Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Jolanda van Keizerswaard, Alexandra L. P. Dietz de Loos, Yvonne Louwers, Joop S. E. Laven
Summary: This study assessed the effects of aging on the features of polycystic ovary syndrome (PCOS). The results showed that the prevalence of PCOS phenotype groups changed over time, with a more regular menstrual cycle, decreased serum androgen levels, and improved polycystic ovarian morphology in women with PCOS as they aged.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Leili Rahmatnezhad, Lida Moghaddam-Banaem, Tahereh Lak, Afshin Shiva, Javad Rasuli
Summary: This study aimed to determine the levels of free androgen index (FAI) and its association with oxidative stress and insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients. The prevalence of the four PCOS phenotypes in 160 participants was determined, and it was found that phenotype C had the highest FAI levels. In linear regression analysis, PCOS phenotype, follicle-stimulating hormone (FSH) levels, and malondialdehyde (MDA) levels were significantly related to FAI, while homeostatic model assessment for insulin resistance (HOMA-IR) was not associated with FAI.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Fisun Vural, Birol Vural, Eyupcan Kardas, Ayse Deniz Erturk Coskun, Irem Yildirim
Summary: This study investigated the utilization of Anti-Mullerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. The results showed that AMH can be used with high diagnostic accuracy instead of PCOM in Rotterdam criteria, especially for phenotype A and D.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Biology
Afrin Yasmin, Shubhadeep Roychoudhury, Arun Paul Choudhury, A. B. Fuzayel Ahmed, Sulagna Dutta, Filomena Mottola, Vivek Verma, Jogen C. Kalita, Dhruv Kumar, Pallav Sengupta, Adriana Kolesarova
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine reproductive system condition in women of childbearing age, characterized by hyperandrogenism and oligomenorrhea. PCOS is associated with various side effects, including type 2 diabetes, early atherosclerosis, infertility, and endometrial cancer. The prevalence of PCOS varies significantly due to factors such as diagnostic criteria, racial and ethnic differences, associated lifestyle factors, and related illnesses.
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Michal Kunicki, Anna Calik-Ksepka, Katarzyna Suchta, Anna Duszewska, Katarzyna Smolarczyk, Roman Smolarczyk
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women, characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. The role of Anti-Mullerian Hormone in PCOS still requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Marina A. Skiba, Robin J. Bell, Dilinie Herbert, Alejandra Martinez Garcia, Rakibul M. Islam, Susan R. Davis
Summary: Despite applying stringent criteria for the diagnosis of PCOS in a non-healthcare seeking community-based sample, there remains a risk of diagnostic uncertainty in identifying women with PCOS.
HUMAN REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Stefano Palomba, Carla Colombo, Andrea Busnelli, Donatella Caserta, Giovanni Vitale
Summary: This study comprehensively reviews the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction by analyzing available evidence in nine main areas of interest. The results suggest that PCOS and thyroid disorders are closely related, and their coexistence may increase the reproductive and metabolic risk of patients. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C. Edwards, Blake J. Cochran, William L. Ledger, Robert B. Gilchrist, Michael J. Bertoldo, Lindsay E. Wu, Kirsty A. Walters
Summary: PCOS is characterized by reproductive and endocrine abnormalities, with metabolic dysregulation. Recent study found that treating obese, pre-diabetic women with NMN could improve skeletal muscle insulin sensitivity. The research on DHT-induced PCOS mouse model showed that NMN treatment could normalize NAD levels in muscle, leading to the improvement of metabolic dysfunction and insulin sensitivity.
MOLECULAR METABOLISM
(2022)
Article
Psychiatry
Han Lin, Mingxing Liu, Dongmei Zhong, Ernest Hung Yu Ng, Jianping Liu, Juan Li, Yu Shi, Chunren Zhang, Xiaohui Wen, Zhefen Mai, Miaoxian Ou, Hongxia Ma
Summary: The study found that the prevalence of anxiety-like and depression-like behaviors among PCOS patients was 26.1% and 52.0%, respectively. These behaviors were associated with factors such as age, body image-related factors, hyperandrogenism-related factors, and metabolic factors. Body image-related factors and hyperandrogenism-related factors were related to both anxiety-like and depression-like behaviors in both infertile and fertile PCOS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Ana Cutillas-Tolin, Julian Jesus Arense-Gonzalo, Jaime Mendiola, Evdochia Adoamnei, Fuensanta Navarro-Lafuente, Maria Luisa Sanchez-Ferrer, Maria Teresa Prieto-Sanchez, Ana Carmona-Barnosi, Jesus Vioque, Alberto M. Torres-Cantero
Summary: This study explored the associations between adherence to five dietary quality indices and the presence of PCOS, finding an inverse association between AHEI-2010 index and a specific PCOS phenotype. However, no statistically significant associations were found between dietary indices and total anovulatory or ovulatory PCOS, highlighting the need for further research with larger sample sizes to explore these associations among the diverse phenotypes of PCOS.
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Valentina Rodriguez Paris, Xin Yi Denise Wong, Samantha M. Solon-Biet, Melissa C. Edwards, Ali Aflatounian, Robert B. Gilchrist, Stephen J. Simpson, David J. Handelsman, Nadeem O. Kaakoush, Kirsty A. Walters
Summary: The study found that diet influences gut microbiota diversity, but overall gut microbiota composition is affected by PCOS pathology. The role of the gut microbiome in the development of PCOS traits was explored, and PCOS-like mice transplanted with healthy fecal microbiota did not show improvement in PCOS traits.
Article
Obstetrics & Gynecology
Katherine VanHise, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, Jessica L. Chan
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women worldwide. There are racial and ethnic differences in PCOS phenotypes and metabolic dysfunction. This review summarizes the current literature on disparities in PCOS diagnosis and outcomes in the United States. Future studies should focus on racial and ethnic-specific differences in PCOS and include a diverse population in PCOS research.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Anju E. Joham, Nadira S. Kakoly, Helena J. Teede, Arul Earnest
Summary: This study found a significantly higher incidence of hypertension among women with PCOS compared to those without, especially among obese women. PCOS was independently associated with an increased risk of hypertension, further exacerbated by obesity. Including PCOS in hypertension risk assessments may help in early identification and management of the disorder.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
