Plasma Modification of PLA/PGA Embedding Threads with Different Proportions: A Strategy for Developing Novel ACET Materials

Polylactic acid (PLA) and polyglycolic acid (PGA) have been widely used in the acupoint catgut embedding therapy (ACET) field. However, some defects such as hydrophobicity, poor swelling and cell adhesion properties which significantly limit their further applications. Herein, we report a strategy for developing ACET materials via 3D fabrication and plasma treatment. The results showed that modified samples showed rougher surface morphology and better hydrophilicity. Sample L4G0 (PLA strands: PGA strands=4:0) showed the largest tensile strength and elongation values at 32.15 +/- 5.26 cN/dtex and 56.37 +/- 4.38 %, respectively. Samples were proved to be non-toxicity and had better cell attachment and tissue growth ability after modification. In sum, the strategy of plasma modified PLA/PGA is deserved to be further studied with outstanding clinical efficacy.

Automated summary

A strategy for developing ACET materials via 3D fabrication and plasma treatment was reported, with modified samples showing rougher surface morphology and better hydrophilicity. Sample L4G0 exhibited the largest tensile strength and elongation values, showcasing non-toxicity and improved cell attachment and tissue growth ability after modification.