Diverse chemical space of indoleamine-2,3-dioxygenase 1 (Ido1) inhibitors

Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase

(2020) Shixian Hua et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors

(2020) Xiaohan Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

(2020) Yi-Hui Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3

(2020) Rizhen Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA Encoded Library Technology-based discovery, lead optimization and prodrug strategy toward structurally-unique indoleamine 2,3-dioxygenase (IDO1) inhibitors.

(2020) Wieslaw M. Kazmierski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity

(2020) Marta Serafini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors

(2020) Chuan Zhou et al.   MOLECULES

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)

(2020) Catherine White et al.   ACS Medicinal Chemistry Letters

Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1

(2020) Shanshan Jiang et al.   Aging-US

Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase

(2020) Yuanyuan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

(2019) Hongchuan Zhao et al.   MOLECULES

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors

(2019) Yuyang Ding et al.   BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors

(2019) Xiaojun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors

(2019) Marta Serafini et al.   MOLECULES

Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1

(2019) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of novel imidazoles as IDO1 inhibitors through microwave‐assisted one‐pot multicomponent reactions

(2019) Zhizheng Bai et al.   ARCHIV DER PHARMAZIE

Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO

(2019) Xi Feng et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and biological evaluation of bicyclic carboxylic acid derivatives as IDO1 inhibitors

(2019) Shi Cai et al.   BIOORGANIC CHEMISTRY

Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors

(2019) Shulun Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase

(2019) Dan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization and Nonenzymatic Transformation of Three Types of Alkaloids from Streptomyces albogriseolus MGR072 and Discovery of Inhibitors of Indoleamine 2,3-Dioxygenase

(2019) Du Gao et al.   ORGANIC LETTERS

Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

(2019) Kai-min Kong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors

(2019) Guonan Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth

(2019) Subhankar Panda et al.   Scientific Reports

Evaluation of the andrographolides role and its indoleamine 2,3-dioxygenase inhibitory potential and attendant molecular mechanism against STZ-induced diabetic rats

(2019) Munipally Praveen Kumar et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies

(2018) Alessia Griglio et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of a series of novel o -phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

(2018) David K. Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

(2018) Shu-Yu Lin et al.   BIOORGANIC CHEMISTRY

IDO1 in cancer: a Gemini of immune checkpoints

(2018) Lijie Zhai et al.   Cellular & Molecular Immunology

Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1

(2018) Yan–Xiang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy

(2018) Tianwei Weng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ethylnaphthoquinone derivatives as inhibitors of indoleamine-2, 3-dioxygenase from the mangrove endophytic fungus Neofusicoccum austral SYSU-SKS024

(2018) Hui Cui et al.   FITOTERAPIA

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

(2018) Kun Fang et al.   ACS Medicinal Chemistry Letters

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold

(2018) Michael G. Brant et al.   ACS Medicinal Chemistry Letters

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

(2018) Lilla Hornyák et al.   Frontiers in Immunology

Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors

(2018) Rui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors

(2018) Liangkun Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO)

(2018) Jyoti Chauhan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches

(2017) Yi Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fragment-based approach to identify IDO1 inhibitor building blocks

(2017) Alice Coletti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

(2017) Stefano Crosignani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Molecular Modeling Studies of N′-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

(2017) Dong-Ho Lee et al.   MOLECULES

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

(2017) Alice Coletti et al.   MedChemComm

Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1

(2017) Saurav Paul et al.   MedChemComm

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

(2017) Eddy W. Yue et al.   ACS Medicinal Chemistry Letters

Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B

(2016) Zenyu Shiokawa et al.   ChemMedChem

Nitrobenzofurazan derivatives of N ′ - hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1

(2016) Saurav Paul et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation

(2016) Antonio Coluccia et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors

(2016) S. Fallarini et al.   MedChemComm

Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors

(2016) Subhankar Panda et al.   ACS Medicinal Chemistry Letters

Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity

(2015) Christopher E. Blunt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase

(2015) Esther Jortzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection

(2015) Quentin Lepiller et al.   Journal of Innate Immunity

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

(2015) Shu-Yu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

(2015) Amy B. Dounay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

(2015) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

(2015) Yi-Hui Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium

(2015) Joyce A. Ibana et al.   Reproductive Sciences

Discovery and structure–activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors

(2014) Ming-Fu Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

(2014) Ute F. Röhrig et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

(2014) Silvia Serra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation

(2014) Catarina Carvalho et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Indoleamine 2,3-Dioxygenase Inhibitors Isolated from the Sponge Xestospongia vansoesti: Structure Elucidation, Analogue Synthesis, and Biological Activity

(2014) Ryan M. Centko et al.   ORGANIC LETTERS

Effects of Various Phytochemicals on Indoleamine 2,3-Dioxygenase 1 Activity: Galanal Is a Novel, Competitive Inhibitor of the Enzyme

(2014) Rie Yamamoto et al.   PLoS One

Indoleamine 2,3-Dioxygenase Inhibitors: Potential Treatment for Cancer, Sepsis, and More

(2014) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

(2014) Shingo Tojo et al.   ACS Medicinal Chemistry Letters

New Insights into IDO Biology in Bacterial and Viral Infections

(2014) Susanne V. Schmidt et al.   Frontiers in Immunology

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)

(2013) Sai-Parng S. Fung et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aminophenoxazinones as Inhibitors of Indoleamine 2,3-Dioxygenase (IDO). Synthesis of Exfoliazone and Chandrananimycin A

(2013) Raffaele Pasceri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2,3-Dioxygenase with Therapeutic Activity in Lewis Lung Cancer (LLC) Tumor-Bearing Mice

(2013) Shuangshuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Product-Inspired Pyranonaphthoquinone Inhibitors of Indoleamine 2,3-Dioxygenase-1 (IDO-1)

(2012) David J. A. Bridewell et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A

(2012) Eduard Dolušić et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection

(2012) Trevor W. Stone et al.   FEBS Journal

Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315

(2012) Jun-Pil Jang et al.   JOURNAL OF ANTIBIOTICS

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

(2012) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

(2011) David Meininger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives

(2011) J. Reniers et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors

(2011) Qiang Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

(2010) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

(2010) David J. Bonda et al.   REDOX REPORT

The Selenazal Drug Ebselen Potently Inhibits Indoleamine 2,3-Dioxygenase by Targeting Enzyme Cysteine Residues

(2009) Andrew C. Terentis et al.   BIOCHEMISTRY

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

(2009) Eddy W. Yue et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the FungusPlectosphaerella cucumerina

(2009) Gavin Carr et al.   ORGANIC LETTERS

Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors

(2008) Hitomi Nakashima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

(2008) Radim Vrzal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

(2008) Gavin Carr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY