Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jinrui Yang, Xiaoqiang Liu, Wenping Wang, Ying Chen, Jie Liu, Ze Zhang, Chao Wu, Xupin Jiang, Yi Liang, JiaPing Zhang
Summary: This study investigated the coordination function of electric fields (EFs) on wound healing and found that EF promotes wound contraction and re-epithelialization, accelerating the healing process. In vitro experiments demonstrated that EFs promote cell migration and collagen secretion. These findings support the continued development of EF for wound treatment applications.
BIOELECTROCHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Catalina Ruiz-Canada, Angel Bernabe-Garcia, Sergio Liarte, Monica Rodriguez-Valiente, Francisco Jose Nicolas
Summary: The application of amniotic membrane on chronic wounds has shown effectiveness in resetting wound healing, particularly in re-epithelialization. Amniotic membrane affects wound healing by modulating cell signaling pathways and growth factors. Additionally, it influences protein expression in epithelial cells, promoting the progression of re-epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chi Yuan, Jian Liao, Liying Zheng, Lingzhi Ding, Xiao Teng, Xuesong Lin, Le Wang
Summary: This review examines the association between leptin and wound healing, speculating on the molecular mechanisms and the need for further research to understand its specific role in different phases of wound repair.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Emergency Medicine
Zengjun Yang, Xiaohong Hu, Lina Zhou, Yaxiong He, Xiaorong Zhang, Jiacai Yang, Zhenyu Ju, Yih-Cherng Liou, Han-Ming Shen, Gaoxing Luo, Michael R. Hamblin, Weifeng He, Rui Yin
Summary: PDT accelerates wound healing by enhancing EpSC differentiation, proliferation, and migration, promoting re-epithelialization and angiogenesis while modulating skin homeostasis. This method also inhibits inflammatory responses and increases the secretion of growth factors.
Article
Engineering, Biomedical
Chenbing Wang, Chenyu Chu, Xiwen Zhao, Yang Yang, Chen Hu, Li Liu, Jidong Li, Yili Qu, Yi Man
Summary: Topographical properties of biomaterials have important effects on cell activities and immune response during wound healing. The study found that an electrospinning membrane with a fiber diameter of 319 nm (A300) showed enhanced cell proliferation, wound healing, and keratinocyte migration, making it a potential candidate for skin regeneration applications.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Lucas F. S. Gushiken, Fernando P. Beserra, Maria F. Hussni, Murilo T. Gonzaga, Victor P. Ribeiro, Patricia F. de Souza, Jacqueline C. L. Campos, Tais N. C. Massaro, Carlos A. Hussni, Regina K. Takahira, Priscyla D. Marcato, Jairo K. Bastos, Claudia H. Pellizzon
Summary: This study investigated the potential of using Copaifera langsdorffii oleoresin combined with nanostructured lipid carriers for wound healing. The results demonstrated that this treatment promoted wound retraction and tissue remodeling, with anti-inflammatory and antioxidant effects, suggesting it as a potential alternative treatment for skin wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
F. De Francesco, A. Saparov, M. Riccio
Summary: This study assessed the effectiveness of hyaluronic acid-based cream and gauze pads in cutaneous wounds and found that treatment with 0.2% hyaluronic acid cream or gauze pads can promote wound healing and recovery with good tolerance among patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xanthe L. L. Strudwick, Jason D. D. Whittle, Allison J. J. Cowin, Louise E. E. Smith
Summary: Fundamental knowledge about cell-surface interactions can be used in the development of wound dressings and scaffolds that promote wound healing. Plasma-coating wound dressings with acid-functionalised monomers or amine functionalisation can enhance cell adhesion, proliferation, and migration. In an in vivo study on mice, dressings coated with allylamine showed increased wound healing rate and reduced wound area, while prolonged treatment with allylamine-functionalised dressings may impair healing. Acrylic acid functionalisation did not improve early wound healing, but promoted collagen deposition at a later stage. This suggests that plasma polymerisation can lead to the development of new dressings that enhance wound closure by directing cell behavior, but a timed approach may be necessary for their application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Zhihong Zheng, Na Sun, Zhiqiang Lu, Jingru Zheng, Simin Zhang, Songyi Lin
Summary: Sea cucumber derived tetrapeptides VTPY and VLLY have the potential to promote wound healing by promoting reepithelialization, collagen and lipid regeneration, and enhancing angiogenesis. VTPY works better than VLLY, indicating their potential as natural food source-derived candidates for promoting skin wound healing.
Article
Pharmacology & Pharmacy
Juin-Hong Cherng, Sheng-Chieh Chou, Chin-Li Chen, Yi-Wen Wang, Shu-Jen Chang, Gang-Yi Fan, Fang-Shiuan Leung, En Meng
Summary: The study demonstrates that bacterial cellulose (BC) scaffold has a significant promoting effect on epithelial regeneration and wound healing, improving the wound microenvironment and aiding in the maintenance and restoration of injured epidermis. Compared to collagen material, BC scaffold can enhance beneficial tissue repair by regulating the functional balance of macrophages.
Article
Engineering, Biomedical
Sang Oon Baek, Uk Jang, Jeonghwan Shin, Jun Hyeok Kim, Jie Hyun Kim, Jun Yong Lee
Summary: The authors introduce a novel animal wound model using an internal splint made of nitinol, a shape memory alloy, to effectively impede wound contraction while not affecting the re-epithelialization rate, successfully mimicking the human wound healing mechanism. This model is robust, reliable, and easily reproducible.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wei Xu, Elodi Dielubanza, Amanda Maisel, Kai Leung, Thomas Mustoe, Seok Hong, Robert Galiano
Summary: Chronic wounds are often caused by bacterial contamination, with Staphylococcus aureus being a common strain. Inhibition of keratinocyte migration by S. aureus exudate may involve the upregulation of connexin-43 (Cx43). The treatment of bacterium-infected wounds may be improved by targeting Cx43 and Akt to overcome wound closure impairment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Emergency Medicine
Yunxia Chen, Xiaorong Zhang, Zhihui Liu, Jiacai Yang, Cheng Chen, Jue Wang, Zengjun Yang, Lei He, Pengcheng Xu, Xiaohong Hu, Gaoxing Luo, Weifeng He
Summary: The study showed that wound-healing rate, re-epithelialization, formation of granulation tissue, and inflammatory infiltration were greater in the Cut group compared to the SDDS and TDS groups. The number of blood vessels reached a peak in the Cut group, and the healing quality of the SDDS group was better compared to the Cut and TDS groups.
Review
Biochemistry & Molecular Biology
Nurmaziah Mohammad Shafie, Raja Nazatul Izni Raja Shahriman Shah, Puspawathy Krishnan, Noorashikin Abdul Haleem, Terence Yew Chin Tan
Summary: Through a systematic review, it was found that Moringa oleifera has the potential to promote wound healing. The accumulation of collagen content and bioactive phytochemicals with antimicrobial, antioxidant, and anti-inflammatory activities in M. oleifera can accelerate wound contraction, increase epithelialization rate, and protect tissues against oxidative damage. However, further studies are needed to determine the main bioactive phytocompounds and safety.
Review
Pharmacology & Pharmacy
David Dolivo, Pamela Weathers, Tanja Dominko
Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell & Tissue Engineering
David Dolivo, Ping Xie, Chun Hou, Yingxing Li, Abigail Phipps, Thomas Mustoe, Seok Hong, Robert Galiano
Summary: This study investigated the effects of HR-ADM application on wound closure using a diabetic murine model. The results showed that HR-ADM promoted rapid wound closure and minimized granulation tissue formation. HR-ADM also facilitated cellular infiltration, neovascularization, and collagen remodeling in the wounds.
Review
Genetics & Heredity
David M. Dolivo
Summary: Fibrosis is a pathological tissue repair process that leads to nearly half of deaths in developed countries. Current therapies targeting fibrosis are lacking, highlighting the significance of basic science research and anti-fibrotic modalities.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Dermatology
Adrian E. Rodrigues, David Dolivo, Yingxing Li, Thomas A. Mustoe, Robert Galiano, Seok Jong Hong
Summary: Understanding burn wound models is crucial for developing effective treatments for burn scars, as deep dermal wounds and thermal injuries often result in hypertrophic scar formation. Preclinical burn wound models that accurately simulate human burn-induced wound healing processes are essential for advancing research in this area.
ADVANCES IN WOUND CARE
(2022)
Article
Cell Biology
David Dolivo, Steven Lanier, Kai Leung, Thomas Mustoe, Seok Jong Hong, Robert Galiano
Summary: Infection is a major complication in delayed diabetic wound healing. Comparative analysis of bacterial gene expression profiles in non-diabetic and diabetic mice with infected wounds revealed significant transcriptomic differences between the two groups at day 3, which were mostly resolved by day 7. The differentially expressed genes at day 7 were mainly related to carbohydrate metabolism and capsular polysaccharide synthesis. Further research on host-pathogen interactions in wound healing and their influence on diabetic wound outcomes is encouraged.
WOUND REPAIR AND REGENERATION
(2022)
Article
Dermatology
David Dolivo, Adrian Rodrigues, Lauren Sun, Chun Hou, Yingxing Li, Eugene Chung, Kai Leung, Robert Galiano, Thomas Mustoe, Seok Jong Hong
Summary: The study found that topical application of 10% simvastatin cream can reduce scar hypertrophy, but creams containing the other two drugs are ineffective. It also found that the use of simvastatin cream can result in dryness and trans-epidermal water loss, but discontinuation of the treatment can restore the skin's protective barrier.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Dolivo, Adrian Rodrigues, Lauren Sun, Robert Galiano, Thomas Mustoe, Seok Jong Hong
Summary: Damage to the epidermis results in exacerbated inflammatory signaling, leading to further impairment of the skin barrier. The CD14/S100 signaling pathway has been identified as upregulated in dermatopathologies associated with compromised epidermal barrier. In vitro experiments have shown that CD14 can modulate the expression of inflammatory genes, such as the S100 family genes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Pathology
David M. Dolivo, Lauren S. Sun, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrotic skin conditions, such as hypertrophic and keloid scars, can cause patient discomfort and cosmetic disfigurement. Current treatments for skin fibrosis are limited, and there is a lack of understanding about the role of aberrations in fibrotic epidermis in dermal fibrosis. This review examines occlusion as a potential treatment for dermal fibrosis and emphasizes the importance of epidermal-dermal crosstalk in the development and maintenance of fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
David Dolivo, Ping Xie, Lauren Sun, Chun Hou, Abigail Phipps, Thomas A. Mustoe, Seok Jong Hong, Robert D. Galiano
Summary: Chronic or delayed healing wounds are a significant burden for healthcare providers and patients. Using human amnion-derived grafts (viable or devitalized) can promote wound healing by enhancing key processes such as granulation tissue formation and re-epithelialization.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Dermatology
David M. Dolivo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: The discovery of novel antifibrotic therapies is of great importance due to the high prevalence of fibrotic diseases and the lack of effective pharmacologic modalities. Repurposing drugs with existing mechanisms of action and/or clinical data is a promising approach for treating fibrotic diseases. This study used a gene expression paradigm characteristic of activated myofibroblasts in combination with the Connectivity Map to select compounds that have the potential to reverse the pathological gene expression signature associated with myofibroblasts and act as antifibrotic compounds. Testing on fibroblasts identified the retinoic acid receptor agonist Ch55 as a potential hit, and further investigation demonstrated its antifibrotic effects and antiscarring activity in vitro and in a preclinical rabbit ear hypertrophic scar model. The discovery of antiscarring compounds through similar predictions may lead to further preclinical and ultimately clinical success.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Chemistry, Multidisciplinary
David M. Dolivo, Adrian E. Rodrigues, Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong
Summary: Cellular therapies hold promise for fibrosis treatment. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. The discussion highlights the strengths of this approach and its potential to generalize to treat other forms of fibrosis.
Review
Pharmacology & Pharmacy
David M. Dolivo, Charlotte R. Reed, Kristine A. Gargiulo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrosis is a common pathological repair process in organs, but there is a lack of effective therapeutic methods. Repurposing existing drugs, such as statins, can be a complementary strategy to treat tissue fibrosis. Statins have been found to have anti-fibrotic effects through various mechanisms, and a better understanding of these effects can aid in the development of novel therapeutic agents.
BIOCHEMICAL PHARMACOLOGY
(2023)
Meeting Abstract
Cell Biology
Adrian Rodrigues, David Dolivo, Yingxing Li, Lauren Sun, Chun Hou, Thomas Mustoe, Seok Jong Hong, Robert Galiano
WOUND REPAIR AND REGENERATION
(2022)
Meeting Abstract
Cell Biology
David Dolivo, Steven Lanier, Kai P. Leung, Thomas Mustoe, Seok Jong Hong, Robert Galiano
WOUND REPAIR AND REGENERATION
(2022)
Meeting Abstract
Cell Biology
David Dolivo, Ping Xie, Lauren Sun, Chun Hou, Abigail Phipps, Thomas Mustoe, Seok Jong Hong, Robert Galiano
WOUND REPAIR AND REGENERATION
(2022)