Journal
HAEMATOLOGICA
Volume 106, Issue 5, Pages 1443-1456Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2020.264523
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Funding
- American University of Beirut Medical Practice Plan
- University Research Board
- Lebanese National Council for Scientific Research
- Lady TATA Memorial Trust
- European Research Council [268729]
- Ligue Nationale Contre le Cancer, Centre National de la Recherche Scientifique
- Association de Recherche Contre le Cancer
- Institut National Contre le Cancer
- Cancerople Ile de France
- European Research Council (ERC) [268729] Funding Source: European Research Council (ERC)
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Combining arsenic trioxide and interferon-alpha shows high response rate in chronic ATL patients by shutting down IL-10 expression to eliminate leukemia-initiating cell activity, leading to immune-mediated clearance of leukemic cells.
Adult T-cell leukemia/lymphoma (ATL) is associated with chronic human T-cell leukemia virus type 1 infection and carries a poor pro gnosis. Arsenic trioxide (AS) and inter feron-alpha (IFN alpha) together selectively trigger Tax viral oncoprotein degradation and cure Tax-driven murine ATL. AS/IFN alpha/zidovudine treatment achieves a high response rate in patients with chronic ATL. Interleukin 10 (IL-10) is an immuno-suppressive cytokine whose expression is activated by Tax. Here we show that, in ATL, AS/IFN alpha-induced abrogation of leukemia-initiating cell activity requires IL-10 expression shutoff. Loss of IL-10 secretion drives production of inflammatory cytokines by the microenvironment, followed by innate immunity-mediated clearance of Tax-driven leukemic cells. Accordingly, anti-IL-10 monoclonal antibodies significantly increased the efficiency of AS/IFN alpha therapy. These results emphasize the sequential targeting of malignant ATL cells and their immune microenvironment in leukemia-initiating cell eradication and provide a strong rationale to test the AS/IFN alpha/anti-IL10 combination in ATL.
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