureus and enhanced viability of human cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Infectious Diseases
Mohammad Asyraf Adhwa Masimen, Noor Aniza Harun, M. Maulidiani, Wan Iryani Wan Ismail
Summary: Antibiotics are a medical miracle, but bacteria quickly develop resistance, leading to MRSA becoming one of the most prominent antibiotic-resistant bacteria. Antimicrobial peptides and silver nanoparticles are considered alternative treatments for MRSA due to their broad-spectrum properties and potential synergistic effects.
Article
Multidisciplinary Sciences
Sadaf Raza, Asma Ansari, Nadir Naveed Siddiqui, Fariha Ibrahim, Muhammad Ishaque Abro, Afsheen Aman
Summary: This study utilized a biologically mediated approach to synthesize silver nanoparticles and silver-chitosan nanocomposites, characterizing them through various spectroscopic analyses and demonstrating their promising antimicrobial potential. The silver-chitosan nanocomposites exhibited synergistic behavior against various bacterial species and showed no cytotoxic effects on NIH/3T3 cell lines.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Physical
Navid Rabiee, Sepideh Ahmadi, Omid Akhavan, Rafael Luque
Summary: This article discusses the synthesis and modification methods of silver and gold nanoparticles, as well as their physicochemical properties. It reviews the latest studies to find the best relationship between the nanoparticles' physicochemical properties and antimicrobial activity, and discusses the possible antimicrobial mechanisms of these nanoparticles.
Article
Pharmacology & Pharmacy
Samir Haj Bloukh, Zehra Edis, Hamid Abu Sara, Mustafa Ameen Alhamaidah
Summary: Plant-based compounds are valuable in combating multidrug-resistant microorganisms, offering alternatives to common drugs. Combining garden cress and silver nanoparticles can prevent microbial resistance through plant-based synergistic mechanisms within nanomaterials. The bio-nanohybrid LS-AgNP has potential uses as a broad-spectrum microbicide, disinfectant, and wound care product.
Article
Chemistry, Multidisciplinary
Agata Zamborlin, Maria Laura Ermini, Maria Summa, Giulia Giannone, Valentina Frusca, Ana Katrina Mapanao, Doriana Debellis, Rosalia Bertorelli, Valerio Voliani
Summary: The intranasal administration of drugs provides an effective and noninvasive treatment for respiratory tract diseases. However, limited data on the biosafety and nano/biointeractions of metal nanoparticles restrict their use. This study quantitatively and qualitatively assesses the fate and potential risks of a silver nanomaterial model after a single dose instillation, highlighting the importance of nanomaterial design and metal chemistry in biodistribution and nano/biointeractions. Rational engineered nanomaterials may be exploited for future treatments of (non)communicable respiratory diseases.
Article
Engineering, Biomedical
Victor M. Villapun, Dario L. Balacco, Mark A. Webber, Thomas Hall, Morgan Lowther, Owen Addison, Sarah A. Kuehne, Liam M. Grover, Sophie C. Cox
Summary: Antimicrobial resistance is a major threat to modern medicine, with research showing that bacteria exposed to silver gradually become more susceptible over time, while ciprofloxacin leads to the selection of resistance with prolonged exposure.
ACTA BIOMATERIALIA
(2021)
Article
Infectious Diseases
Rula M. Darwish, Ali H. Salama
Summary: This study evaluated the antibacterial activity of Tryasine peptide conjugated with silver nanoparticles against selected pathogens. The results showed that the conjugate had good antibacterial activity against Gram-positive and Gram-negative bacteria, with low toxicity.
Article
Environmental Sciences
Sohaib Ashraf, Shoaib Ashraf, Moneeb Ashraf, Muhammad Ahmad Imran, Zawar Ahmad Choudhary, Hadiqa Tul Hafsa, Abeer Bin Awais, Larab Kalsoom, Iqra Farooq, Zaighum Habib, Sidra Ashraf, Qurrat Ul Ain Iqbal, Muhammad Ghufran, Syed Sami Hussain Sherazi, Muhammad Kiwan Akram, Rutaba Akmal, Sundas Rafique, Khawar Nawaz, Zartasha Safdar, Uzma Nasim Siddique, Muhammad Hassan, Shahroze Arshad, Abdul Rehman Virk, Muhammad Ashraf, Qazi Abdul Saboor, Ayesha Humayun, Mateen Izhar
Summary: The study shows that doctors have a good awareness of antimicrobial resistance as a global issue, but there is still a lack of knowledge regarding rational antibiotic use. Most doctors expressed a desire to improve their understanding of antimicrobial drugs and their appropriate usage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Laurent A. Bekale, Devesh Sharma, Brian Bacacao, Jing Chen, Peter L. Santa Maria
Summary: Bacteria develop tolerance after antibiotic exposure, followed by genetic resistance through the population of tolerant bacteria. Bacterial persister cells, a subpopulation within bacteria culture, maintain genetic susceptibility to antibiotics. The low metabolic activity of persister cells can be exploited for eradication, and gold nanoclusters coated with adenosine triphosphate (AuNC@ATP) can kill persister cells. Using AuNC@ATP, it is possible to prevent the emergence of antibiotic-resistant superbugs by eradicating persister cells in bacteria culture.
Article
Chemistry, Multidisciplinary
Maryam Shahid, Riaz Hussain, Zeeshan Nawaz, Bilal Aslam, Muhammad Zishan Ahmad, Abu Baker Siddique, Hira Ahsan, Aiman Fatima, Iahtasham Khan, Bilal Mustafa, Rashid Iqbal, Khalid M. Al Syaad, Ashwag Shami
Summary: The occurrence of Staphylococcus aureus-induced subclinical mastitis has significant implications for public health. This study found a high prevalence of this bacterium in dairy cows, as well as antimicrobial resistance and multiple virulence genes.
Article
Immunology
Winston E. Anthony, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon
Summary: This review discusses the gut as a reservoir for antimicrobial resistance and pathogen colonization, with a focus on beta-lactam and plasmid-mediated quinolone resistance. It also explores the use of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome, as well as the potential for future microbiome-directed methods for detecting and preventing infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Jennifer Guiraud, Manon Lounnas, Anne Boissiere, Chloe Le Roy, Eric Elguero, Anne Laure Banuls, Cecile Bebear, Sylvain Godreuil, Sabine Pereyre
Summary: The study found that Mycoplasma genitalium strains in men who have sex with men are more likely to be resistant to macrolides, with a higher prevalence of macrolide resistance among this group. Different genetic profiles were identified within M. genitalium, with a lower diversity of mgpB types observed in macrolide-resistant strains, potentially due to the easier spread of specific mgpB types or the existence of sexual networks among men who have sex with men.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Alicia Rodriguez-Gascon, Maria angeles Solinis, Arantxa Isla
Summary: PK/PD analysis is essential in establishing rational dosage regimens of antimicrobial agents in human and veterinary medicine. It involves the use of different models and mathematical models to determine optimal dosing regimens and prevent the emergence of resistance. PK/PD analysis plays a crucial role in the development of new antibiotics and optimization of current drug dosage regimens.
Article
Immunology
Brigid M. Wilson, Yunyun Jiang, Robin L. P. Jump, Roberto A. Viau, Federico Perez, Robert A. Bonomo, Scott R. Evans
Summary: Antibiotic stewardship must consider effectiveness and spectrum of therapy, proposing the DOOR MAT approach for evaluating desirability of antibiotic selection. The principle is to effectively treat the patient while minimizing future resistance development.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Xun Wang, Cody G. Cole, Cory D. DuPai, Bryan W. Davies
Article
Chemistry, Inorganic & Nuclear
Orhi Esarte Palomero, Richard A. Jones
Article
Biochemistry & Molecular Biology
Cory D. DuPai, Bryan W. Davies, Claus O. Wilke
Summary: The beta hairpin motif is a widely distributed protein structural motif known for its stability and adaptability to various functions. Research revealed that specific amino acid preferences within the structure, particularly in the turn region, depend on subtle dynamics associated with turn length and secondary structure. Broad design principles, such as including specific aspartic acid residues and considering desired secondary structure in selecting residues for the turn region, were established for generating libraries encoding proteins or peptides containing beta hairpin structures.
Article
Chemistry, Inorganic & Nuclear
Tyler L. King, Orhi Esarte Palomero, Alexander B. Bard, Joe A. Espinoza, Hongyu Guo, Desmond Schipper, Xiaoping Yang, Lauren J. DePue, Emily L. Que, Richard A. Jones
Summary: Three thermodynamically stable nano-sized complexes containing 42 Ln(3+) ions in a single molecule were synthesized via a self-assembly process. The compounds have torus or wheel-like architectures and are the first reported visibly luminescent lanthanide nanotoroids for Eu and Tb. Single crystal structures of all three complexes and their photophysical properties have been reported.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Microbiology
Heidi A. Butz, Alexandra R. Mey, Ashley L. Ciosek, Alexander A. Crofts, Bryan W. Davies, Shelley M. Payne
Summary: CsrA is a critical posttranscriptional global regulator in Vibrio cholerae, controlling 22% of the bacterial transcriptome involving various cellular processes. Through RNA coimmunoprecipitation experiments, it was found that CsrA binds to multiple mRNAs encoding regulatory proteins, including major sigma factors. Additionally, CsrA directly binds to virulence gene transcripts, positively regulating the production of important virulence factors.
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Microbiology
Justin R. Randall, Bryan W. Davies
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Justin R. Randall, Gillian Davidson, Renee M. Fleeman, Santos A. Acosta, Ian M. Riddington, T. Jeffrey Cole, Cory D. DuPai, Bryan W. Davies
Summary: The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. In this study, a synthetic peptide antibiotic called Symbah-1 was identified, which functions through membrane disruption and exhibits broad spectrum bactericidal activity against drug-resistant pathogens. The study also characterized the structure of Symbah-1 and identified variants with increased serum activity and protease resistance.
Review
Physiology
Orhi Esarte Palomero, Megan Larmore, Paul G. DeCaen
Summary: Polycystin subunits form hetero- and homotetrameric ion channels in cell membranes, with heterotetrameric versions being regulated by ligands or autoproteolysis and homotetrameric versions being voltage- and calcium-modulated. These channels play vital roles in autosomal dominant polycystic kidney disease, fertilization, and embryonic development. The diversity in polycystin assembly and subcellular distribution allows for a variety of sensory functions, and recent studies have provided insights into their structure and function, shedding light on the conformational changes needed for channel opening in response to unique stimuli.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Orhi Esarte Palomero, Richard A. Jones
Summary: The reaction of 1,1 '-diazidoferrocene, PMe3 and 2,6-di(phenylmethyl)-4-methylphenylisocyanate (1) leads to the synthesis of a novel hyperbulky proligand 1,1 '-(2,6-di(phenylmethyl)-4-methylphenyl)carbodiimidoferrocene (2), along with other compounds (3) and (4). Compound 2 exists in equilibrium with its 2,4-diimino-1,3-diazetidine form (3) in solution. Reaction of 2 with Zr(NMe2)4 results in the formation of a zirconium pincer bis(guanidinate) complex (5) with unique binding motifs for the guanidinate groups due to the bulky ligand scaffold. The electrochemical properties of compounds 2, 3 and 5 in solution were studied using cyclic voltammetry.
Article
Chemistry, Inorganic & Nuclear
Orhi Esarte Palomero, Richard A. Jones
Summary: The synthesis of novel ferrocene tethered boramidinate frustrated Lewis pairs (FLPs) capable of sequentially capturing small molecules is reported. The reactivity of the boramidinate moieties can be tuned by altering the substituents and borane used in the reduction. Independent small molecule capture by each FLP has been demonstrated, allowing for sequential capture of different gaseous small molecules.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Tyler L. King, Orhi Esarte Palomero, Dawson A. Grimes, Sean T. Goralski, Richard A. Jones, Emily L. Que
Summary: This study investigates the extraction of metal ions using a fluorinated acetylacetonate pro-ligand into a perfluorocarbon phase, with a focus on characterizing the speciation of the extracted metal complexes. The findings suggest that the formation of coordinatively saturated mononuclear metal complexes in the fluorous phase is crucial for retaining the extracted species, and synergistic extraction plays an important role for metal ions that do not form these types of metal complexes with acetylacetonate ligands alone.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)
