Journal
EMBO JOURNAL
Volume 40, Issue 5, Pages -Publisher
WILEY
DOI: 10.15252/embj.2021107651
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Recent research has identified alveolar type II cells as the primary cell type infected by SARS-CoV-2 and demonstrated the effectiveness of interferon lambda 1 treatment in dampening lung infection.
Defining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.
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