Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target

Toxicity, transfer and depuration of anatoxin-a (cyanobacterial neurotoxin) in medaka fish exposed by single-dose gavage

(2020) Simon Colas et al.   AQUATIC TOXICOLOGY

Combined toxic effects of anatoxin-a and microcystin-LR on submerged macrophytes and biofilms

(2020) Qi Li et al.   JOURNAL OF HAZARDOUS MATERIALS

First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France

(2020) Ronel Biré et al.   Marine Drugs

Neurotoxic Anatoxin-a Can Also Exert Immunotoxicity by the Induction of Apoptosis on Carassius auratus Lymphocytes in vitro When Exposed to Environmentally Relevant Concentrations

(2020) Yuchi Zhong et al.   Frontiers in Physiology

Toxic benthic freshwater cyanobacterial proliferations: Challenges and solutions for enhancing knowledge and improving monitoring and mitigation

(2020) Susanna A. Wood et al.   FRESHWATER BIOLOGY

Impacts of microbial assemblage and environmental conditions on the distribution of anatoxin-a producing cyanobacteria within a river network

(2019) Keith Bouma-Gregson et al.   ISME Journal

Evolution of vertebrate nicotinic acetylcholine receptors

(2019) Julia E. Pedersen et al.   BMC EVOLUTIONARY BIOLOGY

Unmasking the identity of toxigenic cyanobacteria driving a multi-toxin bloom by high-throughput sequencing of cyanotoxins genes and 16S rRNA metabarcoding

(2019) María Cristina Casero et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings

(2019) Zorica Svirčev et al.   ARCHIVES OF TOXICOLOGY

Cyanobacterial bioactive metabolites—A review of their chemistry and biology

(2019) I-Shuo Huang et al.   HARMFUL ALGAE

First report of anatoxin-a producing cyanobacteria in Australia illustrates need to regularly up-date monitoring strategies in a shifting global distribution

(2019) Nijoy John et al.   Scientific Reports

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

(2019) Du et al.   Toxins

The wonderland of neuronal nicotinic acetylcholine receptors

(2018) Daniel Bertrand et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

(2018) Michele Zoli et al.   Current Neuropharmacology

Widespread anatoxin-a detection in benthic cyanobacterial mats throughout a river network

(2018) Keith Bouma-Gregson et al.   PLoS One

Fatal Neurotoxicosis in Dogs Associated with Tychoplanktic, Anatoxin-a Producing Tychonema sp. in Mesotrophic Lake Tegel, Berlin

(2018) Jutta Fastner et al.   Toxins

Variability in the anatoxin gene clusters of Cuspidothrix issatschenkoi from Germany, New Zealand, China and Japan

(2018) Andreas Ballot et al.   PLoS One

Anatoxins are consistently released into the water of streams with Microcoleus autumnalis-dominated (cyanobacteria) proliferations

(2018) Susanna A. Wood et al.   HARMFUL ALGAE

Spatial and Temporal Variability in the Development and Potential Toxicity of Phormidium Biofilms in the Tarn River, France

(2018) Isidora Echenique-Subiabre et al.   Toxins

The Abundance of Toxic Genotypes Is a Key Contributor to Anatoxin Variability in Phormidium-Dominated Benthic Mats

(2017) Susanna Wood et al.   Marine Drugs

Acute animal and human poisonings from cyanotoxin exposure — A review of the literature

(2016) Roslyn Wood   ENVIRONMENT INTERNATIONAL

The rise of toxic benthic Phormidium proliferations: A review of their taxonomy, distribution, toxin content and factors regulating prevalence and increased severity

(2016) Tara G. McAllister et al.   HARMFUL ALGAE

Cyanotoxin bioaccumulation in freshwater fish, Washington State, USA

(2015) F. Joan Hardy et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Co-occurrence of microcystin and anatoxin-a in the freshwater lake Aydat (France): Analytical and molecular approaches during a three-year survey

(2015) Marion Sabart et al.   HARMFUL ALGAE

Toxic Picoplanktonic Cyanobacteria—Review

(2015) Natalia Jakubowska et al.   Marine Drugs

High resolution/accurate mass (HRMS) detection of anatoxin-a in lake water using LDTD–APCI coupled to a Q-Exactive mass spectrometer

(2015) Audrey Roy-Lachapelle et al.   TALANTA

Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies

(2015) S. Shams et al.   WATER RESEARCH

Health-Based Cyanotoxin Guideline Values Allow for Cyanotoxin-Based Monitoring and Efficient Public Health Response to Cyanobacterial Blooms

(2015) David Farrer et al.   Toxins

Integrative Monitoring of Marine and Freshwater Harmful Algae in Washington State for Public Health Protection

(2015) Vera Trainer et al.   Toxins

Merging old and new perspectives on nicotinic acetylcholine receptors

(2014) Roger L. Papke   BIOCHEMICAL PHARMACOLOGY

Accumulation and effects of cyanobacterial microcystins and anatoxin-a on benthic larvae of Chironomus spp. (Diptera: Chironomidae)

(2014) Magdalena TOPOROWSKA et al.   EUROPEAN JOURNAL OF ENTOMOLOGY

Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

(2014) Annick Méjean et al.   TOXICON

Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors

(2014) Fernando Rubio et al.   TOXICON

Freshwater Harmful Algal Blooms: Toxins and Children's Health

(2014) Chelsea A. Weirich et al.   Current Problems in Pediatric and Adolescent Health Care

Impact of Environmental Factors on the Regulation of Cyanotoxin Production

(2014) Thangavelu Boopathi et al.   Toxins

Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS

(2014) Jon Sanchez et al.   Toxins

Co-occurrence of the Cyanotoxins BMAA, DABA and Anatoxin-a in Nebraska Reservoirs, Fish, and Aquatic Plants

(2014) Maitham Al-Sammak et al.   Toxins

Determination of anatoxin-a stability under certain abiotic factors

(2013) Ariel Kaminski et al.   HARMFUL ALGAE

Cyanotoxin diversity and food web bioaccumulation in a reservoir with decreasing phosphorus concentrations and perennial cyanobacterial blooms

(2013) Barbara Pawlik-Skowrońska et al.   HARMFUL ALGAE

Interpreting the Possible Ecological Role(s) of Cyanotoxins: Compounds for Competitive Advantage and/or Physiological Aide?

(2013) Aleicia Holland et al.   Marine Drugs

A review of current knowledge on toxic benthic freshwater cyanobacteria – Ecology, toxin production and risk management

(2013) Quiblier Catherine et al.   WATER RESEARCH

Phormidium autumnale Growth and Anatoxin-a Production under Iron and Copper Stress

(2013) Francine Harland et al.   Toxins

Selection and optimisation of a method for efficient metabolites extraction from microalgae

(2012) Benoît Serive et al.   BIORESOURCE TECHNOLOGY

Environmental conditions that influence toxin biosynthesis in cyanobacteria

(2012) Brett A. Neilan et al.   ENVIRONMENTAL MICROBIOLOGY

Anatoxin-a-producing Raphidiopsis mediterranea Skuja var. grandis Hill is one ecotype of non-heterocytous Cuspidothrix issatschenkoi (Usačev) Rajaniemi et al. in Japanese lakes

(2012) Yoshikuni Hodoki et al.   HARMFUL ALGAE

Diversity and distribution of cyanobacterial toxins in the Italian subalpine lacustrine district

(2012) Leonardo Cerasino et al.   OCEANOLOGICAL AND HYDROBIOLOGICAL STUDIES

Simultaneous accumulation of anatoxin-a and microcystins in three fish species indigenous to lakes affected by cyanobacterial blooms

(2012) Barbara Pawlik-Skowrońska et al.   OCEANOLOGICAL AND HYDROBIOLOGICAL STUDIES

First report of (homo)anatoxin-a and dog neurotoxicosis after ingestion of benthic cyanobacteria in The Netherlands

(2012) Elisabeth J. Faassen et al.   TOXICON

Effect of Nitrogen on Cellular Production and Release of the Neurotoxin Anatoxin-A in a Nitrogen-Fixing Cyanobacterium

(2012) Alexis Gagnon et al.   Frontiers in Microbiology

Spatial and temporal variability in Phormidium mats and associated anatoxin-a and homoanatoxin-a in two New Zealand rivers

(2011) MW Heath et al.   AQUATIC MICROBIAL ECOLOGY

The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change

(2011) J.M. O’Neil et al.   HARMFUL ALGAE

Diagnosis of Anatoxin-a Poisoning in Dogs from North America

(2011) Birgit Puschner et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Cyanotoxins: Bioaccumulation and Effects on Aquatic Animals

(2011) Aloysio da S. Ferrão-Filho et al.   Marine Drugs

Development of a fast and selective method for the sensitive determination of anatoxin-a in lake waters using liquid chromatography–tandem mass spectrometry and phenylalanine-d 5 as internal standard

(2010) Ioannis K. Dimitrakopoulos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors

(2010) Rómulo Aráoz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria sp. Strain PCC 6506: Identification of the cyr Gene Cluster and Toxin Analysis

(2010) R. Mazmouz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites

(2010) A. Mejean et al.   JOURNAL OF BACTERIOLOGY

Molecular Aspects of Microcystin-induced Hepatotoxicity and Hepatocarcinogenesis

(2010) Z. Svirčev et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Treatment and diagnosis of a dog with fulminant neurological deterioration due to anatoxin-a intoxication

(2010) Birgit Puschner et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Basic principles of neuromuscular transmission

(2009) J. A. J. Martyn et al.   ANAESTHESIA

Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a-Producing Oscillatoria Cyanobacteria

(2009) S. Cadel-Six et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolated strains of Cylindrospermopsis raciborskii from Lake Balaton (Hungary) produce anatoxin-a like neurotoxins

(2009) Ágnes Vehovszky et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Evidence that Biosynthesis of the Neurotoxic Alkaloids Anatoxin-a and Homoanatoxin-a in the CyanobacteriumOscillatoriaPCC 6506 Occurs on a Modular Polyketide Synthase Initiated byl-Proline

(2009) Annick Méjean et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurotoxic cyanobacterial toxins

(2009) Rómulo Aráoz et al.   TOXICON

Anatoxin-a degradation by Advanced Oxidation Processes: Vacuum-UV at 172 nm, photolysis using medium pressure UV and UV/H2O2

(2009) Atefeh Afzal et al.   WATER RESEARCH

Uptake and depuration of anatoxin-a by the mussel Mytilus galloprovincialis (Lamarck, 1819) under laboratory conditions

(2008) Joana Osswald et al.   CHEMOSPHERE

Pathways of Acetylcholine Synthesis, Transport and Release as Targets for Treatment of Adult-Onset Cognitive Dysfunction

(2008) F. Amenta et al.   CURRENT MEDICINAL CHEMISTRY

Effects of cyanobacterial extracts containing anatoxin-a and of pure anatoxin-a on early developmental stages of carp

(2008) J. Osswald et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Toxic effects of anatoxin-a on testes and sperm counts of male mice

(2008) Altug Yavasoglu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Effects of weekly exposure to anatoxin-a and nicotine on operant performance of rats

(2008) K.A. Jarema et al.   NEUROTOXICOLOGY AND TERATOLOGY