Journal
INFLAMMATORY BOWEL DISEASES
Volume 27, Issue 8, Pages 1335-1345Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izab012
Keywords
inflammatory bowel diseases; Crohn disease; ulcerative colitis; metabolomics; gas chromatography-mass spectrometry
Categories
Funding
- [LR7/2007]
- [CRP 18488]
Ask authors/readers for more resources
This study found differences in metabolomics profiles between patients with CD and UC compared to the control group, with changes in energetic metabolism, lactic acid, and ornithine appearing in both plasma and colon biopsies. Additionally, metabolic changes were observed between normal ileum and colon tissues, highlighting potential applications in precision medicine and better understanding the pathogenesis of IBD.
Background: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, with periods of latency alternating with phases of exacerbation, and include 2 forms: Crohn disease (CD) and ulcerative colitis (UC). Although the etiology of IBD is still unclear, the identification and understanding of pathophysiological mechanisms underlying IBD could reveal newly targeted intestinal alterations and determine therapeutic approaches. Methods: In this study, by using gas chromatography-mass spectrometry, we characterized plasma and biopsies from the metabolomics profiles of patients with IBD compared with those of a control group. Results: The results showed a different metabolomics profile between patients with CD (n=50) and patients with UC (n=82) compared with the control group (n=51). Multivariate statistical analysis of the identified metabolites in CD and UC showed changes in energetic metabolism, and lactic acid and ornithine in particular were altered in both plasma and colon biopsies. Moreover, metabolic changes were evidenced between the normal ileum and colon tissues. These differences disappeared when we compared the inflamed ileum and colon tissues, suggesting a common metabolism. Conclusions: This study showed how the metabolomics profile could be a potential tool to identify intestinal alterations associated with IBD and may have application in precision medicine and for better defining the pathogenesis of the disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available